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NCT ID: NCT03572777 Recruiting - Clinical trials for Helicobacter Pylori Infection

Comparison of Therapy in Treatment of Patients With Helicobacter Pylori Infection: Concomitant Versus Hybrid Therapy.

Start date: April 15, 2018
Phase: N/A
Study type: Interventional

The aim of the study is to compare the effectiveness of two therapeutic protocols in the treatment of Helicobacter pylori infection. The hypothesis of our research is that the two therapeutic options (hybrid and concomitant therapy) will be equally successful in the treatment of Helicobacter pylori infection. In other words, in both therapeutic groups we expect successful treatment of Helicobacter pylori infection in or more than 90 % of patients. In other studies, both therapeutic options have the same efficacy in treating H. pylori infection. On the other had there are no studies available in Croatia to compare the effectiveness of these therapeutic options so far, which is the main objective of our research. The secondary goals of our study will be: the existence of differences in the occurrence of possible side effects, as well as the compliance between patients in both therapeutic options. It is also our aim to compare the quality of life of patients with Helicobacter pylori infection before and after treatment, via a questionnaire that is common for this purpose. The study is expected to include a total of 174 patients (87 patients in each therapy group), and the planned duration is 6 months.

NCT ID: NCT03569293 Not yet recruiting - Atopic Dermatitis Clinical Trials

Evaluation of Upadacitinib in Adolescent and Adult Patients With Moderate to Severe Atopic Dermatitis (Eczema)- Measure Up 1

Start date: June 26, 2018
Phase: Phase 3
Study type: Interventional

The objective of this study is to assess the efficacy and safety of upadacitinib for the treatment of adolescent and adult participants with moderate to severe atopic dermatitis (AD) who are candidates for systemic therapy.

NCT ID: NCT03554252 Recruiting - Clinical trials for Health Knowledge, Attitudes, Practice

Comparison of Different Frames of Numerical Information in Cochrane Plain Language Summaries

Start date: April 1, 2018
Phase: N/A
Study type: Interventional

Participants will be randomly given one of two formats containing descriptions of health interventions. In one format, participants will have to read short summaries where results of the intervention are presented as frequencies and the side effects of health intervention are presented as percentages, while in another format the frames will be reversed (results will be presented as percentages and side effects as frequencies). After reading, participants will be asked several questions about the content of the summary and its conclusions.

NCT ID: NCT03553706 Completed - Clinical trials for Down Syndrome,Auxological Indexes, Auxological Parametars, Intrauterine Growth Restriction

Indicators of Growth, Nutritional Status and Comorbide Disorders of Newborns With Down Syndrome

DownSy
Start date: May 20, 2018
Phase:
Study type: Observational

Objective To access predictive values of the auxological parameters and indexes for risk of comorbid malformations in newborns with Down syndrome (DS) Study design In this cohort retrospective study, 141 newborns with proven trisomy 21 born at the Department of Gynecology and Obstetrics of the University of Split Hospital (1990 to 2015) were included. The data were obtained from the medical histories of mothers, infants and the delivery protocol. The objective was to access predictive values of the auxological parameters and indexes for risk of comorbid malformations in newborns with Down syndrome (DS) Conclusion Higher CI were found in hyportrophic (SGA) newborns with DS and indicated their intrauterine growth restriction with brain sparing and increased further risk of severe psychomotor retardation. The SGA newborns have lower parameters and indexes of nutritive status and significantly differed from eutrophic and hypertrophic newborns. These SGA newborns with DS have increased developmental risks and that requires further diagnostic attention.

NCT ID: NCT03551236 Completed - Healthy Subjects Clinical Trials

Variability of Impedance Pneumography Tidal Breathing Flow-volume Curves During Sleep in Healthy Children

Start date: January 17, 2017
Phase:
Study type: Observational

This is an observational study for the assessment of normal overnight variation in small healthy children using the Ventica Lung Function Testing System. The study is carried out to establish reference ranges for overnight lung function variation using the Ventica test, and to assess the impact of the demographic factors on the Ventica results.

NCT ID: NCT03542630 Recruiting - Infertility Clinical Trials

Evaluation of Matrix Metalloproteinase 8 Salivary Test for Diagnosis of Periodontitis

Start date: January 1, 2018
Phase:
Study type: Observational

Despite the great progress in understanding the causes of infertility, the reason for the failure of pregnancy has not been discovered among 25% of infertile couples. Some studies have shown the negative impact of periodontal disease on the reproductive potential of women. It is known that there is an elevated level of matrix metalloproteinase 8 (MMP8) in the gingival fluid of patients with periodontitis. It is possible to establish a fast diagnosis of periodontitis by using a non-invasive assay based on monoclonal antibodies to two epitopes of MMP-8. The goal of the research is to use the above described assay in order to compare the level of MMP8 in the gingival fluid of infertile patients with the control group of fertile women, depending on the existence of periodontal disease. It is expected to find significantly higher values of MMP8 in infertile patients in relation to the fertile patient with/without periodontitis. The prompt treatment of periodontitis in preconception care of this group of women could have a significant impact on the improvement of fertility and ability to achieve pregnancy.

NCT ID: NCT03542201 Recruiting - Clinical trials for Health Knowledge, Attitudes, Practice

Comparison of Blogshot Formats With Standard Cochrane Plain Language Formats

Start date: April 1, 2018
Phase: N/A
Study type: Interventional

Participants will receive in random order on format of brief description of systematic review summary on health intervention. One group will receive standard plain language summary, while another will receive Cochrane blog shot, containing only few information about the efficacy of the intervention. After reading, their task will be to answer several questions about the material they have read.

NCT ID: NCT03535909 Not yet recruiting - Clinical trials for Congestive Heart Failure

Hemodynamic Assessment in Acute Decompensated Heart Failure

Start date: July 2018
Phase:
Study type: Observational

This study will assess the ability of a novel optical measurement system to determine changes in the hemodynamic status of heart failure patients admitted to the hospital with a primary diagnosis of acute decompensated heart failure. Patients will be measured with both the novel measurement system and reference devices that are FDA-cleared for hemodynamic measurements. The measurements from the novel system will be compared to reference variables describing hemodynamic and congestive status, including stroke volume, central venous pressure, and serum levels of NT-proBNP.

NCT ID: NCT03534869 Completed - Clinical trials for Episiotomy; Complications

Auricular Acupuncture as Effective Pain Relief After Episiotomy

Start date: November 1, 2016
Phase: Phase 3
Study type: Interventional

Background: Episiotomy is performed in up to 30% of vaginal deliveries. Previously, pain treatment following episiotomy has relied on non-steroid anti-inflammatory drugs (NSAID) as analgesics, whose use during breastfeeding remains controversial due of their transfer to the child through lactation. The aim of the study is to determine the effect of acupuncture on postpartal perineal pain following episiotomy. Methods: The study is designed as a prospective interventional randomized parallel single-center study to evaluate the effects of auricular acupuncture on pain relief after episiotomy. The population will encompass 60 patients that have had mediolateral episiotomy performed during vaginal delivery, with 29 receiving acupuncture therapy and 31 not receiving acupuncture therapy for pain relief. NSAID analgesic therapy will be made available per request.

NCT ID: NCT03534791 Recruiting - Clinical trials for Knowledge Translation

Brief Reminders as Intervention for Greater Engagement of Cochrane Translators

Start date: May 1, 2018
Phase: N/A
Study type: Interventional

The intervention will consist of reminders which will be send to the participants randomly via email, with aim to increase the frequency and amount of translated plain language summaries (PLS).