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NCT ID: NCT06465030 Recruiting - Clinical trials for Recurrent Head and Neck Squamous Cell Carcinoma

Identification of Pattern and Factors Affecting Recurrence in Head and Neck Carcinoma

Start date: July 15, 2024
Phase:
Study type: Observational

The study will evaluate the local experiences in treatment of head and neck carcinoma by retrospectively analyzing the incidence and location of recurrence, and also studying factors affecting this recurrence.

NCT ID: NCT06464432 Recruiting - Clinical trials for Complex Post-Traumatic Stress Disorder

Complex-Posttraumatic Stress Disorder in Urban Egypt: Pilot Testing of a Culturally-adapted Evidence-Based Treatment Manual and Development of a Culture-specific Diagnostic

Start date: August 1, 2024
Phase: N/A
Study type: Interventional

Background: The CPTSD diagnosis presented in the ICD-11 is supposed to provide core and culturally invariant symptoms, which is supported by recent research. Yet, evidence also shows the necessity of integrating culture-specific symptoms in intervention and diagnostic tools to enhance the validity and efficacy of such diagnoses and therapeutic interventions. Along with cultural aspects, there are relevant structural aspects e.g., economic, and social inequalities, which impact mental health. These aspects remain understudied in low middle income countries like Egypt, where there are considerable rates of violence. Aims: The project aims to i) culturally adapt and pilot test the therapeutic manual ESTAIR/MPE in urban Egypt, and ii) to pilot test a cultural and structural module for the diagnostic assessment of CPTSD among the same target population. The objective is to assess the feasibility, acceptability, and initial impact on clinical outcomes of both the manual and diagnostic modules. Methods: In earlier phases, the project gathered qualitative data from key informants on the cultural and structural dimensions of CPTSD in urban Egypt. Using the collected data, investigators culturally adapted this intervention and developed a diagnostic cultural module. Subsequently, the investigators will pilot-test it in four groups of five participants each, 20 participants in total. The project intends to collect both quantitative and qualitative measures to explore determined outcomes and analyze them accordingly.

NCT ID: NCT06464263 Recruiting - Clinical trials for Valvular Cardiac Surgeries

Dexmedetomidine Versus Midazolam-Fentanyl for Analgesia and Sedation

Start date: February 10, 2024
Phase: N/A
Study type: Interventional

Postoperative sedation is an essential component in recovery of the patient undergoing cardiac surgery. It facilitates the patient's unawareness of the environment as well as reduce the discomfort and anxiety caused by surgery, intubation, mechanical ventilation, suction, and physiotherapy. Despite the advances in anesthesia and surgical techniques, the duration of mechanical ventilation (MV) may be prolonged after cardiac surgery, due to the classic high-dose narcotic-based cardiac anesthesia.

NCT ID: NCT06463574 Recruiting - Tooth Decay Clinical Trials

Effect of Aging on Micro-tensile Bond Strength and Color Stability of Self-adhesive Resin Composite

Start date: June 2024
Phase: N/A
Study type: Interventional

The objective of this study is to evaluate the micro-tensile bond strength of a newly self-adhesive resinous restorative material to dentin with and without application of universal bonding system (in-vitro) and to examine it's clinical performance by evaluation of it's color stability and marginal discoloration through a randomized clinical trial (in-vivo).

NCT ID: NCT06463379 Recruiting - Clinical trials for Refractory Juvenile Idiopathic Arthritis (Despite 2 DMARDs Still Active)

The Efficacy of Intravenous Pulse in Attaining Remission in Refractory Juvenile Idiopathic Arthritis

Start date: May 1, 2024
Phase: Phase 3
Study type: Interventional

Interventional phase 3 study aiming to unravel the value of pulse steroids in achieving remission or low disease activity in refractory active JIA

NCT ID: NCT06461767 Recruiting - Chronic Migraine Clinical Trials

Repetitive Transcranial Magnetic Stimulation in Treatment and Prophylaxis of Chronic Migraine in Patients With no Prophylactic Treatment for the Last 3 Months

rTMS
Start date: January 1, 2024
Phase: N/A
Study type: Interventional

Compared with the patients with episodic migraine those with chronic migraine have worst quality of life and more severe headache related disability we investigate Repetitive transcranial magnetic stimulation in treatment and prophylaxis of chronic migraine

NCT ID: NCT06459414 Recruiting - Prematurity Clinical Trials

Oropharyngeal Administration Of Colostrum For Preventing Necrotizing Enterocolitis in Preterrms

Start date: April 15, 2024
Phase: N/A
Study type: Interventional

Mother's milk samples will be collected during the routine expression of milk, using a hospital-grade electric breast pump, and will be stored in the NICU breastmilk refrigerator. The research doctor will prepare the syringes for the first 24 hours of the Initial Treatment Period. For neonates in the placebo group, the milk is immediately frozen, in a separate NICU breastmilk freezer to maintain blinding, for later use when enteral feedings are started. Using sterile gloves, oral syringes will be each filled with 1 mL/kg of colostrum or normal saline 0.9% (based on group assignment), capped, and covered with a white tape as a blinding procedure. Each syringe will be labeled with the patient's name, medical record number, and the date and time of preparation. Syringes will be prepared in the same sterile manner, by the research doctor, every 24 hours.

NCT ID: NCT06458465 Recruiting - Clinical trials for Chronic Kidney Disease

Impact of Curcumin and Pentoxiphylline on Chronic Kidney Disease Patients

CKD
Start date: October 1, 2023
Phase: N/A
Study type: Interventional

The aim of the study is to evaluate the impact of turmeric and pentoxiphylline on serum levels of protein-bound uremic toxin (p-cresyl sulfate), oxidative stress biomarker level (Malonaldehyde), inflammatory biomarker level (Highly sensitive C-reactive protein). In addition to the evaluation of its effect on metabolic profile and disease progression in chronic kidney disease patients.

NCT ID: NCT06458309 Recruiting - Spine Fracture Clinical Trials

Mangement of Spine Fracture

Start date: May 15, 2024
Phase: N/A
Study type: Interventional

Each year, there are approximately 5 million new vertebral fractures worldwide1. Most of these fractures involve the thoracolumbar or lumbar spines. The thoracolumbar junction, due to its mechanical transition zone, and the lumbar spine, due to its absence of stabilizing articulations with the ribs, lordotic posture and more sagittal oriented facet joints, are vulnerable for involvement in spinal injuries2. Burst fractures occurs frequently in high-energy traumas which are most commonly associated with falls and traffic accidents.3

NCT ID: NCT06458231 Recruiting - Clinical trials for Central Line-associated Bloodstream Infection (CLABSI)

Determining the Prevalence of Primary and Secondary Central Line Associated Blood Stream Infection (CLABSI) at the Tertiary Care Hospital

Microbiology
Start date: June 25, 2024
Phase:
Study type: Observational

- Review key history and clinical examination findings of cases with CLABSI. - Microbiological diagnosis and Culture sensitivity tests by automated Bact Alert and Vitek2c systems for CLABSI. - Determine antibiotic biogram of each organism isolated - Determine the prevalence of occurrence of Primary or secondary Blood stream infection, causing microorganism, and predisposing factors.