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NCT ID: NCT03809962 Not yet recruiting - Coxarthrosis Clinical Trials

Efficacy and Safety of Ostenil® Plus in the Treatment of Coxarthrosis

Start date: January 2019
Phase:
Study type: Observational

PMCF study to observe the Routine application of Ostenil® Plus in the Treatment of pain and restricted mobility in degenerative and traumatic changes of the Hip Joint.

NCT ID: NCT03809325 Recruiting - Schizophrenia Clinical Trials

A Survey to Collect Treatment Experience Feedback From Patients, Physicians, Nurses and Carers After Switching to Paliperidone Palmitate 3-monthly

Start date: November 21, 2018
Phase:
Study type: Observational

The purpose of this study is to explore the experience with paliperidone palmitate 3-month formulation (PP3M) treatment of participants and their corresponding physicians, nurses and carers, to understand the impact of less frequent injections from their perspective.

NCT ID: NCT03808948 Enrolling by invitation - CHF Clinical Trials

FAST PV and mGFR™ Technology in Congestive Heart Failure

Start date: January 10, 2019
Phase: N/A
Study type: Interventional

This is an investigator-initiated, one-armed, phase 2 clinical trial using an injectable fluorescent tracer to assay and evaluate measured plasma volume (mPV) and measured glomerular filtration rate (mGFR) in hospitalized patients with acute decompensated congestive heart failure (CHF).

NCT ID: NCT03808623 Recruiting - Cartilage Diseases Clinical Trials

Non-interventional Study With NOVOCART® Basic in Patients Treated for Cartilage Defects in the Knee With AMIC

NBasic
Start date: April 9, 2018
Phase:
Study type: Observational

Retrospective, multicenter, single arm, non-interventional study to assess the safety and Performance of NOVOCART Basic and the clinical outcome of AMIC with NOVOCART Basic in patients treated for cartilage defects in the knee.

NCT ID: NCT03808142 Not yet recruiting - Multiple Sclerosis Clinical Trials

PROmyBETAappGame: a Study to Learn More About the Medication Usage & Patient Reported Outcomes Via the myBETAapp and to Find Out More About the Usage of Game Principles and Game Design Elements (Gamification) in Medical Care of Patients With Multiple Sclerosis Treated With Betaferon

Start date: January 15, 2019
Phase:
Study type: Observational

In this study researchers want to learn more about the medication usage behavior among multiple sclerosis (MS) patients treated with Betaferon using the myBETAapp which includes the elements to what extent - taking medication matches the presciber´s recommendation (adherence, compliance), - treatment for the prescribed duration (persistence) is continued and - injections were missed. Among MS patients treated with Betaferon using the myBETAapp the study will also collect information on the health-related quality of life , treatment satisfaction and satisfaction with treatment support.

NCT ID: NCT03808012 Not yet recruiting - Inguinal Hernia Clinical Trials

Predictability of the Ability to Perform an Emergency Stop After Surgery for Inguinal Hernia

Start date: February 10, 2019
Phase: N/A
Study type: Interventional

Several studies exist on patient performance in drive simulators especially around and after surgery. Recommendations concerning the ability to drive after inguinal hernia are scarce and so far do not offer conclusive results. Aim of the study is to analyse reaction time and foot transfer time (together brake response time) and brake force in a brake simulator before and after scheduled inguinal hernia surgery (Liechtenstein procedure).

NCT ID: NCT03807479 Recruiting - Clinical trials for Leukemia, Myeloid, Chronic-Phase

A Study in Patients With Chronic Leukemia, Where Previous Therapy Failed, and Who Will be Treated With Ponatinib as Second Line Therapy (PONS).

PONS
Start date: December 11, 2018
Phase: Phase 2
Study type: Interventional

This study will include patients suffering from chronic myeloid leukemia (CP-CML), who were treated with tyrosine kinase inhibitor (TKI, a substance that blocks the action of enzymes) in a previous therapy but which has not been effective. Patients will be treated with Ponatinib 30 mg in in this study. The aim of the study is to evaluate the safety and efficacy of Ponatinib as a second line treatment in patients failing or not tolerating first line therapy with any other approved TKIs. It is expected that Ponatinib, due to its efficacy, may be more effective as second line therapy than other approved TKIs and lead to improved overall survival. The effect will be determined by the molecular response rate (MMR) as the primary objective after 12 months of treatment. The safety of the drug will be evaluated on the basis if routine medical and laboratory examinations.

NCT ID: NCT03806920 Recruiting - Clinical trials for Diabetes Mellitus, Type 2

Isomaltulose VS Sucrose - Postprandial Effect on Incretin Profile and Second Meal Effect

Start date: November 5, 2016
Phase: N/A
Study type: Interventional

This study evaluates the different postprandial effect of isomaltulose and sucrose on the incretin profile and as an determinant for the second meal effect. In this nutritional intervention study, healthy participants and T2DM patients ingest 2 standardized meals for breakfast and lunch in combination with either sucrose or palatinose on 2 separate days. In addition, blood samples are taken to analyze markers of the carbohydrate metabolism, incretins and specific inflammation markers.

NCT ID: NCT03806569 Not yet recruiting - Psychotherapy Clinical Trials

MAC-cbt Group Therapy for Adults With ADHD

Start date: February 1, 2019
Phase: N/A
Study type: Interventional

The study is developed to validate a new short psychotherapeutic group treatment for adults with ADHD diagnosis. The participants will be treated in a monocentric, parallel group randomized superiority study - one group with the new treatment and one group with well established relaxing treatment.

NCT ID: NCT03805854 Recruiting - Clinical trials for Experimental Pain in Healthy Human Subjects

Modulating Pain Using Transcranial Alternating Stimulation (tACS) in Healthy Human Subjects

Start date: January 2019
Phase: N/A
Study type: Interventional

Pain is a highly complex and subjective phenomenon which results from the dynamic integration of sensory and contextual (i.e. cognitive, emotional, and motivational) processes. Recent evidence suggests that neural oscillations and their synchronization between different brain areas might form the basis of these integrative functions. When investigating tonic experimental pain lasting for several minutes, for example, objective stimulus intensity is inversely related to alpha (8-13 Hz) and beta (13-30 Hz) oscillations in early somatosensory areas, while subjective pain intensity is positively associated with gamma (30-100 Hz) oscillations in prefrontal cortex. Yet, with a few exemptions, reported links between oscillatory brain activity and pain have mostly been established by correlative approaches which do not allow to infer causality. The current project aims at comprehensively investigating the causal role of neural oscillations for tonic experimental pain in healthy human subjects. To this end, transcranial alternating current stimulation (tACS) will be employed to modulate oscillatory brain activity in alpha and gamma frequency bands and investigate effects of this manipulation on pain perception and pain-related autonomic responses. Using an established tonic pain stimulation protocol and a double-blind, sham-controlled design, effects of tACS of somatosensory as well as prefrontal brain areas will be investigated. Results promise to elucidate the neural mechanisms underlying tonic experimental pain by testing the mechanistic role of neural oscillations in different aspects of pain processing. Furthermore, they might contribute to the development of urgently needed new treatment approaches for chronic pain using neuromodulatory methods.