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NCT ID: NCT06368375 Completed - Clinical trials for Retinitis Pigmentosa

Clinical and Genetic Findings in Patients With PRPF31-associated Retinitis Pigmentosa

Start date: January 1, 2023
Phase:
Study type: Observational

Retrospective chart review study to elucidate the genotype and phenotype of patients with PRPF31-associated retinitis pigmentosa and asymptomatic carriers of the respective variant(s)

NCT ID: NCT06366568 Completed - Plaque, Dental Clinical Trials

Efficacy of a Eugenol-based Product to Improve the Quality of Toothbrushing and Relieving Gum Discomfort Areas

Start date: February 19, 2024
Phase: Phase 3
Study type: Interventional

The objective of this study is to evaluate the efficacy of a eugenol-based product in improving the quality of toothbrushing and relieving areas of gingival discomfort. This is a randomized, controlled, parallel, examiner-blind clinical trial.

NCT ID: NCT06358456 Completed - Healthy Clinical Trials

Influence of Artificial Tears on Keratometry and Biometry Measurements With Different Devices

Start date: November 20, 2020
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to learn about the influence of artificial tears on measurements of healthy eyes with three different devices. The main questions it aims to answer are: - Do artificial tears alter the measurements of the corneal surface - Is there a difference between the devices used in this study This is relevant because high quality measurements improve the postoperative outcome after cataract surgery.

NCT ID: NCT06333054 Completed - Head Lice Clinical Trials

Safety and Efficacy of a Head Lice Shampoo

Start date: October 13, 2014
Phase: N/A
Study type: Interventional

This study is designed to compare the effectiveness and safety of test head lice shampoo (Test product) versus Goldgeist® Forte (reference product) following two applications.

NCT ID: NCT06323499 Completed - Tachyarrhythmia Clinical Trials

Outcome of Induced Atypical Atrial Flutter

Start date: April 1, 2018
Phase:
Study type: Observational

Background: Atypical atrial flutter (AAF) is an increasingly relevant clinical problem. Despite advancements in mapping and ablation techniques, the general management of these patients remain challenging especially when mapping cannot be performed during ongoing arrhythmia. There are no data whether induction of AAF is a feasible approach in these cases. Methods: The investigators retrospectively analyzed patients who underwent catheter ablation of AAF and compared procedural results between patients with ongoing tachycardia when starting the procedure and patients with induced AAF. For this retrospective study, the investigators analyzed patients undergoing ablation of AAF between April 2018 and January 2021 that were identified from the ablation database at the West German Heart and Vascular Center, Essen. All patients were followed up in the outpatient clinic as part of the clinical standard routine or contacted by telephone to assess the occurrence of clinical recurrence of any arrhythmia. In case the documentation was not performed at the institution, relevant documents and ECGs were requested and reviewed. This single-center cohort study was conducted at the University Hospital Essen, Germany, in accordance with the Declaration of Helsinki and its amendments and was approved by the institutional review board of the University of Essen (number 21-10341-BO). Written informed consent was obtained from all study participants. The primary study endpoint was to evaluate the outcome of patients with induced AAF in comparison to patients with ongoing AAF when starting the procedure. Furthermore, the investigators analyzed the type of recurrence during follow-up as well as the occurrence and results of repeat ablations at the institution. The investigators also evaluated if the recurrent AAF form was the same or de-novo compared to the AAF during previous procedure.

NCT ID: NCT06322550 Completed - Clinical trials for Role-expectancy on Patient Reported Outcomes

Influence of Role-expectancy on Patient Reported Outcomes Among Patients With Migraine: a Randomized Clinical Trial

Start date: October 29, 2019
Phase: N/A
Study type: Interventional

This study was preregistered 2019 under https://osf.io/nczhj. Since JAMA requires a registration with ClinicalTrials.gov, we post-register the study here with the identical informations from OSF (see there) Migraine is frequently associated with motion sickness, vestibular symptoms, and abnormal motion and visual processing. Clinical symptoms and underlying brain mechanisms during self-motion visual stimulation were not yet investigated in this population. Therefore the aim is to investigate the behavioral responses from a visually simulated roller coaster ride of patients with migraine and headache-free controls. In order to verify the effect of response bias, part of the patients with migraine will be informed that the study aims to investigate vestibular disorders instead of headache disorders and that they are invited as healthy controls.

