Coronary Heart Disease (CHD) Clinical Trial
— VESALIUS-CVOfficial title:
A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Impact of Evolocumab on Major Cardiovascular Events in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke
| Verified date | May 2024 |
| Source | Amgen |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | |
| Study type | Interventional |
This study will assess the effect of lowering low-density lipoprotein cholesterol (LDL-C) with evolocumab on major cardiovascular events in adults without a prior myocardial infarction (MI) or stroke who are at high risk of a cardiovascular event.
| Status | Active, not recruiting |
| Enrollment | 12301 |
| Est. completion date | July 26, 2025 |
| Est. primary completion date | July 26, 2025 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 50 Years to 79 Years |
| Eligibility | Inclusion criteria: 1. Age: Adult subjects = 50 (men) or = 55 (women) to ? 80 years of age (either sex) and meeting lipid criteria 2. Low-density lipoprotein cholesterol (LDL-C) = 90 mg/dL (= 2.3 mmol/L) or non-high-density lipoprotein cholesterol (non-HDL) = 120 mg/dL (= 3.1 mmol/L), or apolipoprotein B = 80 mg/dL (= 1.56 µmol/L) 3. Evidence of at least one of the following at screening (without prior myocardial infarction or stroke): A. Significant coronary artery disease (CAD) B. Significant atherosclerotic cerebrovascular disease C. Significant peripheral arterial disease D. Diabetes mellitus 4. At least 1 high-risk feature Exclusion criteria - MI or stroke prior to randomization - Coronary artery bypass grafting (CABG) ? 3 months prior to screening - Estimated glomerular filtration rate (eGFR) ? 15 mL/min/1.73 m² - Uncontrolled or recurrent ventricular tachycardia in the absence of an implantable-cardioverter defibrillator. - Atrial fibrillation or atrial flutter not on anticoagulation therapy (vitamin K antagonist, heparin, low molecular weight heparin, fondaparinux,or non-Vitamin K antagonist oral anticoagulant) - Triglycerides = 500 mg/dL (5.7 mmol/L) measured up to 3 months prior to screening. The most recent results must be used. - Last measured left-ventricular ejection fraction ? 30% or New York Heart Association (NYHA) Functional Class III/IV - Planned arterial revascularization |
| Country | Name | City | State |
|---|---|---|---|
| Argentina | Instituto de Investigaciones Clinicas Bahia Blanca | Bahia Blanca | Buenos Aires |
| Argentina | Cardiología Palermo | Caba | Buenos Aires |
| Argentina | Cedic - Centro de Investigacion Clinica | Caba | Buenos Aires |
| Argentina | Centro de Especialidades Medicas - Cemedic | Caba | Buenos Aires |
| Argentina | Centro Medico Dra De Salvo | Caba | Buenos Aires |
| Argentina | Centro Medico Laura Maffei | Caba | Buenos Aires |
| Argentina | Cinme - Centro de Investigaciones Metabolicas | Caba | Buenos Aires |
| Argentina | Ciprec - Centro de Investigacion y Prevencion Cardiovascular | Caba | Buenos Aires |
| Argentina | Consultorio Medico Dr Litvak Bruno | Caba | Buenos Aires |
| Argentina | Fundacion Respirar | Caba | Buenos Aires |
| Argentina | Stat Research | Caba | Buenos Aires |
| Argentina | Glenny Corp SA | Ciudad Autonoma de Buenos Aires | Buenos Aires |
| Argentina | Hospital Universitario Fundacion Favaloro | Ciudad Autonoma de Buenos Aires | Buenos Aires |
| Argentina | Icba - Instituto Cardiovascular de Buenos Aires | Ciudad Autonoma de Buenos Aires | Buenos Aires |
| Argentina | Instituto de Investigaciones Metabolicas - Idim | Ciudad Autonoma de Buenos Aires | Buenos Aires |
| Argentina | Clinica Privada del Prado | Cordoba | Córdoba |
| Argentina | Instituto Medico DAMIC - Fundacion Rusculleda | Córdoba | |
| Argentina | Instituto de Cardiologia de Corrientes Juana Francisca Cabral | Corrientes | |
| Argentina | Instituto de Investigaciones Clinicas Mar del Plata | Mar del Plata | Buenos Aires |
| Argentina | Ciad - Consultorio Integral de Atencion al Diabetico | Moron | Buenos Aires |
| Argentina | Dim Clinica Privada | Ramos Mejia | Buenos Aires |
| Argentina | Instituto de Investigaciones Clínicas Rosario-Sanatorio Delta | Rosario | Santa Fe |
| Argentina | Sanatorio Plaza | Rosario | Santa Fe |
| Argentina | Cordis Sa | Salta | |
| Argentina | Clinica El Castano | San Juan | |
| Argentina | Instituto Cardiovascular San Luis | San Luis | |
| Argentina | Centro Modelo de Cardiologia | San Miguel de Tucuman | Tucuman |
| Argentina | Clinical Mayo de Urgencias Medicas Cruz Blanca SRL | San Miguel de Tucuman | Tucuman |
| Argentina | Instituto de Investigaciones Clinicas de San Nicolas | San Nicolas | Buenos Aires |
| Argentina | Centro de Investigaciones Clinicas del Litoral | Santa Fe | |
| Argentina | Sanatorio Santa Rosa Srl | Santa Rosa | La Pampa |
| Argentina | Clinica Fusavim Privada SRL | Villa Maria | Córdoba |
| Argentina | Instituto de Investigaciones Clinicas Zarate | Zarate | Buenos Aires |
| Australia | Heart and Vascular Research | Adelaide | South Australia |
| Australia | Royal Adelaide Hospital | Adelaide | South Australia |
| Australia | SA Heart | Ashford | South Australia |
| Australia | Heartcare Partners | Auchenflower | Queensland |
| Australia | Curtin University Centre of Clinical Research and Education | Bentley | Western Australia |
| Australia | HeartCare Victoria - Berwick | Berwick | Victoria |
| Australia | Bundaberg Cardiology | Bundaberg | Queensland |
| Australia | Royal Prince Alfred Hospital | Camperdown | New South Wales |
| Australia | Monash Medical Centre | Clayton | Victoria |
| Australia | The Cardiologists Proprietary Limited | Epping | Victoria |
| Australia | Holdsworth House Medical Brisbane | Fortitude Valley | Queensland |
| Australia | Canberra Hospital | Garran | Australian Capital Territory |
| Australia | Barwon Health Geelong Hospital | Geelong | Victoria |
| Australia | Royal Hobart Hospital | Hobart | Tasmania |
| Australia | HeartCare Western Australia - Joondalup | Joondalup | Western Australia |
| Australia | Adelaide Cardiology Practice - Leabrook Clinic | Leabrook | South Australia |
| Australia | Liverpool Hospital | Liverpool | New South Wales |
| Australia | Australian Clinical Research Network | Maroubra | New South Wales |
| Australia | Core Research Group Pty Ltd | Milton | Queensland |
| Australia | Fiona Stanley Hospital | Murdoch | Western Australia |
| Australia | GenesisCare Ringwood | Ringwood | Victoria |
| Australia | Dr Heart Pty Ltd | Woolloongabba | |
| Austria | Landeskrankenhaus Feldkirch | Feldkirch | |
| Austria | Medizinische Universitaet Graz | Graz | |
| Austria | Medizinische Universitaet Innsbruck | Innsbruck | |
| Austria | Klinikum Klagenfurt am Woerthersee | Klagenfurt | |
| Austria | Ordensklinikum Linz Barmherzige Schwestern | Linz | |
| Austria | Klinik Hietzing | Wien | |
| Austria | Klinik Landstrasse | Wien | |
| Austria | Klinik Ottakring | Wien | |
| Austria | Universitaetsklinikum Allgemeines Krankenhaus Wien | Wien | |
| Austria | Zentrum fuer klinische Studien - Dr Hanusch GmbH | Wien | |
| Belgium | Algemeen Stedelijk Ziekenhuis Aalst | Aalst | |
| Belgium | Onze Lieve Vrouw Ziekenhuis - campus Aalst | Aalst | |
| Belgium | Ziekenhuis Netwerk Antwerpen Middelheim | Antwerpen | |
| Belgium | Ziekenhuis Netwerk Antwerpen Stuivenberg | Antwerpen | |
| Belgium | Universite Catholique de Louvain Cliniques Universitaires Saint Luc | Bruxelles | |
| Belgium | AZ Sint Blasius | Dendermonde | |
| Belgium | Algemeen Ziekenhuis Sint Lucas | Gent | |
| Belgium | Medif sprl | Gozee | |
| Belgium | Dokter Mortelmans bvba | Ham | |
| Belgium | Jessa Ziekenhuis - Campus Virga Jesse | Hasselt | |
| Belgium | Universitair Ziekenhuis Leuven - Campus Gasthuisberg | Leuven | |
| Belgium | Medilink sprl | Linkebeek | |
| Belgium | Centre Hospitalier Universitair Ambroise Pare | Mons | |
| Belgium | Maria Ziekenhuis Noord-Limburg | Pelt | |
| Belgium | Testumed vzw | Tessenderlo | |
| Brazil | Cardresearch Cardiologia Assistencial de Pesquisa | Belo Horizonte | Minas Gerais |
| Brazil | Fundaçao Hospitalar Sao Francisco de Assis | Belo Horizonte | Minas Gerais |
| Brazil | AngioCor Blumenau | Blumenau | Santa Catarina |
