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NCT ID: NCT05045885 Completed - Respiratory Failure Clinical Trials

Safety and Feasibility of Percutaneous Dilatational Tracheostomy in Patients With Severe COVID-19 Supported by ECMO

Start date: March 1, 2020
Phase:
Study type: Observational [Patient Registry]

COVID-19 pandemic has presented the global health care systems with unprecedented and unexpected challenges. The clinical spectrum of COVID-19 disease varies from mild, at times asymptomatic, to severe life-threatening multiple organ dysfunction and shock. The latter group, albeit represent less than 10% of all SARS-CoV-2 infections will require ICU admission, multi-modal organ support including Extracorporeal Membrane Oxygenation (ECMO) for severe refractory cardiac and/or pulmonary failure. Prolonged mechanical ventilation is a typical indication for tracheostomy. Percutaneous tracheostomy at the bedside has several advantages over surgical tracheostomy. However, with the emerging pandemic, there is a lack of literature regarding the safety of percutaneous bedside tracheostomy for patients with COVID-19 supported by ECMO. Our study aims to describe the safety of bedside percutaneous dilatational tracheostomy of confirmed COVID-19 positive patients supported on ECMO.

NCT ID: NCT05043779 Recruiting - Obesity, Morbid Clinical Trials

Evaluation of Preoperative Nasoendoscopy to Predict Difficult Intubation

Start date: August 12, 2020
Phase: N/A
Study type: Interventional

Despite the availability of different methods for airway assessment, unexpectedly difficult intubations occur at a frequency of up to 15%. A variety of pre-intubation clinical screening tests have been advocated to predict difficult laryngoscopy and airway but their usefulness is limited in obese patients. Could awake invasive airway assessment be more predictive for difficult airways in obese patients? The use of nasendoscopy assessment for the airway could be a useful additional invasive tool to predict the difficult airway in obese

NCT ID: NCT05033730 Recruiting - Clinical trials for Ventilation Therapy; Complications

Comparison Between VCV and FCV Through Ultra-thin Tube in Upper Airway Surgery

Start date: October 15, 2020
Phase: N/A
Study type: Interventional

Ventilation through the small endotracheal tube is not an uncommon situation. The indications for it differ from elective upper airway surgery to emergency ventilation through needle cricothyrotomy. Conventionally, ventilation through small endotracheal tubes has been challenging by jet ventilation with subsequent risk of barotrauma and inadequate gas exchange. Expiration during jet ventilation occurs passively.

NCT ID: NCT05033704 Recruiting - Clinical trials for Coagulation; Intravascular

Effect of Human Plasma Protein Transfusion With and Without Crystalloids During Major Liver Resection Surgeries

Start date: September 9, 2019
Phase: N/A
Study type: Interventional

Evaluation of acid-base and electrolyte changes after administration of commonly used colloid solutions (plasma protein fraction contains 5% albumin), and crystalloids (saline 0.9% and lactated ringers solutions) is the primary endpoint of this study. The secondary endpoints are to study dilution acidosis and changes in plasma volume induced by albumin versus crystalloids and their effect on tissue perfusion by randomizing patients into two groups where each group receives intraoperatively one type of the two fluids. Changes in acid-base, electrolytes, and dilution acidosis

NCT ID: NCT05021523 Completed - Clinical trials for Immobilization, Tonic

Heat Therapy to Prevent Deconditioning During Immobilization

Start date: November 26, 2020
Phase: N/A
Study type: Interventional

Animal models suggest that heat stress increases protein content and facilitates the recovery of atrophied muscle after an immobilization period, or following a chemically induced muscle injury in rats. Thus, a recent study in human have reported that daily heat treatments, applied during 10 days of immobilization, reduced the loss of muscle mass. In addition of protecting muscle mass, repeated heat stress may also help to maintain cardiovascular fitness from the onset of injury through passive exposures in the condition that they sufficiently trigger an increase in body temperature, circulation and sweating. This study will investigate the benefits of using heat therapy to prevent deconditioning during immobilization in human.

