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NCT ID: NCT06314100 Completed - Dental Caries Clinical Trials

The Effect of Aerosol Formed From Tobacco Heating Systems on the Microbiome of Supragingival Dental Biofilm

Start date: October 1, 2021
Phase:
Study type: Observational

Dental caries is a multifactorial disease primarily caused by supragingival dental biofilm. Its progression is influenced by many environmental factors, which include smoking. Tobacco heating systems (THS) are a novel tobacco product whose effect on the microbiome of the supragingival dental biofilm has not yet been investigated. The aim of the proposed research is to determine and compare the composition of the microbiomes of the supragingival dental biofilm of THS smokers, cigarette smokers, and nonsmokers using the Next Generation Sequencing method and to assess and compare the risk of new caries lesion formation between the test groups using the Cariogram method. The results of this research will provide insight into changes in the microbiome of the supragingival dental biofilm resulting from exposure to aerosols from tobacco combustion and tobacco heating.

NCT ID: NCT06087146 Completed - Clinical trials for Gastrointestinal Microbiome

Modulation of the Gut Microbiota of Professional Athletes With Sauerkraut Supplementation

KOMS
Start date: October 31, 2023
Phase: N/A
Study type: Interventional

Literature on the topic of athlete gut microbiota is scarce, and even more on the topic of its modulation. To address these issues a prospective cohort study was conceived. The cohort included young, male generally healthy professional athletes. The cohort will first be exposed to a course of sauerkraut supplementation as a synbiotic. Then the cohort will be observed without any intention for gut microbiota modulation. Before and after each study phase a gut microbiota analysis will be performed for its parameters. The aim of this study is to assess whether the intervention leads to significant changes in the gut microbiota parameters in all subjects and if yes what the signal of the intervention was, meaning whether the changes were consistent among all subjects regarding the analyzed parameter and its direction of effect. The results will be compared with data from earlier research on gut microbiota modulation in professional athletes with soluble fiber as prebiotics and a placebo. The study will provide valuable data on the athlete gut microbiota and its potential modulation.

NCT ID: NCT06020092 Completed - Clinical trials for Alveolar Ridge Enlargement

Histological Analysis of Osteogenic Potential of Biphasic Calcium Phosphate

Start date: July 31, 2021
Phase: Phase 4
Study type: Interventional

Bone healing after tooth extraction may be affected by defects in the buccal wall of the alveolus, such as fenestrations and dehiscences. Therefore, it is advisable to perform a surgical procedure such as guided bone regeneration after tooth extractions. Different biomaterials are used for this purpose. The aim of this study is to investigate the qualitative and quantitative histological changes in human biopsies taken after 6 months of healing of extraction sockets with buccal wall defects. For this purpose, the defects of 36 patients (18 per group) will be augmented with injectable biphasic calcium phosphate (I-BCP) or bovine xenograft (BX) after extraction. After six months of healing, bone biopsies will be taken and processed to the qualitative and quantitative histological analysis.

NCT ID: NCT05808855 Completed - Clinical trials for Carpal Tunnel Syndrome Bilateral

Neurological Outcomes Following Carpal Tunnel Wound-closure Techniques

Start date: May 1, 2023
Phase: N/A
Study type: Interventional

single-centre randomised prospective trial will conducted at the University Hospital of Split in Croatia. The investigators plan to enrol 100 patients, randomly assigned to suture-based wound closure (n=50) or tissue adhesive-based wound closure (n=50) with two-component skin adhesive Glubran Tiss 2®. The neurological outcomes will assessed postoperatively during the follow-up period at intervals of 2, 6, and 12 weeks respectively.

NCT ID: NCT05806489 Completed - Clinical trials for Intermittent Fasting

Glycemic Variability in Intermittent Fasting

GLUInterm
Start date: January 26, 2021
Phase: N/A
Study type: Interventional

The aim was to test the difference in glycemic variability after meal consumption during intermittent fasting and the usual diet.

NCT ID: NCT05798182 Completed - Clinical trials for Endothelial Dysfunction

Ultrasound Markers of Systemic Inflammation

Start date: December 1, 2020
Phase:
Study type: Observational

The aim of this study was to measure whether the flow rate through the brachial artery and inflammatory markers were associated with the development of tissue edema in the surgical intensive care unit patients.

NCT ID: NCT05771415 Completed - Placenta Diseases Clinical Trials

Near-infrared Spectroscopy: Differences in Placental Oxygenation in Relation to Ultrasound Maturation Grade in physiologIcal Term Pregnancies

Start date: October 1, 2019
Phase:
Study type: Observational

The aim was to compare placental oxygenation in low risk, uncompli-cated, term pregnancies measured by near-infrared spectroscopy (NIRS) in relation to the placental maturity grade determined by ultrasound assessment according to Grannum scale. The study included 34 singleton subjects divided into two groups accord-ing to placental maturation: low grade (Grannum 0-1; n=10) and high grade (Gran-num 2-3; n=24). In each study subjects, measurement was performed at two sites: (a) test site above the central part of the placenta, and (b) control site out of placenta on lower abdomen, in medial line, 3 cm from the symphysis. Student's t-test was used to compare tissue oxygenation index (TOI) values among the study groups. The normality of distribution was demonstrated by the Kolmogorov-Smirnov test.

NCT ID: NCT05759351 Completed - Pregnancy Related Clinical Trials

Appendectomy During Pregnancy and Child Development

Start date: January 1, 2006
Phase:
Study type: Observational

Maternal acute appendicitis during pregnancy is the most common abdominal surgical emergency. Long-term neurodevelopmental issues were scarcely reported. The aim of the study is to investigate the impact of appendicitis and appendectomy during pregnancy in general anesthesia on the cognitive and psychomotor development of children.

NCT ID: NCT05747989 Completed - Clinical trials for Carpal Tunnel Syndrome

A Comparison of Tissue Adhesive Material and Suture as Wound-closure Techniques Following Carpal Tunnel Decompression

Start date: June 1, 2022
Phase: N/A
Study type: Interventional

Participants will be randomly assigned to suture-based wound closure (n=50) or tissue adhesive-based wound closure (n=50) with two-component skin adhesive Glubran Tiss 2®. The outcomes will be assessed during the follow-up period at intervals of 2, 6, and 12 weeks postoperatively. A scar assessment will be using the POSAS (Patient and Observer Scar Assessment Scale) and cosmetic VAS (Visual Analog Scale). The VNRS (Verbal Number Rating Scale) will used to assess pain.

NCT ID: NCT05739357 Completed - Clinical trials for Postoperative Cognitive Dysfunction

Neurocognitive Function After Carotid Thrombendarterectomy

Start date: August 1, 2019
Phase: N/A
Study type: Interventional

Previous studies did not reach a consensus on the influence of the type of anesthesiologic procedure and monitoring, during carotid thrombendarterectomy, on perioperative complications and cognitive outcomes. The aim of this study is the optimization of brain perfusion during the vascular carotid clamp using multimodal monitoring. We assume that standardized monitoring techniques and a better selection of cognitive tests will allow a more accurate assessment of subclinical cognitive deficits.