| Brazil | Centro de Pesquisa Clinica do Brasil | Brasília | Distrito Federal |
| Brazil | Sociedade Hospitalar Angelina Caron | Campina Grande do Sul | Paraná |
| Brazil | Centro Especializado em Cardiologia | Campinas | São Paulo |
| Brazil | Instituto de Pesquisa Clinica de Campinas | Campinas | São Paulo |
| Brazil | Nucleo de Pesquisa Clinica | Curitiba | Paraná |
| Brazil | Puc Trials - Núcleo de Pesquisa Clínica da Escola de Medicina da Pucpr/Epicenter | Curitiba | Paraná |
| Brazil | Quanta Diagnosticos e Terapia | Curitiba | Paraná |
| Brazil | Centro de Pesquisas em Diabetes e Doencas Endocrino Metabolicas | Fortaleza | Ceará |
| Brazil | Instituto do Coracao de Marilia | Marilia | São Paulo |
| Brazil | Hospital Nossa Senhora da Conceicao | Porto Alegre | Rio Grande Do Sul |
| Brazil | Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul | Porto Alegre | Rio Grande Do Sul |
| Brazil | Núcleo de Pesquisa em Cirurgia Vascular | Porto Alegre | Rio Grande Do Sul |
| Brazil | IBPClin Instituto Brasil de Pesquisa Clinica | Rio de Janeiro | |
| Brazil | Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto | São José do Rio Preto | São Paulo |
| Brazil | Centro de Pesquisas Clinicas Cpclin | Sao Paulo | São Paulo |
| Brazil | Instituto do Coracao do Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo | São Paulo | |
| Brazil | Eurolatino Pesquisas Medicas | Uberlandia | Minas Gerais |
| Bulgaria | Ambulatory for special outpatient medical aid in Cardiology-Private Practice Dr Elena Dotcheva EOOD | Burgas | |
| Bulgaria | Multiprofile Hospital for Active Treatment - Haskovo AD | Haskovo | |
| Bulgaria | Specialty Hospital for Active treatment in Cardiology Sveti Georgi - Pernik OOD | Pernik | |
| Bulgaria | Medical Center Medconsult OOD | Pleven | |
| Bulgaria | University Multiprofile Hospital for Active Treatment Dr Georgi Stranski EAD | Pleven | |
| Bulgaria | Multiprofile Hospital for Active Treatment- Medical Complex- Sveti Ivan Rilski EOOD | Plovdiv | |
| Bulgaria | University Multiprofile Hospital for Active Treatment Sveti Georgi EAD | Plovdiv | |
| Bulgaria | Acibadem City Clinic Multiprofile Hospital for Active Treatment Tokuda EAD | Sofia | |
| Bulgaria | Diagnostic-Consultative Center Convex EOOD | Sofia | |
| Bulgaria | Fifth Multiprofile Hospital for Active Treatment - Sofia EAD | Sofia | |
| Bulgaria | Medical Center Excelsior OOD | Sofia | |
| Bulgaria | Medical Center for Specialized Medical Care of Cardiovascular Diseases OOD | Sofia | |
| Bulgaria | Medical Center Kalimat EOOD | Sofia | |
| Bulgaria | Multiprofile Hospital for Active Treatment Sveta Anna Sofia AD | Sofia | |
| Bulgaria | National Multiprofile Transport Hospital Tzar Boris III | Sofia | |
| Bulgaria | University Multiprofile Hospital for Active Treatment and Emergency Medicine N I Pirogov EAD | Sofia | |
| Bulgaria | University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna - ISUL EAD | Sofia | |
| Bulgaria | Medical Center Orpheus OOD | Stara Zagora | |
| Bulgaria | Multiprofile Regional Hospital for Active Treatment Dr Stefan Cherkezov AD | Veliko Tarnovo | |
| Canada | Heart Health Institute | Ajax | Ontario |
| Canada | LMC Clinical Research Incorporated | Barrie | Ontario |
| Canada | Brampton Clinical Trials | Brampton | Ontario |
| Canada | LMC Clinical Research Incorporated | Brampton | Ontario |
| Canada | LMC Clinical Research Incorporated | Calgary | Alberta |
| Canada | Ecogene-21 | Chicoutimi | Quebec |
| Canada | LMC Clinical Research Incorporated Thornhill | Concord | Ontario |
| Canada | LMC Clinical Research Incorporated | Etobicoke | Ontario |
| Canada | Queen Elizabeth II Health Sciences Centre, Halifax Infirmary | Halifax | Nova Scotia |
| Canada | Hamilton Health Sciences Hamilton General Hospital | Hamilton | Ontario |
| Canada | Manna Research Incorporated | Levis | Quebec |
| Canada | Western Centre for Public Health and Family Medicine - Western University | London | Ontario |
| Canada | My Endo Diabetes and Endocrinology Center | Markham | Ontario |
| Canada | G A Research Associates Limited | Moncton | New Brunswick |
| Canada | Applied Medical Informatics Research Incorporated | Montreal | Quebec |
| Canada | Clinique Sante Cardio MC | Montreal | Quebec |
| Canada | Institut de recherches cliniques de Montreal | Montreal | Quebec |
| Canada | McGill University Health Centre - Montreal General Hospital | Montreal | Quebec |
| Canada | Commonwealth Medical Clinic | Mount Pearl | Newfoundland and Labrador |
| Canada | LMC Clinical Research Incorporated | Nepean | Ontario |
| Canada | Partners in Advanced Cardiac Evaluation | Newmarket | Ontario |
| Canada | SKDS Research Incorporated | Newmarket | Ontario |
| Canada | Oakville Cardiovascular Research | Oakville | Ontario |
| Canada | Dr James Cha | Oshawa | Ontario |
| Canada | Kawartha Cardiology Clinical Trials | Peterborough | Ontario |
| Canada | Clinique des Maladies Lipidiques de Quebec Incorporated | Quebec | |
| Canada | Bluewater Clinical Research Group Incorporated | Sarnia | Ontario |
| Canada | Corcare Cardiovascular Research | Scarborough | Ontario |
| Canada | Heart Health Institute Research Incorporated | Scarborough | Ontario |
| Canada | Centre intégré de santé et de services sociaux (CISSS) des Laurentides - Unité de recherche clini | St Jerome | Quebec |
| Canada | SMH Cardiology Clinical Trials Incorporated | Surrey | British Columbia |
| Canada | North York Diagnostic and Cardiac Centre | Toronto | Ontario |
| Canada | Womens College Hospital | Toronto | Ontario |
| Canada | Dr T G Elliott Incorporated - BC Diabetes | Vancouver | British Columbia |
| Canada | Office of Dr Louis Yao | Weston | Ontario |
| Canada | Winnipeg Clinic | Winnipeg | Manitoba |
| Czechia | MUDr Igor Karen | Benatky nad Jizerou | |
| Czechia | Jessenia as, Nemocnice Beroun | Beroun | |
| Czechia | Medicentrum Beroun sro | Beroun | |
| Czechia | Medicus Services sro | Brandys nad Labem | |
| Czechia | Amkardia sro | Brno | |
| Czechia | CCR Brno sro | Brno | |
| Czechia | Centrum pro zdravi sro | Brno | |
| Czechia | Fakultni nemocnice Brno | Brno | |
| Czechia | Kardiologicka ambulance Brno sro | Brno | |
| Czechia | prof MUDr Lubomir Elbl, CSc, Kardiologicka ambulance | Brno | |
| Czechia | Vojenska nemocnice Brno | Brno | |
| Czechia | Edumed sro, Kardiologicka ambulance | Broumov | |
| Czechia | Cevni centrum Ceske Budejovice sro | Ceske Budejovice | |
| Czechia | Dika centrum sro | Havirov - Mesto | |
| Czechia | Clinical Trial Center Hodonin sro | Hodonin | |
| Czechia | Kardio Holesov sro | Holesov | |
| Czechia | MUDr Ladislava Harrerova, kardiologicka ordinace | Hradec Kralove | |
| Czechia | Karlovarska krajska nemocnice | Karlovy Vary | |
| Czechia | Oblastni nemocnice Kladno as | Kladno | |
| Czechia | Kardio Michal Cepelak sro | Klatovy IV | |
| Czechia | Oblastni nemocnice Kolin as | Kolin III | |
| Czechia | Krajska nemocnice Liberec as | Liberec | |
| Czechia | KardioBusak sro | Louny | |
| Czechia | Kardio Pudich s.r.o. | Ludgerovice | |
| Czechia | Vseobecna intermi ambulance sro | Milevsko | |
| Czechia | MUDr Zbynek Kosek, kardiologicka ambulance sro | Mlada Boleslav | |
| Czechia | Pozdisek sro, Kardiologicka ambulance | Mohelnice | |
| Czechia | CCR Ostrava sro | Ostrava | |
| Czechia | Mestska nemocnice Ostrava | Ostrava | |
| Czechia | Benedor sro - Kardiologicka, cevni a interni ambulance | Ostrava - Poruba | |
| Czechia | Kardiologicka a angiologicka ambulance | Ostrava-Dubina | |
| Czechia | Center for Clinical Research Pardubice, sro | Pardubice | |
| Czechia | Nemocnice Pardubickeho kraje as | Pardubice | |
| Czechia | Kardiologie v sadech sro | Plzen 1 | |
| Czechia | Diabet2 sro | Praha 1 | |
| Czechia | Ordinace pro choroby srdce a cev | Praha 10 | |
| Czechia | Kardiologie Cor sro | Praha 10 - Zabehlice | |
| Czechia | Vseobecna fakultni nemocnice v Praze | Praha 2 | |
| Czechia | CCR Prague sro | Praha 3 | |
| Czechia | Milan Kvapil sro | Praha 4 | |
| Czechia | Thomayerova nemocnice | Praha 4 | |
| Czechia | Fakultni nemocnice v Motole | Praha 5 | |
| Czechia | Interni a kardiologicka ordinace | Praha 5 | |