NCT ID: NCT04992221 Recruiting - Arterial Monitoring Clinical Trials

Arterial Line Patency in ICU Bound COVID-19 Patients

Start date: February 1, 2021
Phase:
Study type: Observational

Severe acute respiratory syndrome coronavirus-2 (SARS-Cov-2) overwhelmed the health care system and ICU admission was maximized with increased work load of ICU physicians. Invasive line procedures are inserted with a dedicated team to ensure safe and perfect performance. Frequent requests for arterial line insertion were observed during the second wave follow up of COVID-19 bound patients. High rates of thrombosis were found in those critically ill patients which was associated with thrombotic complications. Many factors are contributed for reduction of arterial line patency, including morbidities of patients, technique of insertion, and criteria of the operating health care skilled personnel. In response of our ICU management committee to increase incidence of thrombosis and pulmonary embolic events in patients with COVID-19 admitted to ICU in the second wave of the epidemic, they recommended the use of systemic anti coagulation of ICU admitted patients since 21 March 2021.

NCT ID: NCT04991545 Recruiting - Covid19 Clinical Trials

Feasibility of the Infra-Red Illumination for Facilitation of Video Scope-tracheal Intubation

Start date: January 13, 2021
Phase: N/A
Study type: Interventional

Airway securing through the placement of an endotracheal tube continues to be the definitive and the global standard management. The successful first attempt is aimed to avoid the consequences of multiple intubation trials as bleeding, tissue swelling, and airway contamination from gastric content that led to considerable morbidity and mortality. Visualization of the larynx and the glottic opening is the key to first-pass success requiring long-term training and availability of specific equipment concerned to that. For confirmation of the position endotracheal tube or its displacement, various clinical and equipment aids to that which are not valid or limited in different scenarios. Video laryngoscopes (VL) have been proposed to improve laryngeal visualization, hence a higher first-pass success rate accomplished. Despite that, there are limitations of video laryngoscope use in different circumstances that requiring adding of other aids to facilitate endotracheal intubation. x

NCT ID: NCT04989023 Not yet recruiting - Clinical trials for Patellofemoral Pain Syndrome

Clinical Applications of Blood Flow Restriction and Rehabilitation Outcomes

Start date: August 2021
Phase: N/A
Study type: Interventional

The study aims to evaluate the effect of low load resistance training combined with blood flow restriction or sham blood flow restriction in patients with anterior knee pain and rotator cuff related shoulder pain in a cross-over two-arm randomized, participant and assessor blinded design. More specifically, we aim to investigate the acute and short-term hypoalgesic response (by evaluating pressure pain detection thresholds) of low load exercise with blood flow restriction or sham blood flow restriction, the effect of these interventions in pain during clinical testing, and the possibility of a placebo effect.

NCT ID: NCT04917627 Recruiting - Wound Infection Clinical Trials

To Assess Use of Vancomycin Powder in Craniotomy on Wound Infection Rates

Start date: May 1, 2021
Phase: Phase 4
Study type: Interventional

Surgical site infection (SSI) after craniotomy is a major cause of morbidity and mortality besides its major health care cost. In each hospital, all measures are taken to decrease SSI. Despite current prophylactic measures, rates of SSIs have been reported in up to 5% of patients post craniotomy. Intrawound vancomycin powder has been studied extensively in spinal fusion surgeries and been found to reduce rates of surgical site infections (SSIs) significantly. Despite its success in spinal surgeries, topical vancomycin has not been extensively studied with respect to cranial neurosurgery. The use of adjuvant vancomycin powder was associated with a significant reduction in the incidence of postoperative infection as well as infection-related medical costs. These findings suggest that the use of adjuvant vancomycin powder in high-risk patients undergoing spinal fusion is a cost-saving option for preventing postoperative infections, as it can lead to cost-savings of $438,165 per 100 spinal fusions performed. The investigators believe that Topical vancomycin is a safe, effective, and cost-saving measure to prevent SSIs following craniotomy.

NCT ID: NCT04916509 Not yet recruiting - Breast Neoplasms Clinical Trials

Treatment Patterns and Clinical Outcomes Among Patients Receiving Palbociclib Combinations for Hormone Receptor Positive (HR+)/Human Epidermal Growth Factor Receptor 2 Negative (HER2 ) Advanced/Metastatic Breast Cancer in the Arabian Gulf Region

Start date: May 31, 2021
Phase:
Study type: Observational

retrospective non-interventional study (NIS) that aims to describe the demographics, clinical characteristics, clinical outcomes, and treatment patterns, among patients receiving palbociclib for the treatment of HR+/HER2- metastatic/locally advanced breast cancer (BC)