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Role of Endothelial Function, Muscular Fitness and Metabolism in Functional Activity in Patients With Chronic Heart Failure (CHF)

Coronary Disease Clinical Trial

Official title:
Role of Endothelial Function, Muscular Fitness and Metabolism in Functional Activity in Patients With Chronic Heart Failure

Clinical Trial Summary

Shortness of breath, fatigue, and exercise intolerance are clinical symptoms of chronic heart failure (CHF). Recent studies suggested that peripheral impairment was the major cause of clinical symptoms, and mechanism may be related to neuroendocrine impairment and vascular smooth muscle dysfunction. It results in increased peripheral resistance that may influence limb blood flow, muscle fitness and activities of daily.The purposes of this study are

1. to compare muscular strength, endurance, and perfusion of quadriceps between CHF patients and healthy controls by isokinetic test and near-infrared spectroscopy (NIRS) and difference in activities of daily living

2. to compare endothelium function between CHF patients and healthy control subjects

3. the relationship between endothelium function, muscular strength, endurance, perfusion, and metabolism of quadriceps.

Clinical Trial Description

n/a

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01139086
Study type Observational
Source National Taiwan University Hospital
Contact Ying-Tai Wu, Ph.D
Phone +886-2-33668129
Email ytw@ntu.edu.tw
Status Recruiting
Phase N/A
Start date May 2010
Completion date May 2011
View Details
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