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NCT ID: NCT06228820 Recruiting - Clinical trials for Platelet Dysfunction Due to Drugs

Aspirin Resistance in Trinidad.

ART
Start date: January 15, 2024
Phase: Phase 2
Study type: Interventional

Aspirin's beneficial effect is mediated via the inhibition of arachidonic acid (AA) activation of platelets. It is detected by demonstrating a decrease in platelet function and/or a decrease in prostaglandin metabolites. Besides inhibiting the formation of thromboxane A2 from arachidonic acid, Aspirin has a host of platelet-independent effects that complement its platelet-inhibitory effects. The phenomenon of "Aspirin resistance" is based on the observation of clinical events in some patients taking Aspirin and/or a diminished platelet aggregation inhibitory response to Aspirin therapy. It has been suggested that many individuals taking Aspirin have become resistant to this drug. Unfortunately, laboratory assays used to monitor the efficacy of Aspirin are far from accurate, and the results are not reproducible. Multiple studies demonstrate non-compliance using repeat testing for platelet inhibition in patients with an initial inadequate response to Aspirin. When the test is repeated under the condition that the ingestion of the test Aspirin is assured, the patients' platelets are inhibited. Patients with an inadequate Aspirin response have an increased likelihood of subsequent vascular events.

NCT ID: NCT06031077 Completed - Clinical trials for Cardiovascular Diseases

Effectiveness and Safety of Distal Left Transradial Access in Coronary Procedures.

Start date: January 1, 2020
Phase:
Study type: Observational

To evaluate the effectiveness and safety of distal left radial (dLR) access in coronary procedures at a tertiary center in Trinidad and Tobago.

NCT ID: NCT05937360 Recruiting - Clinical trials for Polycystic Ovary Syndrome

Prevalence of Polycystic Ovary Syndrome In Trinidad

Start date: January 1, 2023
Phase:
Study type: Observational

According to World Health Organization (WHO), in 2010, Polycystic Ovarian Syndrome (PCOS) affected approximately 116 million women worldwide (3.4% of the population). It has been considered one of the most common causes of female infertility and the most common endocrine disorder. The standard diagnosis for the syndrome dates back to international conferences organized by the National Institutes of Health (NIH) in 1990 and the Rotterdam European Society of Human Reproduction and Embryology/ American Society for Reproductive Medicine (ESHRE/ASRM) sponsored PCOS consensus workshop group in 2003 and 2004. Clinical manifestations of the disease may include menstrual irregularities, amenorrhea, ovulation-related infertility, polycystic ovaries, and signs of androgen excess such as acne and hirsutism. This condition may also lead to chronic diseases such as obesity, type 2 diabetes (T2D), dyslipidaemia, and cardiovascular events. Despite the increasing knowledge concerning PCOS, the global picture of the disorder is deficient in a number of geographic regions. Understanding the global prevalence will help to better assess the public health and economic implications of PCOS in Trinidad, allow for improved screening methods, help elucidate the underlying factors and foster improved understanding of the molecular mechanisms in improving the evolutionary process.

NCT ID: NCT05547022 Completed - Clinical trials for Limb Salvage Rates With Endovascular Therapy

Endovascular Limb Salvage in Trinidad and Tobago

Start date: May 1, 2018
Phase:
Study type: Observational

The purpose of this study was to investigate limb salvage rates in patients with critical limb ischemia after endovascular revascularization.

NCT ID: NCT05256550 Completed - Stroke Clinical Trials

Stroke Outcome Analysis and Registry in Trinidad and Tobago

StART
Start date: March 1, 2022
Phase:
Study type: Observational [Patient Registry]

This is a prospective observational study to assess risk factors, functional outcomes and mortality at three months for persons admitted to hospital with stroke and transient ischemic attack. Persons who were admitted with a diagnosis of stroke or transient ischemic attack at Eric Williams Medical Sciences Complex (EWMSC), Trinidad and Tobago will be screened for eligibility as participants. Demographic and clinical data will be taken from the patient records and then a follow up survey regarding functional outcome will be done at three months. Informed verbal consent will be obtained. Data will be stored in case report forms, and unique coded identifiers will be used to preserve participant anonymity. Data will also be encrypted and kept in a password protected computer in a locked cabinet. Two clinical research associates will check quality of data throughout the study and routine statistical analysis will be performed.

NCT ID: NCT04774861 Completed - Clinical trials for Coronary Artery Disease

Correlation of Cardiac Computed Tomography Angiography Dimensions and Ethnicity in Trinidad

CADET
Start date: August 1, 2020
Phase:
Study type: Observational

The aim of this study is to compare coronary artery dimensions on Cardiac CT angiography amongst different ethnicities in Trinidad.

NCT ID: NCT04554901 Completed - Clinical trials for Platelet Dysfunction

The Effect of Cocoa on Platelet Function Profiles in Patients

ECLAIR
Start date: September 1, 2020
Phase: N/A
Study type: Interventional

The effects of chocolate on cardiovascular health are still a matter of debate. It can potentially favor cardiovascular health through the antioxidative effects of cocoa ingredients, such as polyphenols (present in dark but not white chocolate).

NCT ID: NCT04400760 Completed - Clinical trials for Platelet Dysfunction

The Effect of Dapagliflozin on Platelet Function testinG Profiles in Diabetic PatiEnts.

EDGE
Start date: May 1, 2020
Phase: Phase 2/Phase 3
Study type: Interventional

Sodium GLucose Transport 2 inhibitors (SGLT2I), including dapagliflozin, reduce the likelihood of hospitalization for heart failure and death in persons with type 2 diabetes, of which the mechanism has not been fully elucidated. The mechanistic effects of dapagliflozin on platelet function profiles have not yet been ascertained. It remains unclear if this reduction in cardiovascular death is mediated by decreased platelet reactivity.

NCT ID: NCT04388540 Completed - Iodine Deficiency Clinical Trials

Caribbean Island Urinary Iodine Survey 2018

CRUISE
Start date: January 1, 2018
Phase:
Study type: Observational

Many of the Caribbean island nations have no data on iodine status in their populations. Iodine deficiency in children can reduce IQ but can be easily corrected through a program of salt iodization. The study will be located at 11 islands of the Caribbean region. At each of the 11 study sites, we will measure the iodine status in school-age children by collecting morning spot urine samples for measurement of urinary iodine concentration (UIC). We will also measure height and weight in all children. We will collect a repeat, next-day spot urine sample in 1/3rd of children to adjust for intra-individual variation in spot UIC and calculate the distribution of population intake.

NCT ID: NCT04342819 Completed - Clinical trials for Platelet Dysfunction Due to Drugs

The Effect of empagliFlozin on Platelet Function profilEs in diabetiC patienTs - The EFFECT Study.

EFFECT
Start date: January 1, 2020
Phase: Phase 2/Phase 3
Study type: Interventional

The mechanistic effects of empagliflozin on platelet function profiles have not yet been ascertained.