Coronary Artery Disease Clinical Trial
Official title:
Randomized Comparison Between Sirolimus-eluting and Everolimus-eluting Coronary Stents in Chronic Coronary Occlusions
Chronic total coronary occlusions (CTO) have an especially high risk of angiographic
restenosis, and need for new revascularization procedures. Drug-eluting coronary stents
(DES) have demonstrated to significantly reduce the risk of restenosis and new
revascularization procedures in comparison with bare-metal stents.
Most data on the efficacy of DES come from the sirolimus-eluting coronary stent Cypher
(Cordis corp.), and paclitaxel-eluting coronary stent Taxus (Boston Sci.), and the Cypher
stent is the only DES that has been randomly tested in CTO. Among second-generation DES,
everolimus-eluting stent (EES) has shown excellent angiographic and clinical results, but
this DES has not been studied in unfavourable scenario (such as CTO).
The aim of the CIBELES trial is to demonstrate the hypothesis that EES are equally effective
in comparison with sirolimus-eluting stents in the treatment of CTO, in terms of
angiographic efficacy considered as in-stent late lumen loss.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Outcomes Assessor), Primary Purpose: Treatment
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