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NCT ID: NCT05202600 Not yet recruiting - Appendix Tumor Clinical Trials

Justification of Incidental Appendectomy With Respect to Pathohistological Findings

Start date: February 1, 2022
Study type: Observational

This study seeks to justify performing an incidental appendectomy according to the following hypotheses: 1. The frequency of neoplasms in pathohistological (PHD) findings of incidental appendectomy (IA) is significantly higher than in PHD findings in appendectomies for acute appendcitis (AA) 2. The number needed to treat (NNT) for appendiceal tumors in the elderly is less than 500. 3. The rate of complicated AA in the elderly population is significantly higher than in the younger age group 4. NNT IA for complicated appendicitis in the elderly is less than 300. 5. NNT IA for potential death due to AA in the elderly is less than 500.

NCT ID: NCT05202483 Completed - Clinical trials for Appendicitis in Pregnancy

A Novel Appendicitis TriMOdal Prediction Score (ATMOS) for Acute Appendicitis in Pregnancy: a Retrospective Observational Study

Start date: November 1, 2021
Study type: Observational

Acute appendicitis (AA) is a disease of younger age, but it occurs in 1 out of 500-2000 pregnancies. The current treatment of choice for AA in pregnancy is surgical. Even with standard clinical examination, serum inflammatory markers, and transabdominal ultrasound, the decision on surgical treatment of acute appendicitis (AA) and the rate of negative appendectomy in pregnancy are still unsatisfactory. There are several scoring systems (Alvarado, Tzanakis) that help making decision on operating more easier, however their specificity is either high with low sensitivity, or the other way around. In addition, all scores are based on adult non-pregnant population. We are making an observational study to develop a scoring system that would include ultrasonic imaging with clinical-biochemical parameters while not compromising sensitivity and specificity.

NCT ID: NCT05197049 Recruiting - Crohn Disease Clinical Trials

A Study of Guselkumab Subcutaneous Therapy in Participants With Moderately to Severely Active Crohn's Disease

Start date: January 17, 2022
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of guselkumab in participants with Crohn's disease.

NCT ID: NCT05181696 Recruiting - Sepsis Clinical Trials

Retrospective Analysis of Chest X-ray Severity Scoring System of COVID-19 Pneumonia

Start date: January 1, 2020
Study type: Observational

The research will be retrospective, and will include all patients who were admitted during 2020 and 2021 in the COVID-19 ICU of University Hospital Center Osijek due to pneumonia caused by the SARS CoV 2 virus. The association of chest x-ray infiltrate evolution with changes in laboratory inflammatory parameters and respiratory function parameters will be examined.

NCT ID: NCT05151094 Recruiting - Covid19 Clinical Trials

Registry of Hospitalized Patients in University Hospital Dubrava Respiratory Center

Start date: April 1, 2021
Study type: Observational [Patient Registry]

Aim of this project is to understand clinical features, clinical outcomes and efficacy and safety profiles of different therapies by analyzing a cohort of COVID-19 patients hospitalized and treated in a tertiary-level institution, University hospital Dubrava. Patients' clinical and laboratory characteristics, drug exposure and outcomes are obtained by analysis of written and electronical medical records.

NCT ID: NCT05124314 Recruiting - Abortion, Missed Clinical Trials

Comparison of Two Different Drug Regimens for Medical Treatment of Early Pregnancy Loss

Start date: October 27, 2021
Phase: Phase 4
Study type: Interventional

The purpose of this study is to compare the safety and efficacy of a combination of two drugs (mifepristone and misoprostol) to only one of these drugs (misoprostol) in medical management of missed miscarriage up to 13+6 weeks of pregnancy (early pregnancy loss). The investigators aim to enroll 220 patients within two years which would be enough to determine the difference between these two treatments with confidence.

NCT ID: NCT05121220 Recruiting - Orthodontic Relapse Clinical Trials

Changes in Dentition and Hygiene in the Retention Phase of Orthodontic Treatment

Start date: November 15, 2020
Phase: N/A
Study type: Interventional

Objective is to assess changes of dentition and periodontium, and hygiene in retention after the end of the active phase of orthodontic treatment, and relationship with gender, type of retention appliance, pre-therapeutic condition of dentition and duration of active phase of treatment.

NCT ID: NCT05109013 Recruiting - Clinical trials for Essential Hypertension

Juvenile Essential Arterial Hypertension and Vascular Function

Start date: September 1, 2021
Study type: Observational

The main goal of this study is to investigate the association of the juvenile essential arterial hypertension with systemic micro- and macrovascular reactivity and cerebral vascular function, and to examine the potential impact of elevated oxidative stress on this associations.

NCT ID: NCT05095987 Recruiting - Appendicitis Acute Clinical Trials

Evaluation and Comparison of One Day Discharge Versus Discharge Home 24 Hours After the Laparoscopic Appendectomy for Uncomplicated Appendicitis in Children

Start date: October 2, 2021
Phase: N/A
Study type: Interventional

The aim of this study was to evaluate the value and safety of discharge of a child to home care within 24 hours after laparoscopic appendectomy for uncomplicated appendicitis to reduce the impact on the child's psyche and need for hospitalisation. This was compared to the previous treatment modality of hospital stay for 2 to 4 days. To conduct this research, parents are given a two-page questionnaire that is completed in three cycles (immediately after discharge, daily until the first control and immediately before the first control). All data will be statistically processed.

NCT ID: NCT05090475 Recruiting - Clinical trials for Bacterial Infections

The Implementation of Educational Interventions on the Prescribing of Antimicrobial Drugs in Primary Health Care

Start date: January 1, 2022
Phase: N/A
Study type: Interventional

World increase in mortality from consequences of antimicrobial resistance (AMR) represents a significant public health problem. Irrational prescribing of antimicrobial drugs (AMD) in general population is one of the main causes of development AMR. This is also contributed by fact that up to 90% of total antimicrobial consumption in Europe is related to the general population. Problem of AMR has been recognized by World Health Organization and Council of European Union, which support the establishment of the antimicrobial stewardship team (A-team). A-team provides co-ordinated interventions that promote rational use of AMD. To date, no study has been carried out in which Ateam from hospital environment goes to primary health care for the purpose of rationalization prescribing of AMD by primary health care practitioners. Project for implementation of hospital A-team in primary health care in Koprivnica-KriĹževci County will be initiated using educational outreach method aimed at rationalization of the consumption of AMD.