| Czechia | Kardiologicke centrum MUDr Janky Skrobakove sro | Praha 5 - Smichov | |
| Czechia | Endokrinologie Cerny Most sro | Praha 9 | |
| Czechia | Kardio Vaclavik sro, Interni a kardiologicka ambulance | Prerov | |
| Czechia | Vestra Clinics sro | Rychnov nad Kneznou | |
| Czechia | Nemocnice Pardubickeho kraje as, Svitavska nemocnice | Svitavy | |
| Czechia | AeskuLab ks, Lipidova poradna | Teplice | |
| Czechia | Nemocnice Podlesi as | Trinec | |
| Czechia | Clinical Trials Service sro | Uherske Hradiste | |
| Czechia | Interni ambulance | Uherske Hradiste | |
| Czechia | Lekarsky dum Ormiga | Zlin | |
| Czechia | KIGE sro | Znojmo | |
| Denmark | Aalborg Hospital | Aalborg | |
| Denmark | Center for Clinical and Basic Research Aalborg | Aalborg | |
| Denmark | Aarhus Universitetshospital | Aarhus N | |
| Denmark | Centre for Clinical and Basic Research Ballerup | Ballerup | |
| Denmark | Sydvestjysk Sygehus | Esbjerg | |
| Denmark | Sanos Clinic | Herlev | |
| Denmark | Steno Diabetes Center | Herlev | |
| Denmark | Regionhospitalet Herning | Herning | |
| Denmark | Hillerod Hospital | Hillerod | |
| Denmark | Rigshospitalet Kobenhavn | Kobenhavn O | |
| Denmark | Amager Hospital | Kobenhavn S | |
| Denmark | Kolding Sygehus | Kolding | |
| Denmark | Regionshospitalet Silkeborg | Silkeborg | |
| Denmark | Svendborg Sygehus | Svendborg | |
| Denmark | Center for Clinical and Basic Research Vejle | Vejle | |
| Denmark | Regionshospitalet Viborg | Viborg | |
| Estonia | Liina Viitas OU | Parnu | |
| Estonia | Center for Clinical and Basic Research Tallinn | Tallinn | |
| Estonia | Dr Arvo Rosenthal LLC | Tallinn | |
| Estonia | North Estonia Medical Centre Foundation | Tallinn | |
| Finland | GERI-MED Oy | Helsinki | |
| Finland | Helsinki University Central Hospital | Helsinki | |
| Finland | Pohjois-Karjalan keskussairaala | Joensuu | |
| Finland | Studycor Oy | Jyvaskyla | |
| Finland | Terveystalo Jyvaskyla | Jyvaskyla | |
| Finland | Satucon Oy/Kuopion tyoterveys | Kuopio | |
| Finland | University of Eastern Finland | Kuopio | |
| Finland | Oulu University Hospital | Oulu | |
| Finland | Oulu University Hospital | Oulu | |
| Finland | Tampere University Hospital | Tampere | |
| Finland | Terveystalo Pulssi | Turku | |
| France | Centre Hospitalier Universitaire Amiens - Hopital Sud | Amiens Cedex 1 | |
| France | Hospices Civils de Lyon Groupement Hospitalier Est, Hopital Louis Pradel | Bron | |
| France | Centre Hospitalier Universitaire de Caen - Hôpital Côte de Nacre | Caen Cedex 9 | |
| France | Centre Hospitalier Sud Francilien | Corbeil Essonnes | |
| France | Centre Hospitalier Universitaire de Dijon - Hopital Francois Mitterrand | Dijon | |
| France | Centre Hospitalier Universitaire de Grenoble - Hopital Nord Michallon | Grenoble | |
| France | Groupement Hospitalier Mutualiste | Grenoble | |
| France | Centre Hospitalier de Versailles - Hopital Andre Mignot | Le Chesnay | |
| France | Hopital Louis Pasteur | Le Coudray | |
| France | Centre Hospitalier Régional Universitaire de Lille - Institut Coeur Poumon | Lille | |
| France | Centre Hospitalier Universitaire de Lyon - Hopital Edouard Herriot | Lyon Cédex 3 | |
| France | Centre Hospitalier Universitaire de Marseille - Hôpital de la Timone | Marseille cedex 05 | |
| France | Hopital Saint-Joseph | Marseille Cedex 08 | |
| France | Centre Hospitalier Regional Universitaire de Montpellier - Hopital Arnaud de Villeneuve | Montpellier cedex 05 | |
| France | Centre Hospitalier Universitaire de Nantes - Hopital Guillaume et Rene Laennec | Nantes Cedex 1 | |
| France | Centre Hospitalier Universitaire de Nice - Hopital Pasteur | Nice Cedex 1 | |
| France | Centre Hospitalier Universitaire de Nimes | Nimes | |
| France | Hopital Bichat Claude Bernard | Paris | |
| France | Hopital Europeen Georges Pompidou | Paris | |
| France | Hopital Pitie-Salpetriere | Paris | |
| France | Hopital Saint Antoine | Paris | |
| France | Centre Hospitalier de Pau - Hopital Francois Mitterrand | Pau | |
| France | Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou | Rennes | |
| France | Clinique Saint Hilaire | Rouen | |
| France | Clinique Pasteur | Toulouse Cedex 3 | |
| France | Centre Hospitalier Universitaire de Toulouse - Hopital Rangueil | Toulouse Cedex 9 | |
| France | Polyclinique Vauban | Valenciennes | |
| Germany | Universitaets-Herzzentrum Freiburg - Bad Krozingen | Bad Krozingen | |
| Germany | Kerckhoff-Klinik Forschungs GmbH | Bad Neuheim | |
| Germany | Charite Universitätsmedizin Berlin, Charité Campus Virchow-Klinikum | Berlin | |
| Germany | Klinische Forschung Berlin GbR | Berlin | |
| Germany | Kardiologisch - Angiologische Praxis - Herzzentrum Bremen | Bremen | |
| Germany | Sankt-Johannes-Hospital | Dortmund | |
| Germany | Cardiologicum Dresden und Pirna | Dresden | |
| Germany | Diabetologische Gemeinschaftspraxis Dr Schaper und Dr Faulmann | Dresden | |
| Germany | Universitaetsklinikum Carl Gustav Carus, Medizinische Klinik und Poliklinik III | Dresden | |
| Germany | Clin Phenomics GmbH Co KG | Frankfurt am Main | |
| Germany | Klinikum und Fachbereich Medizin Johann Wolfgang Goethe-Universität Frankfurt am Main | Frankfurt am Main | |
| Germany | Medizinisches Versorgungszentrum im Altstadt-Carree Fulda | Fulda | |
| Germany | Cardiologicum Hamburg | Hamburg | |
| Germany | Universitätsklinikum Heidelberg | Heidelberg | |
| Germany | Ambulantes Herzzentrum Kassel | Kassel | |
| Germany | Universitätsklinikum Leipzig | Leipzig | |
| Germany | Otto von Guericke Universität Magdeburg | Magdeburg | |
| Germany | Johannes Gutenberg Universitaet Mainz | Mainz | |
| Germany | Universitätsklinikum Mannheim | Mannheim | |
| Germany | Praxis Doktor Jens Taggeselle | Markleeberg | |
| Germany | Deutsches Herzzentrum München des Freistaates Bayern | München | |
| Germany | Herz Gefaess Zentrum Nymphenburg | München | |
| Germany | Universitaetsklinikum Muenster | Münster | |
| Germany | Kardiologische Gemeinschaftspraxis Papenburg | Papenburg | |
| Germany | Klinikum Ernst von Bergmann gGmbH | Potsdam | |
| Germany | Universitätsklinikum Regensburg | Regensburg | |
| Germany | CardioConsil GmbH | Rostock | |
| Germany | I Medizinische Klinik Gesundheitsverbund Landkreis Konstanz | Singen | |
| Germany | Universitätsklinikum Ulm | Ulm | |
| Germany | Nephrologisches Zentrum Villingen-Schwenningen | Villingen-Schwenningen | |
| Germany | Forschungszentrum Ruhr | Witten | |
| Greece | Alexandra Hospital | Athens | |
| Greece | Athens Naval Hospital | Athens | |
| Greece | General Hospital of Athens Evaggelismos | Athens | |
| Greece | General Hospital of Athens Georgios Gennimatas | Athens | |
| Greece | General Hospital of Athens Ippokrateio | Athens | |
| Greece | General Hospital of Athens Laiko | Athens | |
| Greece | Hygeia Hospital | Athens | |
| Greece | Konstantopoulio - Agia Olga Hospital of Nea Ionia | Athens | |
| Greece | University Hospital of Heraklion | Heraklion | |
| Greece | University Hospital of Ioannina | Ioannina | |
| Greece | University Hospital of Larissa | Larissa | |
| Greece | Ahepa University Hospital | Thessaloniki | |
| Greece | General Hospital of Thessaloniki Ahepa | Thessaloniki | |
| Greece | Interbalkan Medical Center | Thessaloniki | |
| Greece | Papageorgiou General Hospital of Thessaloniki | Thessaloniki | |
| Hungary | Lausmed Kft | Baja | |
| Hungary | Allami Szivkorhaz Balatonfured | Balatonfured | |
| Hungary | Balatonmariafurdo Kozseg Onkormanyzatanak Haziorvosi Rendeloje | Balatonkeresztur | |
| Hungary | Med-Edu Bt | Balloszog | |
| Hungary | Dr Lakatos Ferenc Private Cardiology Practice | Bekescsaba | |
| Hungary | Grof Tisza Istvan Korhaz | Berettyoujfalu | |
| Hungary | Bajcsy-Zsilinszky Korhaz es Rendelointezet | Budapest | |
| Hungary | Betegapolo Irgalmas Rend - Budai Irgalmasrendi Korhaz | Budapest | |
| Hungary | Clinexpert Kft | Budapest | |
| Hungary | Gottsegen Gyorgy Orszagos Kardiologiai Intezet | Budapest | |
| Hungary | Jahn Ferenc Del-pesti Korhaz es Rendelointezet | Budapest | |
| Hungary | Magyar Honvedseg Egeszsegugyi Kozpont | Budapest | |