NCT ID: NCT06318208 Completed - Clinical trials for SARS-CoV-2 Infection

Pulmonary Function in Non-hospitalized Adults and Children After Mild COVID-19

Start date: April 20, 2021
Phase:
Study type: Observational

The study investigates whether patients with mild SARS-CoV-2 infection, who stayed at home during their infection and weren't hospitalized, have any persisting sequelae in pulmonary function. Therefore, 110 patients, aged 6-60 years, were recruited by telephone 4-12 weeks after laboratory-confirmed positive PCR and invited for a lung function testing. Every patient with abnormalities in pulmonary function was invited to a follow-up 3 months after the first appointment to assess changes in lung function values. Patients with a pre-existing lung disease and smokers within the last five years were excluded beforehand. Additionally to lung function testing we did a throat swab at each appointment to analyse via Multiplex PCR whether the patients had any other respiratory infection at the time of the pulmonary function testing.

NCT ID: NCT06312033 Completed - Emotion Regulation Clinical Trials

Estradiol's Effect on Brain Volume and Connectivity

Start date: August 1, 2018
Phase: N/A
Study type: Interventional

Ovarian hormones are not only modulators of cognitive function, emotion regulation and mental health, but also seem to affect brain plasticity and functional connectivity, During the menstrual cycle, women experience cyclic fluctuation of the ovarian hormone estradiol, which is closely associated with neuroplasticity/changes in brain structure in regions with high estradiol receptor density, such as the amygdala, hippocampus/parahippocampus, anterior cingulate cortex (ACC), striatum, and prefrontal cortex (PFC). Further functional connectivity between these areas seems to be associated with hormonal changes dependent on the menstrual cycle phase. But next to estradiol, also other hormones like progesterone fluctuate across the menstrual cycle. In the past, effects of ovarian hormone levels were often investigated in combination. However, one way to disentangle the impact of estradiol from that of other hormones on neuroplasticity, emotion regulation and mood states, can be the experimental increase of estradiol via estradiol administration. In this double-blinded within-subject study, women were administered either estradiol valerate or placebo during the early follicular phase (thus when ovarian hormone concentrations are low) before undergoing neuroimaging. Parts of the study are already described in Rehbein et al., 2021 and 2022.

NCT ID: NCT06309446 Completed - Wound Clinical Trials

Assessment of Wound Healing, Cooling Efficacy and Local Tolerability of a Wound Care Hydrogel

Start date: January 14, 2020
Phase: N/A
Study type: Interventional

Test the wound healing properties of the product as well as the cooling effect and tolerability of a wound care gel.

NCT ID: NCT06297668 Completed - Clinical trials for Chronic Obstructive Pulmonary Disease

A Study to Assess the Pharmacokinetics and Safety of Budesonide, Glycopyrronium, & Formoterol (BGF) Metered Dose Inhaler (MDI) Hydrofluoroolefin (HFO) With a Spacer (Treatment B), BGF MDI Hydrofluoroalkane (HFA) With a Spacer (Treatment A), as Well as BGF MDI HFO Without a Spacer (Treatment C).

Start date: April 29, 2024
Phase: Phase 1
Study type: Interventional

This study aims to assess the effect on total systemic exposure and to characterize exposure BGF MDI HFO with a spacer compared to without a spacer; also, to demonstrate that total systemic exposure of BGF when administered as MDI HFO with a spacer is not greater than BGF MDI HFA with a spacer.