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NCT ID: NCT04847011 Not yet recruiting - Healthy Clinical Trials

Deciphering the Impact of Exposures From the Gut Microbiome-derived Molecular Complex in Human Health and Disease

Start date: April 2021
Phase: N/A
Study type: Interventional

The ExpoBiome project will analyze the impact of fasting on patients with Parkinsons's Disease (PD) or rheumatoid arthritis (RA) on a clinical level as well as the effect of fasting on their immune system and gut microbiota. ExpoBiome will combine metagenomics and other "omics" [meta-transcriptomics, meta-proteomics and (meta-)metabolomics], bioinformatic analyses and biostatistics under a systems biology framework to gain new mechanistic insights into microbiome-immune system interactions in the context of chronic diseases with inflammatory signatures. Besides a one time crossectional study of healthy participants, patients with RA and PD a longitudinal fasting study with two arms (RA and PD) is planned.

NCT ID: NCT04846543 Recruiting - Forearm Fracture Clinical Trials

Bioresorbable Intramedullary Nailing of Forearm Fractures

Start date: March 1, 2021
Phase: N/A
Study type: Interventional

The Activa IM-Nailâ„¢ is used in the fixation of forearm fractures with cast to achieve a level of reduction and stabilisation that is appropriate to the age of the child. The post-market clinical follow-up study will be performed to identify the residual risk related to re-fracture and to determine its impact to the risk/benefit ratio of Activa IM-Nailâ„¢.

NCT ID: NCT04845841 Not yet recruiting - Clinical trials for Vasomotor Symptoms Associated With Sex Hormone-dependent Disorders in Women and Men

Comparison of the Extent to Which the Drug Given as Two Different Capsule Sizes Becomes Available to the Body

Start date: April 9, 2021
Phase: Phase 1
Study type: Interventional

Researchers are looking for a new way to treat women who have symptoms by hormonal changes, like those that happen in women during menopause. These symptoms can include hot flashes, night sweats, and changes in blood pressure. These symptoms are caused by hormonal changes occurring during menopausal transition when women may have also changes in their monthly cycles. The menopausal transition most often begins between ages 45 and 55 and leads to menopause, a point in time 12 months after a woman's last period. The study drug, elinzanetant, was designed to treat symptoms caused by hormonal changes. Before a new treatment can be approved for people to take, researchers perform clinical trials to better understand how this treatment works and to investigate safety. The purpose of this study is to assess the blood levels of elinzanetant when given as 2 capsules of dose A (what is intended for further research and future commercialization) and also to compare the blood levels when given as 3 capsules of dose B (what was used for research up to now). Furthermore, researchers want to find out if taking of elinzanetant on two time points leads to differences in blood levels of elinzanetant. This trial will be performed in healthy women aged 40 to 65 years.

NCT ID: NCT04845750 Not yet recruiting - Clinical trials for Cardiovascular Diseases

The RODEO Micro Mapping Catheter in Cryoablation Procedures

Start date: April 14, 2021
Phase: N/A
Study type: Interventional

This clinical investigation evaluates the feasibility of the Rodeo Micro Mapping Catheter in combination with cryoablation ssystem (sclerotherapy of muscle tissue of the heart by freezing) in patients with atrial fibrillation (permanent atrial fibrillation excepted). Further aims of this study are the evaluation of safety of the device and average procedure and fluoroscopy times.

NCT ID: NCT04845555 Recruiting - Hemophilia A Clinical Trials

Association Between Individual Clotting Factor Level Monitoring and the Risk of Bleeding Whilst Physical Active Conditions

Start date: September 1, 2019
Study type: Observational

The aim of this prospective multicentre study is to evaluate the influence of individual clotting factor level while being physically active

NCT ID: NCT04845503 Recruiting - Prostate Cancer Clinical Trials

Stereotactic MRI-guided Radiation Therapy for Localized prostatE Cancer

Start date: March 25, 2021
Phase: N/A
Study type: Interventional

As the most common carcinoma in men, prostate cancer is a significant tumor entity in oncology. In addition to the surgical approach, definitive radiotherapy is an equivalent therapy alternative in the non-metastatic primary situation. However, radiotherapy usually stretches over a period of several weeks (7 to 8 weeks) during which the patient receives irradiation on a daily basis. For this reason and for radiobiological considerations the total treatment time is increasingly shortened. It has been shown in several randomized phase III studies that shorting radiotherapy to about 4 weeks by increasing the single dose (so-called hypofractionation) is possible. Meanwhile there is also more data on extreme hypofractionation (max. 10 radiation sessions) available, however often times, extensive preparations are necessary (such as the invasive introduction of markers into the prostate). The current, prospective, non-randomized, multicentric, Phase II SMILE study is now testing whether the MRI-guided radiotherapy with a greatly shortened radiotherapy of the prostate over 5 radiation sessions is possible and safe.

NCT ID: NCT04844944 Not yet recruiting - Clinical trials for Coronary Artery Disease

The Helios Heart Registry: A Standardized Registry for Patients With Specific Cardiac Diseases

Start date: June 1, 2021
Study type: Observational [Patient Registry]

Investigator-initiated, prospective, non-randomized, open label, non-interventional multicenter registry to evaluate current treatment of three major cardiovascular disease entities in clinical practice using a standardized variable-set of relevant covariates and outcome measures.

NCT ID: NCT04844931 Not yet recruiting - Clinical trials for ST Elevation Myocardial Infarction

Remote Ischemic Conditioning With Local Ischemic Postconditioning in High-Risk ST-elevation Myocardial Infarction

Start date: May 1, 2021
Phase: N/A
Study type: Interventional

The RIP-HIGH trial is a two-arm randomized controlled trial aiming to compare the impact of combined remote ischemic conditioning (RIP) and local ischemic postconditioning (PostC) vs. standard of care on clinical outcome in high-risk ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention.

NCT ID: NCT04844723 Recruiting - Anesthesia Clinical Trials

Pediatric Videolaryngoscopic Intubation and Difficult Airway Classification

Start date: April 12, 2021
Study type: Observational

The study's primary aim is to develop and validate a multivariable diagnostic model for the prediction of difficult videolaryngoscopy (the 'PeDiAC classification') in children undergoing general anesthesia with tracheal intubation. The secondary aim is to compare the diagnostic performance of the PeDiAC-classification with the Cormack-Lehane classification.

NCT ID: NCT04843202 Active, not recruiting - Clinical trials for Preoperative Evaluation

Clinical Guidelines in Premedication Visit

Start date: June 1, 2018
Study type: Observational

The purpose of the study is to determine the frequency with which individual guideline recommendations on preoperative evaluation of patients scheduled for non-cardiac surgery are implemented as well as identifying the guidelines that are most frequently violated.