| Hungary | Obudai Egeszsegugyi Centrum Kft | Budapest | |
| Hungary | Semmelweis Egyetem | Budapest | |
| Hungary | Semmelweis Egyetem Varosmajori Sziv- es Ergyogyaszati Klinika | Budapest | |
| Hungary | Uzsoki Utcai Korhaz | Budapest | |
| Hungary | Zugloi Egeszsegugyi Szolgalat | Budapest | |
| Hungary | Debreceni Egyetem Klinikai Kozpont | Debrecen | |
| Hungary | Markhot Ferenc Oktatokorhaz es Rendelointezet | Eger | |
| Hungary | Erzsebet Gondozohaz | Godollo | |
| Hungary | Bugat Pal Korhaz | Gyongyos | |
| Hungary | Pharma4 Trial Kft | Gyongyos | |
| Hungary | Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaz | Gyula | |
| Hungary | BKS Research Kft | Hatvan | |
| Hungary | Bacs-Kiskun Megyei Korhaz Szegedi Tudomanyegyetem Altalanos Orvostudomanyi Kar Oktato Korhaza | Kalocsa | |
| Hungary | Selye Janos Korhaz | Komarom | |
| Hungary | Borsod-Abauj-Zemplen Megyei Kozponti Korhaz es Egyetemi Oktatokorhaz | Miskolc | |
| Hungary | CRU Hungary Kft | Miskolc | |
| Hungary | Pecsi Tudomanyegyetem Klinikai Kozpont | Pecs | |
| Hungary | Soproni Erzsebet Oktato Korhaz es Rehabilitacios Intezet | Sopron | |
| Hungary | Szegedi Tudomanyegyetem Szent Gyorgyi Albert Klinikai Kozpont Altalanos Orvostudomanyi Kar | Szeged | |
| Hungary | Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont Altalanos Orvostudomanyi Kar | Szeged | |
| Hungary | Praxispont Belvarosi Maganegeszsegugyi Kozpont | Szekesfehervar | |
| Hungary | Tolna Megyei Balassa Janos Korhaz | Szekszard | |
| Hungary | Csongrad Megyei Dr Bugyi Istvan Korhaz | Szentes | |
| Hungary | Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz-Rendelointezet | Szolnok | |
| Hungary | Belvarosi Egeszseghaz Kft | Zalaegerszeg | |
| Iceland | Hjartamidstodin | Kopavogur | |
| Iceland | Landspitali | Reykjavik | |
| Italy | Ospedale Muscatello | Augusta | |
| Italy | Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII | Bergamo | |
| Italy | Azienda Ospedaliero Universitaria di Bologna Policlinico S Orsola Malpighi | Bologna | |
| Italy | Azienda Ospedaliero Universitaria Mater Domini | Catanzaro | |
| Italy | Universita degli Studi Gabriele D Annunzio di Chieti e Pescara | Chieti | |
| Italy | Fondazione Toscana Gabriele Monasterio Ospedale del Cuore G Pasquinucci | Massa | |
| Italy | Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda | Milano | |
| Italy | Centro Cardiologico Monzino | Milano | |
| Italy | IRCCS Ospedale San Raffaele | Milano | |
| Italy | Azienda Ospedaliero Universitaria Pisana | Pisa | |
| Italy | Presidio Ospedaliero Santa Maria delle Grazie | Pozzuoli | |
| Italy | Azienda Ospedaliera Sant Andrea | Roma | |
| Italy | Policlinico Universitario Campus Biomedico | Roma | |
| Italy | IRCCS Policlinico San Donato | San Donato Milanese | |
| Italy | Azienda Ospedaliera Citta della Salute e della Scienza di Torino | Torino | |
| Italy | Azienda Ospedaliero Universitaria Integrata di Udine | Udine | |
| Korea, Republic of | Dong-A University Hospital | Busan | |
| Korea, Republic of | Inje University Busan Paik Hospital | Busan | |
| Korea, Republic of | Chungbuk National University Hospital | Cheongju-si, Chungcheongbuk-do | |
| Korea, Republic of | Keimyung University, Dongsan Hospital | Daegu | |
| Korea, Republic of | Yeungnam University Medical Center | Daegu | |
| Korea, Republic of | Chonnam National University Hospital | Gwangju | |
| Korea, Republic of | Gachon University Gil Medical Center | Incheon | |
| Korea, Republic of | Seoul National University Bundang Hospital | Seongnam-si, Gyeonggi-do | |
| Korea, Republic of | Asan Medical Center | Seoul | |
| Korea, Republic of | Gangnam Severance Hospital | Seoul | |
| Korea, Republic of | Kangbuk Samsung Hospital | Seoul | |
| Korea, Republic of | Korea University Anam Hospital | Seoul | |
| Korea, Republic of | Kyung Hee University Hospital | Seoul | |
| Korea, Republic of | Samsung Medical Center | Seoul | |
| Korea, Republic of | Seoul National University Hospital | Seoul | |
| Korea, Republic of | Severance Hospital, Yonsei University Health System | Seoul | |
| Korea, Republic of | The Catholic University of Korea Seoul St Marys Hospital | Seoul | |
| Korea, Republic of | Ajou University Hospital | Suwon-si, Gyeonggi-do | |
| Korea, Republic of | Yonsei University Wonju Severance Christian Hospital | Wonju-si, Gangwon-do | |
| Latvia | Daugavpils Regional Hospital | Daugavpils | |
| Latvia | Dace Teterovska Doctor Practice in Endocrinology | Ogre | |
| Latvia | Inga Jasinkevica Cardiologist Practice | Ogre | |
| Latvia | Outpatient Clinic Veselibas Centrs 4 | Riga | |
| Latvia | Pauls Stradins Clinical University Hospital | Riga | |
| Lithuania | Klinikiniai sprendimai, UAB | Alytus | |
| Lithuania | Hospital of Lithuanian University of Health Sciences Kaunas Clinics Public Institution | Kaunas | |
| Lithuania | Klinikiniai sprendimai, UAB | Kaunas | |
| Lithuania | Saules Seimos Medicinos Centras | Kaunas | |
| Lithuania | Kardiologijos ir reabilitacijos klinika, UAB | Klaipeda | |
| Lithuania | Siauliai Republican Hospital, Public Institution | Siauliai | |
| Lithuania | Vilnius University Hospital Santaros Clinic Public Institution | Vilnius | |
| Mexico | Centro de investigacion Cardiometabolica | Aguascalientes | |
| Mexico | Clinstile SA de CV | Cd De Mexico | Distrito Federal |
| Mexico | Scientia Investigacion Clinica Sc | Chihuahua | |
| Mexico | Centro para el Desarrollo de la Medicina y de Asistencia Medica Especializada SC | Culiacan | Sinaloa |
| Mexico | Unidad Biomedica Avanzada Monterrey | Monterrey | Nuevo León |
| Mexico | Centro de Estudios Clinicos de Queretaro | Queretaro | Querétaro |
| Netherlands | Noordwest Ziekenhuisgroep | Alkmaar | |
| Netherlands | Ziekenhuisgroep Twente | Almelo | |
| Netherlands | Emotional Brain | Almere | |
| Netherlands | Meander Medisch Centrum | Amersfoort | |
| Netherlands | Academisch Medisch Centrum | Amsterdam | |
| Netherlands | Onze Lieve Vrouwe Gasthuis | Amsterdam | |
| Netherlands | Onze Lieve Vrouwe Gasthuis | Amsterdam | |
| Netherlands | Gelre Ziekenhuis | Apeldoorn | |
| Netherlands | Rijnstate Ziekenhuis | Arnhem | |
| Netherlands | Rode Kruis Ziekenhuis | Beverwijk | |
| Netherlands | Amphia ziekenhuis | Breda | |
| Netherlands | Reinier de Graaf Gasthuis | Delft | |
| Netherlands | Huisartsenpraktijk Rambharose | Den Haag | |
| Netherlands | Deventer Ziekenhuis | Deventer | |
| Netherlands | Van Weel Bethesda Ziekenhuis | Dirksland | |
| Netherlands | Albert Schweitzer Ziekenhuis location Dordwijk | Dordrecht | |
| Netherlands | Albert Schweitzer Ziekenhuis, Locatie Dordwijk | Dordrecht | |
| Netherlands | Ziekenhuis Gelderse Vallei | Ede | |
| Netherlands | Catharina Ziekenhuis | Eindhoven | |
| Netherlands | Treant Zorggroep, locatie Scheper ziekenhuis Emmen | Emmen | |
| Netherlands | Medisch Spectrum Twente | Enschede | |
| Netherlands | Admiraal de Ruyter Ziekenhuis | Goes | |
| Netherlands | Groene Hart Ziekenhuis | Gouda | |
| Netherlands | Martini Ziekenhuis | Groningen | |
| Netherlands | Sint Jansdal Ziekenhuis | Harderwijk | |
| Netherlands | Zuyderland Medisch Centrum | Heerlen | |
| Netherlands | Elkerliek Ziekenhuis | Helmond | |
| Netherlands | Tergooi | Hilversum | |
| Netherlands | Bethesda Diabetes Research Center | Hoogeveen | |
| Netherlands | Dijklander Ziekenhuis Hoorn | Hoorn | |
| Netherlands | Medisch Centrum Leeuwarden | Leeuwarden | |
| Netherlands | Leids Universitair Medisch Centrum | Leiden | |
| Netherlands | Isala Diaconessenhuis | Meppel | |
| Netherlands | Sint Antonius Ziekenhuis, locatie Nieuwegein | Nieuwegein | |
| Netherlands | Canisius-Wilhelmina Ziekenhuis | Nijmegen | |
| Netherlands | Radboudumc | Nijmegen | |
| Netherlands | Franciscus Gasthuis | Rotterdam | |
| Netherlands | Ikazia Ziekenhuis | Rotterdam | |
| Netherlands | Maasstad Ziekenhuis | Rotterdam | |
| Netherlands | Praktijk Soerland | Rotterdam | |
| Netherlands | Franciscus Vlietland | Schiedam | |
| Netherlands | D&A Research and Genetics | Sneek | |
| Netherlands | Haga Ziekenhuis | The Hague | |
| Netherlands | Ziekenhuis Rivierenland | Tiel | |
| Netherlands | Elisabeth-Tweesteden Ziekenhuis | Tilburg | |
