Coronary Artery Disease Clinical Trial
Official title:
Association of Postoperative Lactate Levels With Postoperative Atrial Fibrillation in Patients Undergoing Isolated Coronary Artery Bypass Graft Surgery
Postoperative atrial fibrillation (POAF) is associated with increased mortality and morbidity in patients undergoing isolated coronary artery bypass grafting (CABG). It has been estimated that 5-40% of CABG patients experience POAF. Advanced age, P wave abnormalities, left atrial dilation, emergency surgery, low left ventricle ejection fraction, low glomerular filtration rate and chronic obstructive pulmonary disease have been reported in the etiology. Predicting which patients would experience POAF following CABG is important since it would allow physicians to apply more focused prophylactic measures. Lactate is the final product of anaerobic glycolysis. Serum lactate level are increased in case of inadequate oxygen delivery to tissues. The investigators aim to assess whether serum lactate levels measured early in the postoperative period could be used as a predictive marker of POAF in adults undergoing isolated CABG.
| Status | Recruiting |
| Enrollment | 250 |
| Est. completion date | September 15, 2023 |
| Est. primary completion date | August 15, 2023 |
| Accepts healthy volunteers | |
| Gender | All |
| Age group | 18 Years and older |
| Eligibility | Inclusion Criteria: - Undergoing isolated CABG - Age >18 years Exclusion Criteria: - Age <18 years - Pregnancy - History of paroxysmal atrial fibrillation prior to surgery - Undergoing concomitant procedures (e.g., CABG + valve surgery) - Any preoperative cardiac rhythm other than normal sinus rhythm - More than mild cardiac valve stenosis or insufficiency |
| Country | Name | City | State |
|---|---|---|---|
| Turkey | Basaksehir Cam Sakura City Hospital | Istanbul |
| Lead Sponsor | Collaborator |
|---|---|
| Basaksehir Cam & Sakura Sehir Hospital |
Turkey,
Dobrev D, Aguilar M, Heijman J, Guichard JB, Nattel S. Postoperative atrial fibrillation: mechanisms, manifestations and management. Nat Rev Cardiol. 2019 Jul;16(7):417-436. doi: 10.1038/s41569-019-0166-5. Review. — View Citation
Greenberg JW, Lancaster TS, Schuessler RB, Melby SJ. Postoperative atrial fibrillation following cardiac surgery: a persistent complication. Eur J Cardiothorac Surg. 2017 Oct 1;52(4):665-672. doi: 10.1093/ejcts/ezx039. Review. — View Citation
O'Connor E, Fraser JF. The interpretation of perioperative lactate abnormalities in patients undergoing cardiac surgery. Anaesth Intensive Care. 2012 Jul;40(4):598-603. Review. — View Citation
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Postoperative atrial fibrillation | New-onset atrial fibrillation occurring in the immediate period after CABG | 30 days |
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