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NCT ID: NCT06374875 Not yet recruiting - Obesity Clinical Trials

Fibrosis Lessens After Metabolic Surgery

FLAMES
Start date: May 1, 2024
Phase: N/A
Study type: Interventional

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), a major global public health concern, is commonly associated with obesity, diabetes, and dyslipidemia. MASLD is currently the most common cause of chronic liver disease affecting about 80% of people with obesity, ranging from simple fat deposits in the liver to Metabolic Dysfunction-Associated Steatohepatitis (MASH), cellular injury, advanced fibrosis, cirrhosis, or hepatocellular carcinoma. Patients with MASH are also at risk for cardiovascular disease and mortality. There is no universally approved medication for MASH. Weight loss remains the cornerstone of MASH treatment. Patients meeting the inclusion and exclusion criteria and who give informed consent will be enrolled in the trial and undergo the baseline liver biopsy (if none available). Approximately 120 patients with MASH and liver fibrosis (F1-F4 in baseline liver biopsy) will be randomized in a 1:1 ratio to metabolic surgery or medical treatment (incretin-based therapies ± other medical therapies for MASH) and followed for 2 years at which time a repeat liver biopsy will be performed for the assessment of the primary end point.

NCT ID: NCT05758012 Not yet recruiting - Cesarean Delivery Clinical Trials

Carbetocin Compared To Oxytocin During Cesarean Delivery

Start date: May 1, 2023
Phase:
Study type: Observational

As both oxytocin and carbetocin are used daily in obstetric units all over the world, the investigators find it compelling to investigate whether the hemodynamic and myocardial effects of oxytocin and carbetocin are comparable in healthy women during delivery and determine any potential harmful effects following the use of oxytocin or Carbetocin as uterotonic. Other endpoints relating to uterus tone, blood loss, blood pressure, heart rate, post-operative pain and side effects will also be assessed.

NCT ID: NCT05675098 Not yet recruiting - Cerebral Palsy Clinical Trials

Central Nervous System Stimulants and Physical Function in Children With Cerebral Palsy

CP
Start date: May 1, 2023
Phase: Early Phase 1
Study type: Interventional

The purpose of this study is to determine the effects of Central Nervous System Stimulants, represented by Methylphenidate and Modafinil, compared to placebo control on motor performance in children with Cerebral Palsy. This study will be a triple-masked study per the American Academy of Neurology guidelines for clinical trials.

NCT ID: NCT04617119 Not yet recruiting - Covid19 Clinical Trials

The Effects of Multi-modality Physiotherapy in Delaying or Preventing COVID-19 Patient From Admitting to ICU

Start date: November 1, 2020
Phase: N/A
Study type: Interventional

This study aims to evaluate the effectiveness of respiratory muscle training with COVID-19 patient, who has underlying health conditions, in order to delay or prevent them from admitting to ICU.

NCT ID: NCT04451239 Not yet recruiting - Keratonjunctivitis Clinical Trials

Topical Steroids and Cyclosporin-A for COVID-19 Keratoconjunctivitis

Start date: June 30, 2020
Phase: N/A
Study type: Interventional

To explore the feasibility of combined topical corticosteroid and topical cyclosporine-A in COVID-19 patients with acute keratoconjunctivitis.

NCT ID: NCT03665025 Not yet recruiting - Clinical trials for Implant Site Reaction

Immediate Implant Placement With Immediate Professionalization in Aesthetic Area

Start date: January 1, 2019
Phase: N/A
Study type: Interventional

Immediate implant placement with immediate professionalization in the maxillary esthetic zone using mixture of allograft and xenograft vs xenografts to augment the jumping gap