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NCT ID: NCT06334276 Not yet recruiting - Drowning Clinical Trials

Developing an Utstein-style Danish Drowning Registry: Nationwide Fatal and Nonfatal Drowning Data Since 2016

DROWN_INHOS
Start date: January 1, 2025
Phase:
Study type: Observational

This nationwide, registry-based study aims to link Danish Prehospital Drowning Data data with inhospital data to develop a Utstein-style Danish Drowning Registry. This study will report mortality and neurological outcomes 30 days after a drowning incident since 2016.

NCT ID: NCT06334003 Not yet recruiting - IVF Clinical Trials

Cardiometabolic Function in Offspring, Mother and Placenta After Assisted Reproductive Technology

COMPART
Start date: May 1, 2024
Phase:
Study type: Observational

The overall objective is to establish the first-of-its-kind longitudinal cohort of pregnant women, biological fathers/partners and offspring from pregnancies achieved by frozen embryo transfer (FET), fresh-embryo transfer (fresh ET) and naturally conceived (NC) to investigate maternal cardiometabolic profiles, fetal growth patterns and placental function during pregnancy as well as metabolic and endocrine health in the offspring. Additionally, the aim is to explore genetic and epigenetic patterns in placenta, fetus and parents. As secondary objectives, the investigator group will examine telomere length and minipuberty hormones in children born after FET, fresh-ET and NC.

NCT ID: NCT06333795 Not yet recruiting - Diarrhea Clinical Trials

Faecal Microbiota Transplantation Against Chronic Diarrhea in Patients With Systemic Sclerosis

FaeMiCue
Start date: April 1, 2024
Phase: N/A
Study type: Interventional

This clinical trial aims to assess the safety and effectiveness of faecal Microbiota Transplantation (FMT) in improving chronic diarrhea symptoms among patients with systemic sclerosis.

NCT ID: NCT06327893 Not yet recruiting - Drowning Clinical Trials

Patients Treated by the Danish Emergency Medical Services Following Non-drowning Water Rescues From 2016 to 2023

RESCUE
Start date: May 1, 2024
Phase:
Study type: Observational

Since 2015, all Danish prehospital EMS have used the nationwide Prehospital Electronic Medical Record (PEMR). In 2023, the investigators developed the Danish Drowning Formula (DDF), a text-search algorithm designed to search the unstructured text fields in the electronic medical records with comprehensive search criteria to identify all potential water-related incidents. This protocol describes the first study to analyse the prehospital data from a nationwide Danish cohort of patients treated by the EMS from 2016 to 2023 following non-drowning aquatic rescues.

NCT ID: NCT06325488 Not yet recruiting - Clinical trials for Chronic Kidney Diseases

Fibrosis, Inflammation, Oxygenation of Renal Tissue In FabrY Disease

FORTIFY
Start date: April 1, 2024
Phase:
Study type: Observational

The overall objective of this study is to investigate Fabry-associated renal organ involvement by using a novel magnetic resonance imaging (MRI) approach, focusing on changes in renal oxygen levels by blood oxygenation-level dependent (BOLD) imaging. Furthermore, to correlate renal oxygenation to the phenotypic presentation of patients with Fabry-associated nephropathy regarding circulating and imaging-derived biomarkers of kidney inflammation, fibrosis and injury as compared with healthy age- and sex-matched controls. The study will achieve this by: 1) Using a non-invasive, contrast-free MRI protocol focusing on parameters of oxygenation, inflammation, fibrosis, and injury in the kidney. 2) Using an extensive, in-depth biomarker blood panel to investigate the pathological pathways associated with Fabry disease and Fabry-associated nephropathy.

NCT ID: NCT06321432 Not yet recruiting - Obesity Clinical Trials

Intensive Weight Loss Intervention Versus Usual Care for Adults With Obesity

LightCARE
Start date: June 2024
Phase: N/A
Study type: Interventional

In this trial, the aim is to assess the clinical benefits and harms, as well as cost-effectiveness of an intensive weight loss (IWL) intervention that includes total dietary replacements, behavioural support and weight-loss medication compared with existing weight management programmes within primary care for people with obesity class I or uncomplicated obesity class II or higher.

NCT ID: NCT06318299 Not yet recruiting - Ketosis Clinical Trials

Effects of Exogenous Ketone Ester Supplementation on 3-hydroxybutyrate Concentrations in Human Cerebrospinal Fluid

KetoBrain
Start date: March 2024
Phase: N/A
Study type: Interventional

It is well established that the brain is capable of consuming ketone bodies, especially during low glucose availability, e.g. fasting. Cerebral metabolism of ketone bodies depends on passage of the blood brain barrier and especially the global blood concentration of ketone bodies. Ketone bodies can be administered exogenously, and the most commonly used in clinical trials is 3-hydroxybutyrate (3-OHB). 3-OHB is carried by simple diffusion and facilitated diffusion through several monocarboxylic acid transporters (MCTs) across the blood-brain barrier. To our knowledge, no studies in human adults exist that concurrently measure 3-OHB concentrations in blood and cerebrospinal fluid (CSF) after ingestion or infusion of exogenous ketone supplementation, necessitating further study. Aims: - The 3-OHB CSF/blood ratio after oral ingestion of 30 g ketone ester - primary endpoint - The window of effect: Ketone supplementation 1 h or 2 h before CSF sampling - If concentration measurements by point-of-care testing are non-inferior to mass spectrometry - If acute 3-OHB ingestion increases plasma brain-derived neurotrophic factor (BDNF) levels

NCT ID: NCT06314061 Not yet recruiting - Diabetes Mellitus Clinical Trials

The Effect of Continuous Glucose Monitoring in Surgical Patients With Diabetes.

WARD-glucose
Start date: April 1, 2024
Phase: N/A
Study type: Interventional

The goal of this randomised controlled trial to investigate the effect of continuous glucose monitoring (CGM) compared to standard point-of-care (POC) blood glucose measurements in surgical patients with diabetes in patients. The main question it aims to answer is: • Can the use of the CGM device Dexcom G7 with real-time alerts on dysglycaemia increase the time in range for glucose levels as compared with standard monitoring with point-of-care blood glucose in surgical patients with diabetes? Participants will be asked to wear a CGM device (Dexcom G7, Dexcom Inc.) during their stay in the hospital. For patients in the intervention group, deviations of glucose levels will provide the nursing staff with alerts. All patients will receive standard care of their diabetes. The CGM device will be worn for up to 10 days or until discharge.

NCT ID: NCT06312254 Not yet recruiting - Clinical trials for Peripheral Neuropathy

Pharmacological Modulation of Peripheral Nerve Excitability

Start date: April 2024
Phase: N/A
Study type: Interventional

The present project is a human experimental study. The aim is to assess the pharmacologically modulated excitability of peripheral sensory nerves with a human experimental model. The study measures the excitability of peripheral sensory nerves before and after application of different topical drugs (lidocaine (5%), phenytoin (10%),mepyramine (2%) and placebo).

NCT ID: NCT06312202 Not yet recruiting - Drowning Clinical Trials

Drowning Incidents in Danish Harbours

DROWN_HARBOR
Start date: May 1, 2024
Phase:
Study type: Observational

A recent study reported significantly increased mortality from drowning-related out-of-hospital cardiac arrest in Danish harbours compared to other public places (e.g., public pools, coastlines, and lakes). Accurate and reliable data are necessary before establishing specific educational, preventative, rescue, or treatment strategies to reduce the number of drowning incidents in Danish harbours and improve survival. Therefore, it is essential to characterise drowning incidents in Danish harbours and analyse risk factors associated with fatal drowning.