| Netherlands | Ziekenhuis Bernhoven | Uden | |
| Netherlands | Diakonessenhuis | Utrecht | |
| Netherlands | Universitair Medisch Centrum Utrecht | Utrecht | |
| Netherlands | VieCuri Medisch Centrum | Venlo | |
| Netherlands | Zaans Medisch Centrum | Zaandam | |
| Netherlands | Albert Schweitzer Ziekenhuis | Zwijndrecht | |
| Netherlands | Dokters van Nederhoven | Zwijndrecht | |
| Netherlands | Isala Klinieken | Zwolle | |
| Poland | Szpital Uniwersytecki nr 1 im dr Antoniego Jurasza w Bydgoszczy | Bydgoszcz | |
| Poland | American Heart of Poland Sa Malopolskie Centrum Sercowo-Naczyniowe PAKS - Chrzanow | Chrzanow | |
| Poland | Copernicus Podmiot Leczniczy Sp zoo | Gdansk | |
| Poland | Uniwersyteckie Centrum Kliniczne | Gdansk | |
| Poland | Marek Piepiorka Gabinet Kardiologiczno-Internistyczny | Gdynia | |
| Poland | NZOZ Srodmiescie Spzoo | Gdynia | |
| Poland | Spolka Cywilna Medicina | Gizycko | |
| Poland | Samodzielny Publiczny Specjalistyczny Szpital Zachodni im swietego Jana Pawla II | Grodzisk Mazowiecki | |
| Poland | Biokinetica SA | Jozefow | |
| Poland | Centrum Medyczne Pratia Katowice | Katowice | |
| Poland | Specjalistyczna Poradnia Kardiologiczna i Nadcisnienia Tetniczego Beata Wozakowska-Kaplon | Kielce | |
| Poland | Wojewodzki Szpital Zespolony w Kielcach | Kielce | |
| Poland | CARINTART Sp zoo Krakowskie Centrum Diagnostyczno-Kliniczne | Krakow | |
| Poland | Ewa Mirek-Bryniarska Specjalistyczna Praktyka Lekarska | Krakow | |
| Poland | Krakowskie Centrum Medyczne Spzoo | Krakow | |
| Poland | Zespol Przychodni Specjalistycznych Diab-End-Cor Sp z oo | Krakow | |
| Poland | Intercard Spzoo Centrum Kardiologii Inwazyjnej Elektroterapii i Angiologii w Krosnie | Krosno | |
| Poland | Samodzielny Publiczny Zaklad Opieki Zdrowotnej w Lecznej | Leczna | |
| Poland | Instytut Centrum Zdrowia Matki Polki | Lodz | |
| Poland | Wojewodzki Specjalistyczny Szpital im dr Wladyslawa Bieganskiego w Lodzi | Lodz | |
| Poland | Miedziowe Centrum Zdrowia Spolka Akcyjna | Lubin | |
| Poland | CenterMed Lublin Spzoo | Lublin | |
| Poland | Clinical Best Solutions Sp zoo Spolka komandytowa Gabinet Lekarski | Lublin | |
| Poland | Ko-med Centra Kliniczne Lublin II | Lublin | |
| Poland | NZOZ Twoja Przychodnia Spzoo | Lublin | |
| Poland | Szpital Swietej Anny w Miechowie | Miechow | |
| Poland | Podhalanski Szpital Specjalistyczny im Jana Pawla II w Nowym Targu | Nowy Targ | |
| Poland | Centrum Medyczne Pulawska spzoo Centrum Medyczne Pulawska NZOZ | Piaseczno | |
| Poland | NZOZ Specjalistyczna Przychodnia Lekarska Medikard | Plock | |
| Poland | Clinical Research Center Spzoo Medic-R Spolka Komandytowa | Poznan | |
| Poland | KO-MED Centra Kliniczne Spzoo KO-MED Centra Kliniczne Pulawy | Pulawy | |
| Poland | NZOZ Przychodnia Specjalistyczna Andrzej Wittek Henryk Rudzki spolka jawna | Ruda Slaska | |
| Poland | Clinical Best Solutions Spolka z ograniczona odpowiedzialnoscia Spolka komandytowa | Siedlce | |
| Poland | ETG Network Spzoo | Skierniewice | |
| Poland | KO-MED Centra Kliniczne Spzoo KO-MED Centra Kliniczne Staszow | Staszow | |
| Poland | Tomasz Blicharski Lubelskie Centrum Diagnostyczne | Swidnik | |
| Poland | Indywidualna Specjalistyczna Praktyka Lekarska | Szczecin | |
| Poland | Centrum Szybkiej Diagnostyki Kardiologicznej Kardiomed M Zabowka E Zabowka Spolka cywilna | Tarnow | |
| Poland | Medical Trials Institute Spzoo | Torun | |
| Poland | Prywatne Centrum Kardiologii | Torun | |
| Poland | Wojewodzki Szpital Zespolony im Ludwika Rydygiera w Toruniu | Torun | |
| Poland | Centrum Medyczne Amed Warszawa Zoliborz | Warszawa | |
| Poland | Centrum Medyczne Pratia Warszawa | Warszawa | |
| Poland | Clinical Best Solutions Sp zoo Spolka komandytowa | Warszawa | |
| Poland | Instytut Psychiatrii i Neurologii | Warszawa | |
| Poland | Szpital Grochowski imienia Doktora medycyny Rafala Masztaka Spzoo | Warszawa | |
| Poland | Samodzielny Publiczny Zaklad Opieki Zdrowotnej w Wegrowie | Wegrow | |
| Poland | Medicor Plus Kardiolodzy Spzoo | Wloclawek | |
| Poland | Centrum Badan Klinicznych Piotr Napora Lekarze Spolka Partnerska | Wroclaw | |
| Poland | Centrum Kardiologiczne Pro Corde Spzoo Centrum Kardiologicne Pro Corde Wroclaw | Wroclaw | |
| Poland | Futuremeds spolka z ograniczona odpowiedzialnoscia | Wroclaw | |
| Poland | KO-MED Centra Kliniczne Spzoo KO-MED Centra Kliniczne Zamosc | Zamosc | |
| Portugal | Hospital Garcia de Orta, EPE | Almada | |
| Portugal | Centro Hospitalar do Baixo Vouga, EPE - Hospital Infante Dom Pedro | Aveiro | |
| Portugal | Centro Hospitalar de Lisboa Ocidental, EPE - Hospital de Santa Cruz | Carnaxide | |
| Portugal | Centro Hospitalar e Universitario de Coimbra EPE | Coimbra | |
| Portugal | Hospital de Faro, EPE | Faro | |
| Portugal | Hospital da Senhora da Oliveira, Guimaraes, EPE | Guimaraes | |
| Portugal | Associacao Protectora dos Diabeticos de Portugal | Lisboa | |
| Portugal | Unidade Local de Saude de Matosinhos - Hospital Pedro Hispano | Matosinhos | |
| Portugal | Hospital Casa de Saude Sao Mateus | Viseu | |
| Romania | SC Centrul Medical de Diagnostic si Tratament Ambulator Neomed S.R.L | Brasov | |
| Romania | Spitalul Universitar de Urgenta Bucuresti | Bucharest | |
| Romania | Institutul de Urgenta pentru Boli Cardiovasculare "Prof. Dr. C. C. Iliescu", | Bucuresti | |
| Romania | Spitalul Clinic Universitar de Urgenta Elias | Bucuresti | |
| Romania | Cardiomed SRL | Craiova | |
| Romania | Consultmed SRL | Iasi | |
| Romania | SC Cardiomed SRL | Iasi | |
| Romania | SC Endodigest SRL | Oradea | |
| Romania | SC Sal Med SRL | Pitesti | |
| Romania | CMI Dr Podoleanu Cristian | Targu Mures | |
| Romania | Mediab SRL | Targu Mures | |
| Russian Federation | First City Clinical Hospital na E E Volosevich | Arkhangelsk | |
| Russian Federation | NSHI Departmental Hospital at the station Barnaul of OJSC Russian Railways | Barnaul | |
| Russian Federation | Regional State Budget Health care Institution Altay Regional Cardiology Dispensary | Barnaul | |
| Russian Federation | Central City Clinical Hospital 1 of the Oktyabrsky District | Ekaterinburg | |
| Russian Federation | State Budget Medical Institution Sverdlovsk Regional Clinical Hospital N1 | Ekaterinburg | |
| Russian Federation | Regional Budget Healthcare Institution Cardiology Dispensary | Ivanovo | |
| Russian Federation | BHI of Republic Udmurtiya City clinical hospital 9 of Ministry of healthcare of Republic Udmurtiya | Izhevsk | |
| Russian Federation | FSBI Heart and Vessels Diseases complex problems Scientific Research Institution | Kemerovo | |
| Russian Federation | Kirov Regional State Budget Healthcare Institution Kirov City Clinical Hospital 1 | Kirov | |
| Russian Federation | Regional Clinical Hospital 2 of the Ministry of Health Krasnodar region | Krasnodar | |
| Russian Federation | SBHI Scientific Research Institute Regional Clinical Hospital 1 named after S V Ochapovsky | Krasnodar | |
| Russian Federation | City Clinical Hospital named after Zhadkevich | Moscow | |
| Russian Federation | FSBI Russian Cardiology Research and Production Complex | Moscow | |
| Russian Federation | Moscow SBHI City Clinical Hospital 15 n a O M Filatov of Moscow Healthcare Department | Moscow | |
| Russian Federation | National Medical Research Center for therapy and preventive medicine | Moscow | |
| Russian Federation | SBHI of Moscow City clinical hospital 64 of Moscow Healthcare department | Moscow | |
| Russian Federation | SBHI of Nizhny Novgorod region Nizhny Novgorod regional clinical hospital na N A Semashko | Nizhny Novgorod | |
| Russian Federation | FSBSI Scientific Research Institute of Therapy and preventive medicine | Novosibirsk | |
| Russian Federation | LLC RC Medical | Novosibirsk | |
| Russian Federation | SBHI of Novosibirsk Region City clinical hospital 1 | Novosibirsk | |
| Russian Federation | Budget Healthcare Institution of Omsk region Medical-sanitary unit 9 | Omsk | |
| Russian Federation | Perm Regional Hospital for War Veterans | Perm | |
| Russian Federation | State Budget Institution of Ryazan Region Regional Clinical Hospital | Ryazan | |
