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NCT ID: NCT05252273 Suspended - Ulcerative Colitis Clinical Trials

Assessment of Patients With Acute Pouchitis Treated With Antibiotics

Start date: December 7, 2021
Phase:
Study type: Observational [Patient Registry]

The purpose of this study is to evaluate the reliability and responsiveness of symptoms, endoscopic, and histological items for assessing pouchitis disease activity in patients undergoing standard of care (SOC) antibiotic therapy for treatment of pouchitis, in order to develop a novel pouchitis disease activity index.

NCT ID: NCT05230394 Suspended - Sleep Apnea Clinical Trials

Patient Outcomes in Unattended and In- Lab Polysomnography

Start date: August 2023
Phase: N/A
Study type: Interventional

This randomized controlled study will directly evaluate whether unattended polysomnography (level 2 sleep study) in individuals referred for sleep apnea or hypersomnia, including those with comorbidities of insomnia and sleep-related movement disorders, provides similar patient outcomes when compared to level 1 sleep studies.

NCT ID: NCT05212727 Suspended - Clinical trials for Neurological Disorders

Development and Validation of a Novel Functional Eye-Tracking Software Application for Neurological Disorders

Start date: April 15, 2022
Phase:
Study type: Observational

This study aims to develop and validate a sensitive and non-invasive eye-tracking software application. This study will obtain participant responses to brief cognitive tests designed to evaluate several key functions known to be affected by neurological disorders and non-invasive eye movement measurements in response to visually presented stimuli during specifically designed eye-tracking tests. The study data will be used to develop machine learning algorithms and validate a software application intended to track the progressive component of neurological disorders and associated cognitive changes.

NCT ID: NCT05210933 Suspended - Renal Cancer Clinical Trials

Study of Minimally-invasive Ablative Renal Therapies (SMART) Registry

SMART
Start date: April 1, 2022
Phase:
Study type: Observational [Patient Registry]

Multi-center prospective cohort study examining curative intent renal cryotherapy and radiofrequency ablation for small renal mass treatment in patients who are poor candidates for surgical resection, We will capture clinical, radiological, and pathological data as well as resource utilization (ex: time in hospital, ER visits), complications, and long-term functional and oncological outcomes. The investigators will also be biobanking blood and urine samples from participants for biological studies in the lab.

NCT ID: NCT05178862 Suspended - Candidemia Clinical Trials

A Phase 3, Randomized, Double-blind Study for Patients With Invasive Candidiasis Treated With IV Echinocandin Followed by Either Oral Ibrexafungerp or Oral Fluconazole

MARIO
Start date: August 3, 2022
Phase: Phase 3
Study type: Interventional

This is a multicenter, randomized, double-blind study of two treatment regimens for invasive candidiasis included candidemia. Subjects will receive intravenous echinocandin followed by oral ibrexafungerp (SCY-078) vs intravenous echinocandin followed by oral fluconazole.

NCT ID: NCT05109754 Suspended - COPD Clinical Trials

Home Non-Invasive Ventilation Targeting Expiratory Flow Limitation in Severe Hypercapnic COPD.

Start date: October 2025
Phase: N/A
Study type: Interventional

In this 2-phase pilot study, the BiPAP A40 EFL will be evaluated in patients with severe COPD requiring home non-invasive ventilatory support with respect to patient-related and physiologic outcomes.

NCT ID: NCT05096403 Suspended - Clinical trials for Cold Agglutinin Disease

A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Patients With Cold Agglutinin Disease (CAD)

Start date: October 20, 2022
Phase: Phase 3
Study type: Interventional

The purpose of the study is to determine the efficacy of pegcetacoplan administration compared to placebo in increasing hemoglobin (Hgb) level from baseline and avoiding transfusion in participants with primary cold agglutinin disease (CAD).

NCT ID: NCT04920396 Suspended - Clinical trials for Meibomian Gland Dysfunction

Intense Regulated Pulsed Light Vs Standard of Care for the Treatment of Meibomian Gland Dysfunction

Start date: June 8, 2021
Phase: N/A
Study type: Interventional

This study is to evaluate the effectiveness of E>EYE intense regulated pulsed light (IRPL) treatment compared to the current standard of care using a daily warm compress

NCT ID: NCT04896827 Suspended - Chronic Pain Clinical Trials

DNIC Using Deep Learning and Artificial Intelligence

Start date: April 5, 2022
Phase:
Study type: Observational

Chronic pain (CP) is disabling for people triggering important costs for society. A deficit of diffuse noxious inhibitory controls (DNIC) is one of the CP mechanisms. DNICs are evaluated in research setting using a CPM protocol (conditioned pain modulation). There is a lack of reference values on the effectiveness of DNICs. Wider research on DNIC will help to understand CP and to develop a clinical screening test evaluating DNICs. This study aims more specifically to determine whether it is possible to develop a facial recognition system to automate pain measurement and the effectiveness of pain control mechanisms.

NCT ID: NCT04893382 Suspended - Burns Clinical Trials

Inflammatory Consequences of Crystalloids in Severely Burned Patients

Start date: October 17, 2021
Phase: N/A
Study type: Interventional

This is a pilot study, but the investigators will also observe key immunological events with potential significance. The global objective is to study the inflammatory profiles of PlasmaLyte and Ringer's Lactate used in the initial massive fluid resuscitation of severely burned patients. On the long term, the investigators will identify the crystalloid that prevents hyperactivation of macrophages and death of severely burned patients.