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NCT ID: NCT05675280 Completed - Clinical trials for Celiac Disease in Children

Iron Deficiency and TTG Normalization

Start date: February 20, 2020
Phase:
Study type: Observational

The investigators conducted a retrospective, observational cohort study which enrolled CD subjects aged 2-18y, diagnosed between Jan 2016 and Dec 2020. Demographic and laboratory data were collected at diagnosis and 1y after adherence to GFD. ID was determined according to hemoglobin and ferritin levels. The investigators compared CD subjects with and without ID at CD diagnosis in relation to TTG normalization at 1y.

NCT ID: NCT05660044 Completed - Cardiac Disease Clinical Trials

Human Factors Study of Ultrasound Navigation Software for Cardiac Imaging

Start date: July 20, 2022
Phase:
Study type: Observational

The Product is a machine learning software, that utilizes AI to provide real-time guidance to acquire diagnostic-quality ultrasound views of the heart.

NCT ID: NCT05657340 Completed - Sea Sickness Clinical Trials

Video Head Impulse Test and Seasickness Susceptibility

Start date: January 1, 2019
Phase: N/A
Study type: Interventional

This a case control study on seasickness susceptibility. 86 healthy maritime personal were divided to seasickness susceptible and non susceptible groups based on a seasickness questionnaire (Golding) and motion sickness score. All subjects from both groups underwent video head impulse testing (vHIT). VHIT parameters - gain, asymmetry ect were compared between both groups.

NCT ID: NCT05647863 Completed - Clinical trials for Substance Use Disorders

F-CaST for Individuals With Substance Use Disorder

F-CaST
Start date: November 25, 2022
Phase: N/A
Study type: Interventional

Examining the effectiveness of the F-CaST based on a controlled randomized trial in patients with SUD residing in a therapeutic community.

NCT ID: NCT05640258 Completed - Seasickness Clinical Trials

Seasickness Susceptability and Vestibular Time Constant

Start date: September 18, 2017
Phase: N/A
Study type: Interventional

Participants were selected from the military navy crewmembers prior to commencing of active sailing. A vestibular time constant was calculated based on velocity step testing on a rotatory chair at baseline, 3 months and 6 month following active sailing duty. A seasickness questionnaire (WIKER) was completed during follow-up visits. study participants were divided to three groups based on WIKER score - susceptible , non-susceptible and habituating. Vestibular time constant was compared between study groups.

NCT ID: NCT05631977 Completed - Diagnosis Clinical Trials

Prospective Acquisition of Cardiac Ultrasound Images at the Point of Care

POCUS_ACQ
Start date: January 23, 2023
Phase:
Study type: Observational

The present study is a preparatory step towards a multi-reader multi case (MRMC) randomized fully crossed study. As POCUS images are frequently not stored and not methodically acquired using a standardized image acquisition protocol this study will collect cardiac POCUS images in a prespecified manner.

NCT ID: NCT05616429 Completed - Clinical trials for IBS - Irritable Bowel Syndrome

Alcat Based Elimination Diet for the Treatment of Irritable Bowel Syndrome; a Randomized Double Blind Sham Control Trial

Start date: August 1, 2020
Phase: N/A
Study type: Interventional

Irritable bowel syndrome (IBS) is the most common GI condition with global prevalence ranging between 10-20%. Although the exact cause is not known there are increasing insights concerning the possible multifactorial etiology including low grade inflammation, neuromodulation, dysbiosis, impaired integrity of the intestinal barrier and more. Currently, it is believed that changes in the microbiota may activate mucosal innate immune responses, resulting in increased epithelial permeability, activated nociceptive sensory pathways, and dysregulation of the enteric nervous system. Nearly two thirds of patients with IBS perceive their GI symptoms to be food related, hence, food intolerance may be important factor in the pathogenesis. Diet is a part of IBS treatment but adherence, on the one hand, and restriction, on the other, remain a major problem. [Chey WD, Am J Gastroenterol,2016]. Confocal laser endomicroscopy (CLE) is a technique that permits real-time detection and quantification of changes in intestinal tissues and cells, including increases in intraepithelial lymphocytes and fluid extravasation through epithelial leaks. Based on CLE analysis of IBS patients with a suspected food intolerance, exposure to candidate food antigens caused immediate breaks, increased intervillous spaces, and increased IELs in the intestinal mucosa. These changes are associated with patient responses to exclusion diets. [Fritscher-Ravens A et al, Gastroenterology. 2019, Gastroenterology. 2014] This technic, also efficient according to former studies, is costly and invasive. The Alcat Test is a lab based immune stimulation test in which a patient's WBC's (white blood cell) are challenged with various substances including foods, additives, colorings, chemicals, medicinal herbs, functional foods, molds and pharmaceutical compounds. The Alcat Test objectively classifies a patient's response to each test substance as reactive, borderline or non-reactive. Based on these classifications, a customized elimination/rotation diet may be designed.

NCT ID: NCT05614895 Completed - Clinical trials for Bacterial Infections

A Study to Investigate the Pharmacokinetics of RO7223280 in Critically Ill Participants With Bacterial Infections

Start date: December 3, 2022
Phase: Phase 1
Study type: Interventional

The main aim of the study is to investigate the plasma pharmacokinetics (PK) and safety of intravenous (IV) administration of a single dose of 400 milligrams (mg) or 600 mg RO7223280 in critically ill participants with bacterial infections.

NCT ID: NCT05614622 Completed - Clinical trials for Posterior Synechiae of Iris

Mydriatic Drops After Combined Surgery

Start date: November 10, 2020
Phase: N/A
Study type: Interventional

The study goal is to evaluate the influence of mydriatic drops on the development of posterior synechia after combined cataract and vitrectomy surgery.

NCT ID: NCT05610371 Completed - Anesthesia, Local Clinical Trials

Intrauterine Anesthesia in Operative, Awake, Office Hysteroscopy. A Randomized Double-blind Placebo-controlled Trial

Start date: August 1, 2019
Phase: N/A
Study type: Interventional

Objective: to evaluate intrauterine lidocaine infusion effectiveness in reducing pain associated with operative, awake office hysteroscopy Methods: A total of 100 patients will be randomized for this study The control group underwent hysteroscopy using a saline distension medium. The study group underwent hysteroscopy using 10ml of 2% lidocaine that was added to the first liter of distension medium. Patients quantified their pain using a 0-10 VAS score, at the following five predefined points: baseline, before the procedure; while inserting the hysteroscope through the cervix; during the operative procedure; immediately after the procedure and 15 minutes following the procedure.