Myocardial Infarction Clinical Trial
Official title:
Controlled Trial of Serologic and Clinical Efficacy of Influenza Vaccine in Post-Myocardial Infarction Patients and in Those With Stable Angina Pectoris
This study wishes to understand:
1. whether vaccination against influenza in coronary artery disease (myocardial infarction
and stable angina) patients is as effective as it is in healthy subjects;
2. whether vaccination really decreases the episodes of influenza infection in those
coronary artery disease patients who receive the vaccine than those who do not.
Influenza infection may become complicated in patients with chronic conditions, including
coronary artery disease (CAD) [1]. Influenza vaccination is now recommended as part of
comprehensive secondary prevention in individuals with coronary and other atherosclerotic
vascular disease (evidence level: Class I, Level B) [2]. Although there is controversial
evidence pro [3,4] and against [5] the efficacy of influenza vaccination in protecting CAD
population against cardiovascular events, the efficacy of vaccine in actual reduction in
episodes of influenza infection and its fatal complications in CAD patients has not been, to
our knowledge, well studied before. Furthermore, we found no report comparing serologic
response to the influenza vaccine antigens between CAD patients and healthy controls.
This study aims to identify the efficacy of influenza vaccination in CAD individuals in
terms of both serologic response (as compared with healthy individuals) and clinical
outcomes (as compared with CAD patients not vaccinated).
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Prevention
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