Clinical Trial Details
— Status: Completed
Administrative data
| NCT number |
NCT04651101 |
| Other study ID # |
IR.SUMS.MED.REC.1398.246 |
| Secondary ID |
|
| Status |
Completed |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
March 1, 2019 |
| Est. completion date |
November 1, 2020 |
Study information
| Verified date |
December 2020 |
| Source |
Shiraz University of Medical Sciences |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
Large population cross sectional study, was conducted between 2018-2020 by attendance of 4526
patients in shiraz, Iran. Patients were undergone selective coronary angiography from radial
artery approach by an expert interventional cardiologist. 25-hydroxy vitamin D and Hs-CRP
levels were measured for all patients
Description:
This cross-sectional study was conducted in Shiraz. Clinical data were collected from the
patients of Professor Kojuri cardiovascular clinic in Shiraz, Iran ( Iran, Fars Province,
Shiraz, Niayesh Boulevard, Email: kojurij@yahoo.com, webpage: http://kojuriclinic.com/ )who
came to clinic from March 2018 to March 2020. Inclusion criteria was all of the new patients
who referred to Professor Kojuri cardiovascular clinic. Exclusion criteria were patients with
more than 100ng/ml 25-hydroxy vitamin D3 serum level, parathyroid disorders,
end-stage-renal-disease (ESRD) and paraneoplastic syndromes. Patients with more than 10mg/L
Hs-CRP serum level also were excluded.
Complete history and physical exam were taken from the patients and risk factors such as
hypertension, diabetes mellitus, age and gender were considered. 25-hydroxy vitamin D3 was
checked for all patients. Blood pressure and took electrocardiography (ECG) for all patients
were done. The dependent variable was the prevalence of Coronary Artery disease; the
independent variable was vitamin D deficiency; and intervening factors were age, gender,
hypertension, diabetes mellitus and level of Hs-CRP.
All Patients were undergone selective coronary angiography from radial artery approach by an
expert interventional cardiologist. Angiography videos were reviewed by a team of expert
cardiologists. Based on the results of coronary angiography, patients were classified as
non-significant CAD with stenosis less than 50% and significant CAD with stenosis more than
50% stenosis. In this review diabetic and hypertensive patients is considered by criteria of
American diabetes association 2018 & American heart association 2017 . Patient's serum level
of 25-hydroxy vitamin D on their first visit was considered as index of vitamin D level.
Vitamin D deficiency and sufficiency are defined respectively as serum level of 25-hydroxy
vitamin D less than 30ng/ml and serum level of 25-hydroxy vitamin D more than 30 ng/ml .
Patients with Parathyroid disorders and paraneoplastic syndromes were excluded
