Clinical Trials Logo
  1. Home
  2. Coronary Artery Disease
  3. NCT06372509
  4. Details
NCT06372509 Clinical Trial

A Proteomic Analysis for Understanding the Link Between Migraine and Cardiovascular Disease

Coronary Artery Disease Clinical Trial

— PMCD  

Official title:
A Proteomic Analysis for Understanding the Link Between Migraine and Cardiovascular Disease

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT06372509
Other study ID # L2-070
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date April 3, 2024
Est. completion date October 30, 2025

Study information
Verified date April 2024
Source Centro Cardiologico Monzino
Contact Daniela Trabattoni, MD
Phone 0258002780
Email daniela.trabattoni@cardiologicomonzino.it
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

This is a multicenter, prospective observational study. Will be collecting data from 90 consecutive patients (aged 25- 60 years ) with and without migraine admitted at our Hospital. Primary aim of the study will be to assess the correlation between migraine and proteomic profiling of plasma and their possible correlation with known cardio and cerebrovascular disease and Cardiovascular (CV) risk factors.

Description:

Ninety consecutive patients hospitalized for noncoronary artery disease will follow their clinical course. They will be classified into symptomatic for migraine with aura (N=45) and migraine free (N=45) and will be enrolled in the study. Patients will be screened for migraine characteristics and a comprehensive clinical analysis, including sex-related cardiovascular risk factors, will be collected. To achieve the study objective, blood will be drawn to do targeted proteomic evaluation of proteins relevant to Cardiovascular disease (CVD), inflammation, immune response, and neurological disorders, in order to compare the profile of migraine patients with that obtained in patients without migraine.

Recruitment information / eligibility
Status Recruiting
Enrollment 90
Est. completion date October 30, 2025
Est. primary completion date October 30, 2025
Accepts healthy volunteers
Gender All
Age group 25 Years to 60 Years
Eligibility Inclusion Criteria: - Age >25 years and > 60 years - Signed patient informed consent form (ICF) - Non-coronary disease Exclusion Criteria: - Age < 25 years and > 60 years - Acute myocardial infarction (MI) - Chronic kidney disease: glomerular filtration rate (GFR) < 30 ml/min - Severe mitral or aortic valvular disease - Acute heart failure - Reduced left ventricular (LV) function (Ejection Fraction < 35%) - Atrial Fibrillation

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Italy Centro Cardiologico Monzino Milano Milan

Sponsors (2)
Lead Sponsor Collaborator
Centro Cardiologico Monzino IRCCS Policlinico S. Donato

Country where clinical trial is conducted

Italy, 

Outcome
Type Measure Description Time frame Safety issue
Primary Correlation between migraine and proteomic profiling of plasma A blood sample will be obtained to perform a targeted proteomic assessment of proteins relevant in CVD, inflammation, immune response and neurological disorders in order to compare migraineurs patients profile with the one obtained in migraine-free patients October 2025
See also
  Status Clinical Trial Phase
Recruiting NCT06030596 - SPECT Myocardial Blood Flow Quantification for Diagnosis of Ischemic Heart Disease Determined by Fraction Flow Reserve
Completed NCT04080700 - Korean Prospective Registry for Evaluating the Safety and Efficacy of Distal Radial Approach (KODRA)
Recruiting NCT03810599 - Patient-reported Outcomes in the Bergen Early Cardiac Rehabilitation Study N/A
Recruiting NCT06002932 - Comparison of PROVISIONal 1-stent Strategy With DEB Versus Planned 2-stent Strategy in Coronary Bifurcation Lesions. N/A
Not yet recruiting NCT06032572 - Evaluation of the Safety and Effectiveness of the VRS100 System in PCI (ESSENCE) N/A
Recruiting NCT05308719 - Nasal Oxygen Therapy After Cardiac Surgery N/A
Recruiting NCT04242134 - Drug-coating Balloon Angioplasties for True Coronary Bifurcation Lesions N/A
Completed NCT04556994 - Phase 1 Cardiac Rehabilitation With and Without Lower Limb Paddling Effects in Post CABG Patients. N/A
Recruiting NCT05846893 - Drug-Coated Balloon vs. Drug-Eluting Stent for Clinical Outcomes in Patients With Large Coronary Artery Disease N/A
Recruiting NCT06027788 - CTSN Embolic Protection Trial N/A
Recruiting NCT05023629 - STunning After Balloon Occlusion N/A
Completed NCT04941560 - Assessing the Association Between Multi-dimension Facial Characteristics and Coronary Artery Diseases
Completed NCT04006288 - Switching From DAPT to Dual Pathway Inhibition With Low-dose Rivaroxaban in Adjunct to Aspirin in Patients With Coronary Artery Disease Phase 4
Completed NCT01860274 - Meshed Vein Graft Patency Trial - VEST N/A
Recruiting NCT06174090 - The Effect of Video Education on Pain, Anxiety and Knowledge Levels of Coronary Bypass Graft Surgery Patients N/A
Completed NCT03968809 - Role of Cardioflux in Predicting Coronary Artery Disease (CAD) Outcomes
Terminated NCT03959072 - Cardiac Cath Lab Staff Radiation Exposure
Recruiting NCT05065073 - Iso-Osmolar vs. Low-Osmolar Contrast Agents for Optical Coherence Tomography Phase 4
Recruiting NCT04566497 - Assessment of Adverse Outcome in Asymptomatic Patients With Prior Coronary Revascularization Who Have a Systematic Stress Testing Strategy Or a Non-testing Strategy During Long-term Follow-up. N/A
Completed NCT05096442 - Compare the Safety and Efficacy of Genoss® DCB and SeQuent® Please NEO in Korean Patients With Coronary De Novo Lesions N/A