| Russian Federation | Almazov National Medical Research Centre | Saint Petersburg | |
| Russian Federation | SBHI Medical and sports dispensary of Krasnogvardeisky district of Saint Petersburg | Saint Petersburg | |
| Russian Federation | City polyclinic 25 Nevsky district | Saint-Petersburg | |
| Russian Federation | LLC Mart | Saint-Petersburg | |
| Russian Federation | Saint Petersburg SBHI City Hospital 38 named after N A Semashko | Saint-Petersburg | |
| Russian Federation | Saint Petersburg State Budget Healthcare Institution City Polyclinic 109 | Saint-Petersburg | |
| Russian Federation | Saint Petersburg State Budget Healthcare Institution City Polyclinic 109 | Saint-Petersburg | |
| Russian Federation | Saint Petersburg State Budget Healthcare Institution Pokrovskaya City Hospital | Saint-Petersburg | |
| Russian Federation | LLC Medinef Clinic | Sait-Petersburg | |
| Russian Federation | Samara Regional Clinical Cardiology Dispensary | Samara | |
| Russian Federation | Clinical Hospital named after S R Mirotvortsev | Saratov | |
| Russian Federation | Regional State Budget Helthcare Institution Smolensk Regional Clinical Hospital | Smolensk | |
| Russian Federation | State Budgetary Health Institution City Hospital 4 of the City of Sochi | Sochi | |
| Russian Federation | City Polyclinic 27 | St. Petersburg | |
| Russian Federation | FSBSI Tomsk National Research Medical Center of the Russian Academy of Sciences | Tomsk | |
| Russian Federation | State Autonomous Healthcare Institution of the Tyumen region Medical Scientific Practical Center | Tyumen | |
| Russian Federation | Tyumen State Medical University | Tyumen | |
| Russian Federation | SBHI of Vladimirskaya region City Hospital 4 of Vladimir | Vladimir | |
| Russian Federation | Family Medicine Clinic | Volgograd | |
| Slovakia | Alian, sro | Bardejov | |
| Slovakia | MediTask, sro | Bratislava | |
| Slovakia | Narodny ustav srdcovych a cievnych chorob, as | Bratislava | |
| Slovakia | Veria, sro | Bratislava | |
| Slovakia | Nemocnica s poliklinikou Brezno, no | Brezno | |
| Slovakia | Cardio D and R, sro Kosice | Kosice | |
| Slovakia | Medical group Kosice sro | Kosice | |
| Slovakia | Kardio 1 sro | Lucenec | |
| Slovakia | Medi M and M sro | Moldava nad Bodvou | |
| Slovakia | Oralek, sro | Namestovo | |
| Slovakia | Kardiocentrum Nitra sro | Nitra | |
| Slovakia | Kardiomed NZ, sro | Nove Zamky | |
| Slovakia | Medikard, sro | Presov | |
| Slovakia | Medispol, sro | Presov | |
| Slovakia | Diab sro | Roznava | |
| Slovakia | Mediluk sro | Snina | |
| Slovakia | Interna SK, sro | Svidnik | |
| Slovakia | Areteus sro | Trebisov | |
| Slovakia | CardiOr, sro | Trencin | |
| Spain | Complexo Hospitalario Universitario A Coruña | A Coruña | Galicia |
| Spain | Hospital Virgen del Mar | Almeria | Andalucía |
| Spain | Hospital Universitari Germans Trias i Pujol | Badalona | Cataluña |
| Spain | Equip Atencio Primaria Sardenya | Barcelona | Cataluña |
| Spain | Hospital Clinic i Provincial de Barcelona | Barcelona | Cataluña |
| Spain | Hospital Universitario Reina Sofia | Cordoba | Andalucía |
| Spain | Hospital Universitario Virgen de la Arrixaca | El Palmar | Murcia |
| Spain | Hospital Universitario Virgen de las Nieves | Granada | Andalucía |
| Spain | Hospital Universitario de Gran Canaria Doctor Negrin | Las Palmas De Gran Canarias | Canarias |
| Spain | Fundacion Jimenez Diaz | Madrid | |
| Spain | Hospital Clinico San Carlos | Madrid | |
| Spain | Hospital Universitario 12 de Octubre | Madrid | |
| Spain | Hospital Universitario de La Princesa | Madrid | |
| Spain | Hospital Universitario Infanta Sofia | Madrid | |
| Spain | Hospital Universitario La Paz | Madrid | |
| Spain | Hospital Clinico Universitario Virgen de la Victoria | Malaga | Andalucía |
| Spain | Complejo Hospitalario de Navarra | Pamplona | Navarra |
| Spain | Hospital Universitari Sant Joan de Reus | Reus | Cataluña |
| Spain | Hospital Clinico Universitario de Santiago | Santiago de Compostela | Galicia |
| Spain | Hospital Universitario Virgen Macarena | Sevilla | Andalucía |
| Spain | Hospital Clinico Universitario de Valencia | Valencia | Comunidad Valenciana |
| Spain | Hospital Universitari i Politecnic La Fe | Valencia | Comunidad Valenciana |
| Spain | Hospital Clinico Universitario de Valladolid | Valladolid | Castilla León |
| Spain | Hospital Alvaro Cunqueiro | Vigo | Galicia |
| Spain | Hospital Universitario Miguel Servet | Zaragoza | Aragón |
| Sweden | Sodra Alvsborgs sjukhus | Boras | |
| Sweden | Falu Lasarett | Falun | |
| Sweden | Carlanderska | Goteborg | |
| Sweden | Sahlgrenska Universitetssjukhus | Goteborg | |
| Sweden | Obackakliniken i Harnosand | Harnosand | |
| Sweden | PharmaSite Helsingborg | Helsingborg | |
| Sweden | Lanssjukhuset Ryhov | Jonkoping | |
| Sweden | Centralsjukhuset Karlstad | Karlstad | |
| Sweden | Skaraborgs sjukhus Lidkoping | Lidkoping | |
| Sweden | Clemenstorgets Hjartmottagning | Lund | |
| Sweden | PharmaSite Malmo | Malmo | |
| Sweden | Ostersunds sjukhus | Ostersund | |
| Sweden | Akardo MedSite | Stockholm | |
| Sweden | Norrlands Universitetssjukhus | Umea | |
| Sweden | Hallands sjukhus Varberg | Varberg | |
| Taiwan | Hualien Tzu Chi Hospital | Hualien | |
| Taiwan | Kaohsiung Chang Gung Memorial Hospital | Kaohsiung | |
| Taiwan | Kaohsiung Medical University Chung-Ho Memorial Hospital | Kaohsiung | |
| Taiwan | Mackay Memorial Hospital Tamsui Branch | New Taipei | |
| Taiwan | Chung Shan Medical University Hospital | Taichung | |
| Taiwan | Taichung Veterans General Hospital | Taichung | |
| Taiwan | National Cheng Kung University Hospital | Tainan | |
| Taiwan | National Taiwan University Hospital | Taipei | |
| Taiwan | Taipei Veterans General Hospital | Taipei | |
| Taiwan | Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation | Taoyuan | |
| Ukraine | Ivano-Frankivsk Regional Clinical Cardiology Center of Ivano-Frankivsk Regional Council | Ivano-Frankivsk | |
| Ukraine | Communal Healthcare Institution Kharkiv City Clinical Hospital No27 | Kharkiv | |
| Ukraine | Communal Noncommercial enterprise "City Hospital #8" of Kharkiv City Council | Kharkiv | |
| Ukraine | Medical and Sanitary Unit of Open Joint Stock Company Kharkiv Tractor Plant | Kharkiv | |
| Ukraine | Communal Noncommercial Institution Consultative and Diagnostic Center of Desnianskyi District of Kyi | Kyiv | |
| Ukraine | Kyiv City Clinical Emergency Medical Care Hospital | Kyiv | |
| Ukraine | Kyiv City Clinical Hospital 1 | Kyiv | |
| Ukraine | Medical Centre CONSILIUM Medical | Kyiv | |
| Ukraine | National Scientific Center "M.D. Strazhesko Institute of Cardiology" | Kyiv | |
| Ukraine | Oleksandrivska Clinical Hospital of Kyiv | Kyiv | |
| Ukraine | State Institution National Scientific Center Acad MD Strazhesko Institute of cardiology of NAMS Ukr | Kyiv | |
| Ukraine | State Institution National Scientific Center Acad Strazhesko Institute of Cardiology | Kyiv | |
| Ukraine | Zakarpattia Oblast Clinical Center of Cardiology and Cardio Surgery | Uzhgorod | |
| Ukraine | Vinnytsia M I Pyrogov Regional Clinical Hospital Vinnytsia M I Pyrogov National Medical University | Vinnytsia | |
| Ukraine | Private Small Enterprise, Medical Center Pulse | Vinnytsya | |
| Ukraine | Communal Non-commercial enterprise "City Hospital #6 "of Zaporizhzhia City Council | Zaporizhzhia | |
| United Kingdom | Aberdeen Royal Infirmary | Aberdeen | |
| United Kingdom | Barnsley Hospital | Barnsley | |
| United Kingdom | Royal United Hospital | Bath | |
| United Kingdom | Ormeau Health Centre | Belfast | |
| United Kingdom | Royal Victoria Hospital | Belfast | |
| United Kingdom | Ulster Hospital | Belfast | |
| United Kingdom | Bollington Medical Centre | Bollington | |
| United Kingdom | Royal Bournemouth Hospital | Bournemouth | |
| United Kingdom | West Walk Surgery | Bristol | |
| United Kingdom | University Hospitals of Derby and Burton NHS Foundation Trust | Burton upon Trent | |
| United Kingdom | Ashgate Medical Practice | Chesterfield | |
| United Kingdom | Cleveleys Group Practice | Cleveleys | |
