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NCT ID: NCT04802616 Completed - Clinical trials for Allergic Rhinitis Due to Grass Pollen

The Influence of Nonspecific Immunostimulation on Changes in the Concentration of iNKT Cells

Start date: March 22, 2021
Phase: Phase 3
Study type: Interventional

The aim of the study is to assess the effect of polyvalent mechanical bacterial lysate (PMBL, Ismigen) on the clinical course of grass pollen-induced allergic rhinitis (using: total nasal symptom score, visual analogue scale, peak nasal inspiratory flow measurement) in children aged 5 to 17 and to assess changes in the concentration of iNKT cells under the influence of the therapy. Half of the 80 participants will receive PMBL while the other half will receive placebo.

NCT ID: NCT04802369 Completed - Heart Failure Clinical Trials

Factors and Prognostic Significance of Impaired Exercise Tolerance in Women Over 40 With Arterial Hypertension

Start date: February 1, 2019
Phase: N/A
Study type: Interventional

The subject of the study is evaluation of factors affecting to exercise intolerance in spiroergometry in women over 40 years of age with hypertension and association and relationship between the parameters of physical performance and prognosis in this group of patients.

NCT ID: NCT04800315 Completed - Dermatitis, Atopic Clinical Trials

A Study to Evaluate Safety and Effectiveness of Cendakimab (CC-93538) in Participants With Moderate to Severe Atopic Dermatitis

Start date: May 14, 2021
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the effectiveness and safety of 3 dose regimen of CC-93538 in adult participants with moderate to severe Atopic Dermatitis (AD).

NCT ID: NCT04797650 Completed - Alopecia Areata Clinical Trials

Study to Evaluate the Efficacy and Safety of CTP-543 in Adults With Moderate to Severe Alopecia Areata (THRIVE-AA2)

THRIVE-AA2
Start date: June 10, 2021
Phase: Phase 3
Study type: Interventional

This study evaluates the safety and effectiveness of an investigational study drug (called CTP-543) in adults (18 years and older) who have 50% or greater scalp hair loss.

NCT ID: NCT04793451 Completed - Obesity Clinical Trials

Endurance-strength Training in Obese Women

PSYCHENDOFIT
Start date: December 6, 2012
Phase: N/A
Study type: Interventional

The aim of this study was to compare the effects of three months' endurance training and three months' endurance-strength training on selected psychological aspects in women with abdominal obesity.

NCT ID: NCT04792385 Completed - Safety Clinical Trials

Safety, Compliance and Pharmacokinetics of Estetrol Monohydrate/Drospirenone 15/3 mg in Post-menarchal Female Adolescents

Start date: December 28, 2020
Phase: Phase 3
Study type: Interventional

To evaluate the safety, compliance, and pharmacokinetics profile of estetrol monohydrate (E4) 15 mg combined with drospirenone (DRSP) 3 mg in post-menarchal participants between the age of 12 and 17 years + 2 months.

NCT ID: NCT04791553 Completed - Hepatic Impairment Clinical Trials

Safety Study of Cenobamate in Subjects With Normal Hepatic Function and Subjects With Severe Hepatic Impairment

Start date: June 17, 2021
Phase: Phase 1
Study type: Interventional

This study is designed investigate the effect of severe hepatic impairment on the pharmacokinetics (PK) of cenobamate.

NCT ID: NCT04791007 Completed - HIV Prevention Clinical Trials

OB-002H Gel Administered Vaginally and Rectally in HIV-1 Seronegative Adults

Start date: October 5, 2019
Phase: Early Phase 1
Study type: Interventional

This is a monocentric phase I study in open-label and randomized, double-blind, placebo-controlled cohorts of HIV-1 seronegative adults to evaluate the safety, acceptability, and pharmacokinetic of OB-002H Gel administrated vaginally and rectally.

NCT ID: NCT04790097 Completed - Clinical trials for Glioblastoma Multiforme

FET-PET Directed Simultaneous In-field Boost for Primary GBM

dualFETboost
Start date: February 21, 2017
Phase: N/A
Study type: Interventional

The combination of anatomical MRI examination with functional examination of tissue metabolic activity such as FET-PET (PET using the radiotracer - 18F-fluoro-ethyl-tyrosine) is a valuable tool to determine the actual tumor infiltration. The FET-PET examination can be performed using the dual-time point aqusition of FET for exact treatment planning. It has also been proven that using the dual FET-PET method, it is possible to obtain a precise image of the glioblastoma infiltration corresponding to the location and shape of the recurrence, and the tumor volumes in dual FET-PET are significantly larger than in MRI. Moreover, tumor defined in dual FET-PET is different than that of the tumor defined in single FET-PET acquisition. In the DualFETboosT trial we plan to assess the safety and preliminary efficacy of hypofractionated irraditon using simultaneous in-field boost directed on dual FET-PET based tumor volumes for treatment of primary glioblastoma multiforme with concomitant temozolomide.

NCT ID: NCT04789122 Completed - Clinical trials for End Stage Renal Disease

Assessment of Poles' Attitudes Towards Living Kidney Donation

Start date: December 10, 2020
Phase:
Study type: Observational

The main goal of the project is to examine the public opinion on living kidney donation and to assess the knowledge of Poles in this field.