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Coronary Artery Disease (CAD) clinical trials

View clinical trials related to Coronary Artery Disease (CAD).

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NCT ID: NCT02873052 Completed - Atherosclerosis Clinical Trials

MyoVista Measurements in Patients With Atherosclerosis and CAD

Start date: September 1, 2015
Phase:
Study type: Observational

The MyoVista system is a novel electrocardiogram technology that provides nonā€invasive assessment of myocardial abnormalities by analyzing energy changes at the cellular level of the myocardium.

NCT ID: NCT02765568 Completed - Clinical trials for Coronary Artery Disease (CAD)

Investigating the Effects of Cardiac Rehabilitation eXercise Modalities on Physical and Mental Health Outcomes

CRX-Modalities
Start date: June 2016
Phase: N/A
Study type: Interventional

Coronary revascularization improves survival for patients with coronary artery disease. However,many patients are left with poor physical and mental health. Traditional cardiac rehabilitation involves moderate intensity continuous exercise (MICE). Alternatives to traditional cardiac rehabilitation programming may however provide superior understudied benefits to patients with poor physical and mental health. Nordic walking (NW) and high-intensity interval training (HIIT) are two examples of alternative programs for cardiac rehabilitation, which may provide superior physical and mental health benefits when compared to traditional MICE. The main purpose of this project is, therefore, to determine the short and long term physical and mental health benefits of alternative cardiac rehabilitation modalities, including NW and HIIT on exercise capacity, quality of life and depression after a 12-week program.

NCT ID: NCT02629575 Completed - Clinical trials for Coronary Artery Disease (CAD)

Coroflex ISAR 2000 Registry

ISAR2000
Start date: January 2014
Phase: N/A
Study type: Observational [Patient Registry]

Postmarket surveillance in terms of the safety and efficacy of Sirolimus-eluting Coroflex ISAR Stent for the treatment of "real world" patients with de-novo and restenotic lesions after stand-alone angioplasty in coronary arteries

NCT ID: NCT02624297 Recruiting - Clinical trials for Coronary Artery Disease (CAD)

Chemoreflex Control of Sympathetic Activity in Patients With Coronary Artery Disease

Start date: January 2014
Phase: N/A
Study type: Interventional

The investigators hypothesize that chemoreflex response of muscle sympathetic nerve activity (MSNA) during hypoxia and hypercapnia will be increased in coronary artery disease (CAD) patients and that the presence of obstructive sleep apnea (OSA) will potentiate these responses. And, that the exercise training would decrease the chemoreflex response of MSNA in these patients.

NCT ID: NCT02554292 Completed - Clinical trials for Coronary Artery Disease (CAD)

Post Market Surveillance of SeQuent Please Neo With Scoring Balloon

PASSWORD
Start date: October 2015
Phase:
Study type: Observational [Patient Registry]

The main objective of the SeQuent® Please Neo post market surveillance is to assess the clinical suitability of the combination of pre-dilatation using the NSE Alpha scoring balloon before the use of the paclitaxel-coated SeQuent® Please Neo in an 'all comer'/ 'real world' setting for the treatment of in-stent restenosis and de-novo lesions.

NCT ID: NCT02341664 Completed - Stroke Clinical Trials

Patient and Provider Assessment of Lipid Management Registry

PALM
Start date: May 2015
Phase:
Study type: Observational [Patient Registry]

The purpose of the Patient and Provider Assessment of Lipid Management Registry (PALM) is to gain a better understanding of physicians' cholesterol medication prescribing practices, patient and physician attitudes and beliefs related to cholesterol management, and current utilization of cholesterol-lowering therapies given the new ACC/AHA guideline recommendations. The PALM Registry hopes to allow for the design of ways to improve cholesterol management and decrease the burden of cardiovascular disease (CVD) in the US.

NCT ID: NCT02098772 Completed - Clinical trials for Aortic Valve Disease

Phase III Study Comparing Two Methods of Cardioplegia in Aortic Valve Surgery Custodiol-N Versus Custodiol

Custodiol-AV
Start date: May 2014
Phase: Phase 3
Study type: Interventional

The objective of this investigation is to compare the cardioprotective effects and safety of two cardioplegic solutions, HTK Cardioplegic Solution (Custodiol) and Custodiol-N in patients undergoing aortic valve surgery. The study design is a prospective, double blind, multicenter, randomized, Phase III comparison study intended to demonstrate superiority in surgical outcome between Custodiol and Custodiol-N as determined by CK-MB peak value 4-24 hours after opening of the aortic cross-clamp (primary endpoint), catecholamine requirement (cumulative dose) and cardiac Troponin T, occurrence of comorbid events postoperatively (e.g., myocardial infarction).

NCT ID: NCT02083146 Terminated - Clinical trials for Coronary Artery Disease (CAD)

C1q/TNF-related Proteins in Coronary Artery Disease

Start date: March 2011
Phase:
Study type: Observational

Now, adipose tissue is established as an active endocrine organ that controls systemic energy homeostasis by secretion of adipokines. Recently, members of the C1q/tumor necrosis factor-related protein (CTRP) family have been reported to share structural homology with adiponectin. To date, 15 CTRP family members have been found that might play major roles in metabolism and inflammation. The investigators tried to clarify the relationship between CTRP family and coronary artery disease (CAD) in Korean men and women.

NCT ID: NCT01991093 Completed - Clinical trials for Coronary Artery Disease (CAD)

Multiple Electrode Aggregometry & Clopidogrel Resistance

Start date: June 2014
Phase:
Study type: Observational

Antiplatelet therapy with aspirin-clopidogrel reduces the risk of cardiovascular episodes after percutaneous coronary intervention (PCI) in patients with acute coronary syndromes. However, a significant number of patients experience recurrent events while on such therapy. The individual response to dual antiplatelet therapy is not uniform, and consistent findings across multiple investigations support the association between a lower degree of platelet inhibition, high on-treatment platelet reactivity, and the occurrence of atherothrombotic events [1, 2]. Particularly in diabetic patients, clopidogrel resistance is more prevalent compared with non-diabetics [3,4], which seems to contribute to the increased atherothrombotic risk in these patients compared with those without diabetes mellitus (DM) [5]. A number of platelet function instruments have now become available that are simple to use and can be utilized as point-of-care (POC) instruments in order to monitor antiplatelet therapy and potentially assess the risk of a recurrent event [6].

NCT ID: NCT01979445 Completed - Clinical trials for Coronary Artery Disease (CAD)

Cangrelor to Clopidogrel or Prasugrel Transition Study

BRIDGE
Start date: December 2, 2013
Phase: Phase 2
Study type: Interventional

There are two separate objectives in this study: 1. To demonstrate the pharmacodynamic (PD) profile when participants treated with cangrelor are switched to oral prasugrel 60 mg administered 30 minutes (min) after cangrelor infusion is discontinued 2. To demonstrate the PD profile when participants treated with cangrelor are switched to oral clopidogrel 600 mg administered during or immediately after cangrelor infusion.