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NCT ID: NCT05332704 Suspended - Plaque Psoriasis Clinical Trials

Safety, Tolerability, PK, PD and Preliminary Efficacy of ONO-4685

Start date: March 25, 2022
Phase: Phase 1
Study type: Interventional

This is an early phase study to assess the safety and tolerability of ONO-4685 in patients with psoriasis. In addition, the study will assess how the drug is distributed and eliminated by the body (pharmacokinetics) and how the drug affects the body (pharmacodynamics). This will be done by measuring the amount of drug in the blood and measuring other markers in the body that might have been affected by ONO-4685. The study will also look at preliminary information on whether ONO-4685 might be effective in treating psoriasis. The study will be split into three parts. Part A will assess a single dose of ONO-4685 in small groups of patients, each group planned to receive a higher dose than the last group. In Part B and C, patients will receive multiple doses of ONO-4685 over a period of 4 weeks.

NCT ID: NCT05126576 Suspended - COVID-19 Clinical Trials

Study to Evaluate the Effects of RO7496998 (AT-527) in Non-Hospitalized Adult and Adolescent Participants With Mild or Moderate COVID-19

MORNINGSKY
Start date: April 28, 2021
Phase: Phase 3
Study type: Interventional

This study will evaluate the efficacy, safety, antiviral activity, and pharmacokinetics of study drug RO7496998 (AT-527) compared to placebo in non-hospitalized adult and adolescent participants with mild to moderate coronavirus disease 2019 (COVID-19) in the outpatient setting.

NCT ID: NCT04436770 Suspended - Stroke Sequelae Clinical Trials

Medical Recovery and Social Reintegration for Post-stroke Patients Using Virtual Reality

Start date: July 18, 2019
Phase: N/A
Study type: Interventional

Application of Virtual Reality therapy and occupational therapy versus and standard physiotherapy and occupational therapy to patients with post-stroke sequelae, using specifical assessment tools, standard physiotherapy and occupational therapy programs.

NCT ID: NCT02326077 Suspended - Clinical trials for Obstetric Labor Complications

Sonopartogram. The Next Step in the Delivery Room

SONOLABOR
Start date: October 1, 2020
Phase:
Study type: Observational

Objectives: - Evaluation of the correlation between the sonographic parameter and clinical findings (e.g. digital examination) in any cephalic (not only occipital anterior) position - Examination of the relationship between various sonographic parameters - Determination of intraobserver and interobserver variation in obtaining the sonographic measurements - Analysis of the temporal variation of the different sonographic measurements in normal spontaneous vaginal delivery versus obstructed labor in fetuses with occiput anterior versus those with persistent occiput posterior - Establishment of a sonopartogram that should replace in an objective way Friedmann - Establishment of cut-off values that may help clinicians to choose between vaginal operative delivery or caesarean section - Another interesting aspect of intrapartum transperineal ultrasound imaging is whether there is a psychological benefit to the patient in being able to follow on the ultrasound screen how fetal head descent and position are being assessed objectively.