| United Kingdom | Lakeside Healthcare | Corby | |
| United Kingdom | Medinova Northamptonshire Dedicated Research Site | Corby | |
| United Kingdom | MeDiNova Warwickshire Quality Research Site | Coventry | |
| United Kingdom | Pound Hill Medical Group | Crawley | |
| United Kingdom | Ninewells Hospital | Dundee | |
| United Kingdom | Glasgow Royal Infirmary | Glasgow | |
| United Kingdom | Hull Royal Infirmary | Hull | |
| United Kingdom | Highlands Clinical Research Facility, Raigmore Hospital | Inverness | |
| United Kingdom | Sherbourne Medical Centre | Leamington Spa | |
| United Kingdom | Royal Liverpool University Hospital | Liverpool | |
| United Kingdom | Barts Health NHS Trust | London | |
| United Kingdom | Guys Hospital | London | |
| United Kingdom | Royal Free London NHS Foundation Trust | London | |
| United Kingdom | Wythenshawe Hospital | Manchester | |
| United Kingdom | Medinova North London Dedicated Research Centre | Northwood | |
| United Kingdom | Nottingham City Hospital | Nottingham | |
| United Kingdom | George Eliot Hospital | Nuneaton | |
| United Kingdom | Medinova South London Dedicated Research Centre | Orpington | |
| United Kingdom | Mounts Bay Medical Hub | Penzance | |
| United Kingdom | The Health Centre Yaxley | Peterborough | |
| United Kingdom | The Adam Practice | Poole | |
| United Kingdom | Medinova East London Dedicated Research Centre | Romford | |
| United Kingdom | Ashfield Primary Care Centre | Sandbach | |
| United Kingdom | Scunthorpe General Hospital | Scunthorpe | |
| United Kingdom | Medinova Limited | Shipley | |
| United Kingdom | Eaton Socon Health Centre | St Neots | |
| United Kingdom | Lakeside Healthcare Stamford | Stamford | |
| United Kingdom | Lister Hospital | Stevenage | |
| United Kingdom | Singleton Hospital | Swansea | |
| United Kingdom | The Breckland Alliance | Thetford | |
| United Kingdom | Torbay Hospital | Torquay | |
| United Kingdom | Pinderfields Hospital | Wakefield | |
| United Kingdom | Sheepcot Medical Practice | Watford | |
| United Kingdom | Sandwell General Hospital | West Bromwich | |
| United Kingdom | Whitby Group Practice | Whitby | |
| United Kingdom | MeDiNova West London Quality Research Site | Wokingham | |
| United Kingdom | Worcestershire Royal Hospital | Worcester | |
| United Kingdom | Yeovil District Hospital | Yeovil | |
| United States | Alexandria Cardiology Clinic | Alexandria | Louisiana |
| United States | Northwest Heart Clinical Research LLC | Arlington Heights | Illinois |
| United States | Asheville Cardiology Associates | Asheville | North Carolina |
| United States | North Alabama Research Center LLC | Athens | Alabama |
| United States | Maryland Cardiovascular Specialists | Baltimore | Maryland |
| United States | Northern Light Eastern Maine Medical Center | Bangor | Maine |
| United States | Metropolitan Cardiovascular Consultants LLC | Beltsville | Maryland |
| United States | Cardiovascular Research Foundation of Southern California | Beverly Hills | California |
| United States | Westside Medical Associates of Los Angeles | Beverly Hills | California |
| United States | Southern Maine Health Care | Biddeford | Maine |
| United States | Cardiovascular Associates | Birmingham | Alabama |
| United States | Excel Medical Clinical Trials | Boca Raton | Florida |
| United States | Grace Research LLC | Bossier City | Louisiana |
| United States | Brigham and Womens Hospital | Boston | Massachusetts |
| United States | Bay Area Cardiology | Brandon | Florida |
| United States | Healthwise Medical Associates | Brooklyn | New York |
| United States | Capital Area Research LLC | Camp Hill | Pennsylvania |
| United States | Geisinger Holy Spirit | Camp Hill | Pennsylvania |
| United States | University of North Carolina at Chapel Hill | Chapel Hill | North Carolina |
| United States | Pharmacorp Clinical Trials Inc | Charleston | South Carolina |
| United States | Novant Health Heart and Vascular Institute | Charlotte | North Carolina |
| United States | Trinity Medical Western New York, PC | Cheektowaga | New York |
| United States | The Christ Hospital | Cincinnati | Ohio |
| United States | University Hospitals Cleveland Medical Center | Cleveland | Ohio |
| United States | Kootenai Heart Clinics, LLC | Coeur d'Alene | Idaho |
| United States | Optumcare Colorado Springs LLC | Colorado Springs | Colorado |
| United States | University of Colorado Memorial Health System | Colorado Springs | Colorado |
| United States | Saint Elizabeth Covington | Covington | Kentucky |
| United States | Nature Coast Clinical Research LLC | Crystal River | Florida |
| United States | Soltero Cardiovascular Research Center | Dallas | Texas |
| United States | Southwest Family Medicine Associates | Dallas | Texas |
| United States | Midwest Cardiovascular Research Foundation | Davenport | Iowa |
| United States | Cardiology Research Associates | Daytona Beach | Florida |
| United States | Daytona Heart Group | Daytona Beach | Florida |
| United States | Complete Health Research | DeLand | Florida |
| United States | Cohen Medical Associates PA | Delray Beach | Florida |
| United States | Doylestown Health Cardiology | Doylestown | Pennsylvania |
| United States | West Coast Research LLC | Dublin | California |
| United States | Saint Marys Medical Center | Duluth | Minnesota |
| United States | North Ohio Heart Center | Elyria | Ohio |
| United States | Horizon Research Group of Opelousas LLC | Eunice | Louisiana |
| United States | Deaconess Clinic | Evansville | Indiana |
| United States | Lillestol Research LLC | Fargo | North Dakota |
| United States | Alpine Research Organization | Farmington | Utah |
| United States | Ahmed Arif Medical Research Center LLC | Flint | Michigan |
| United States | Jellinger and Lerman MD PA dba The Center for Diabetes and Endocrine Care | Fort Lauderdale | Florida |
| United States | Piedmont Research Partners | Fort Mill | South Carolina |
| United States | Charles River Medical Associates | Framingham | Massachusetts |
| United States | New West Physicians | Golden | Colorado |
| United States | Healthy Heart Cardiology | Grand Rapids | Michigan |
| United States | East Mountain Medical Associates, PC | Great Barrington | Massachusetts |
| United States | Great Falls Clinic LLP | Great Falls | Montana |
| United States | George E Platt MD | Green Cove Springs | Florida |
| United States | Moses H Cone Memorial Hospital | Greensboro | North Carolina |
| United States | Tribe Clinical Research LLC DBA Mountain View Clinical Research | Greenville | South Carolina |
| United States | Louisiana Heart Center | Hammond | Louisiana |
| United States | Research Physicians Network Alliance | Hollywood | Florida |
| United States | Heart Center Research LLC | Huntsville | Alabama |
| United States | The University of Iowa College of Public Health | Iowa City | Iowa |
| United States | Rajendra H Mehta, MD, PC | Jackson | Michigan |
| United States | First Coast Cardiovascular Institute PA | Jacksonville | Florida |
| United States | Jacksonville Center for Clinical Research | Jacksonville | Florida |
| United States | University of Florida and Shands Hospital | Jacksonville | Florida |
| United States | Baptist Health Research Institute | Jacksonville Beach | Florida |
| United States | Lycoming Internal Medicine Inc | Jersey Shore | Pennsylvania |
| United States | NSC Research | Johns Creek | Georgia |
| United States | Kansas City Veterans Affairs Medical Center | Kansas City | Missouri |
| United States | The University of Kansas Medical Center | Kansas City | Kansas |
| United States | WMCHealth Heart and Vascular Institute Kingston Division of Cardiology | Kingston | New York |
| United States | Humble Cardiology Associates | Kingwood | Texas |
| United States | Texas Cardiology Associates of Houston | Kingwood | Texas |
| United States | Palm Research Center Inc | Las Vegas | Nevada |
| United States | The Research Group of Lexington LLC | Lexington | Kentucky |
| United States | Bryan Heart | Lincoln | Nebraska |
| United States | Main Street Physicians Care Waterway | Little River | South Carolina |
| United States | Arkansas Cardiology | Little Rock | Arkansas |
| United States | Central Arkansas Veterans Healthcare System | Little Rock | Arkansas |
| United States | South Denver Cardiology Associates | Littleton | Colorado |
| United States | Texas Institute for Kidney and Endocrine Disorders | Lufkin | Texas |
| United States | Northwell Health Physician Partners Cardiology | Manhasset | New York |
| United States | Sanjay Vora Research LLC | Marion | Ohio |
| United States | Texas Institute of Cardiology | McKinney | Texas |
| United States | Southern Endocrinology Associates PA | Mesquite | Texas |
| United States | Cardiovascular Research Center of South Florida | Miami | Florida |
| United States | Gad Research Center | Miami | Florida |
| United States | LaPorte County Institute for Clinical Research | Michigan City | Indiana |
| United States | Minneapolis Heart Institute Foundation | Minneapolis | Minnesota |
| United States | Mobile Heart Specialists PC | Mobile | Alabama |
| United States | Crossroads Clinical Research Inc | Mooresville | North Carolina |
| United States | The Diabetes Center | Murrells Inlet | South Carolina |
| United States | Barnum Medical Research | Natchitoches | Louisiana |
| United States | North Shore Diabetes and Endocrine Associates | New Hyde Park | New York |
| United States | Northwell Health Lenox Hill Heart and Vascular | New York | New York |
| United States | Intend Research | Norman | Oklahoma |
| United States | Parkway Cardiology Associates | Oak Ridge | Tennessee |
| United States | Ocala Research Institute, Inc | Ocala | Florida |
| United States | Permian Research Foundation | Odessa | Texas |
| United States | Nebraska Western Iowa Health Care System | Omaha | Nebraska |
| United States | Desert Oasis Healthcare Medical Group | Palm Springs | California |
| United States | Cardiology Consultants | Pensacola | Florida |
| United States | Cardiology Consultants of Philadelphia CCP | Philadelphia | Pennsylvania |
| United States | Perelman Center for Advanced Medicine | Philadelphia | Pennsylvania |
| United States | University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania |
| United States | Charlotte Heart Group Research Center | Port Charlotte | Florida |
| United States | Oregon Health and Science University | Portland | Oregon |
| United States | Hudson Valley Cardiovascular Physicians PC | Poughkeepsie | New York |
| United States | Miriam Hospital | Providence | Rhode Island |
| United States | Multicare Institute for Research and Innovation | Puyallup | Washington |
| United States | Monument Health Clinical Research | Rapid City | South Dakota |
| United States | Covigilant Research, LLC | Riverside | California |
| United States | Piedmont Medical Group Research of Rocky Mount | Rocky Mount | North Carolina |
| United States | Sierra Clinical Research | Roseville | California |
| United States | Center for Clinical Trials of Sacramento Inc | Sacramento | California |
| United States | Saint Cloud Hospital | Saint Cloud | Minnesota |
| United States | Mercy Research | Saint Louis | Missouri |
| United States | HealthEast Medical Research Institute | Saint Paul | Minnesota |
| United States | PMG Research of Salisbury | Salisbury | North Carolina |
| United States | TidalHealth Peninsula Regional, Inc | Salisbury | Maryland |
| United States | Mercury Medical Conversions LTD | San Antonio | Texas |
| United States | South Texas Cardiovascular Consultants PLLC | San Antonio | Texas |
| United States | North Ohio Heart Center-Sandusky | Sandusky | Ohio |
| United States | Cardiovascular Center of Sarasota | Sarasota | Florida |
| United States | Intercoastal Medical Group | Sarasota | Florida |
| United States | Saratoga Clinical Research, LLC | Saratoga Springs | New York |
| United States | Grace Research LLC | Shreveport | Louisiana |
| United States | Louisiana Heart Center | Slidell | Louisiana |
| United States | Division of Cardiovascular Research at Peconic Bay Medical Center | Southampton | New York |
| United States | Baystate Health Center | Springfield | Massachusetts |
| United States | Heart House Research Foundation | Springfield | Ohio |
| United States | Cardiology Associates of Fairfield County, PC | Stamford | Connecticut |
| United States | Suffolk Multispecialty Research LLC | Suffolk | Virginia |
| United States | Palmetto Clinical Research | Summerville | South Carolina |
| United States | Universal Research Group LLC | Tacoma | Washington |
| United States | Northwest Houston Heart Center | Tomball | Texas |
| United States | Harbor University of California Los Angeles Medical Center | Torrance | California |
| United States | Munson Medical Center | Traverse City | Michigan |
| United States | Oklahoma Heart Institute | Tulsa | Oklahoma |
| United States | Virtua Health, Inc. | Voorhees | New Jersey |
| United States | Aspirus Research Institute | Wausau | Wisconsin |
| United States | MercyOne Iowa Heart Center | West Des Moines | Iowa |
| United States | Selma Medical Associates | Winchester | Virginia |
| United States | Novant Health Forsyth Medical Center | Winston-Salem | North Carolina |
| United States | Wake Forest University Health Sciences | Winston-Salem | North Carolina |
| United States | Florida Cardiology Group | Winter Park | Florida |
| United States | The Florida Lipid Institute | Winter Park | Florida |
| Lead Sponsor | Collaborator |
|---|---|
| Amgen |
United States, Argentina, Australia, Austria, Belgium, Brazil, Bulgaria, Canada, Czechia, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Iceland, Italy, Korea, Republic of, Latvia, Lithuania, Mexico, Netherlands, Poland, Portugal, Romania, Russian Federation, Slovakia, Spain, Sweden, Taiwan, Ukraine, United Kingdom,
Bohula EA, Marston NA, Ruzza A, Murphy SA, De Ferrari GM, Diaz R, Leiter LA, Elliott-Davey M, Wang H, Bhatia AK, Giugliano RP, Sabatine MS. Rationale and design of the effect of evolocumab in patients at high cardiovascular risk without prior myocardial infarction or stroke (VESALIUS-CV) trial. Am Heart J. 2024 Mar;269:179-190. doi: 10.1016/j.ahj.2023.12.004. Epub 2023 Dec 29. — View Citation
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Time to Coronary Heart Disease Death, Myocardial Infarction, or Ischemic Stroke | Time to coronary heart disease (CHD) death, myocardial infarction (MI), or ischemic stroke, whichever occurs first. | From randomization; for approximately a median of 4.5 years | |
| Primary | Time to Coronary Heart Disease Death, Myocardial Infarction, Ischemic Stroke, or Any Ischemia-driven Arterial Sroke | Time to CHD death, MI, ischemic stroke, or any ischemia-driven arterial revascularization, whichever occurs first. | From randomization; for approximately a median of 4.5 years | |
| Secondary | Time to MI, Ischemic Stroke, or Any Ischemia-driven Arterial Revascularization | From randomization; for approximately a median of 4.5 years | ||
| Secondary | Time to CHD Death, MI, or Any Ischemia-driven Arterial Revascularization | From randomization; for approximately a median of 4.5 years | ||
| Secondary | Time to Cardiovascular Death, MI, or Ischemic Stroke | From randomization; for approximately a median of 4.5 years | ||
| Secondary | Time to CHD Death or MI | From randomization; for approximately a median of 4.5 years | ||
| Secondary | Time to Myocardial Infarction | From randomization; for approximately a median of 4.5 years | ||
| Secondary | Time to Any Ischemia-driven Arterial Revascularization | From randomization; for approximately a median of 4.5 years | ||
| Secondary | Time to CHD Death | From randomization; for approximately a median of 4.5 years | ||
| Secondary | Time to Cardiovascular Death | From randomization; for approximately a median of 4.5 years | ||
| Secondary | Time to All Cause of Death | From randomization; for approximately a median of 4.5 years | ||
| Secondary | Time to Ischemic Stroke | From randomization; for approximately a median of 4.5 years |
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Withdrawn |
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