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Coronary Artery Bypass clinical trials

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NCT ID: NCT01285271 Completed - Coronary Disease Clinical Trials

A Pre- and Post- Coronary Artery Bypass Graft Implantation Disposed Application of Xenon

CArDiAX
Start date: May 2011
Phase: Phase 3
Study type: Interventional

The aim of this study is to determine whether xenon - as compared to sevoflurane - can be applied safely in patients for general anesthesia before and after CABG implantation.

NCT ID: NCT01256372 Completed - Cardiac Surgery Clinical Trials

An Trial of Two Dosing Regimens of AP214 for the Prevention of Kidney Injury in Patients Undergoing Cardiac Surgery

Start date: October 2010
Phase: Phase 2
Study type: Interventional

This study investigates the effect of two dose-levels of AP214 on the prevention of (acute) kidney injury after cardiac surgery.

NCT ID: NCT01213511 Completed - Clinical trials for Coronary Artery Bypass

Neurocognitive Outcome After Coronary Artery Bypass Surgery Using Minimal Versus Conventional Extracorporeal Circulation

Start date: January 2009
Phase: N/A
Study type: Interventional

The aim of this study is to assess the effect of minimal (MECC) versus conventional (CECC) extracorporeal circulation on neurocognitive function after elective coronary bypass grafting (CABG) as well as whether this can be attributed to improved cerebral perfusion intraoperatively.

NCT ID: NCT01185600 Completed - Clinical trials for Coronary Artery Bypass

Microparticles in Stored RBC as Potential Mediators of Transfusion Complications

Start date: July 2010
Phase: N/A
Study type: Interventional

INTRODUCTION. Cell-derived microparticles (MP) are released in cell activation, apoptosis and other processes. MP derived from red cells (RMP) are known to be released from stored packed red blood cells (PRBC), and their number increases with storage time. This constitutes one aspect of the storage lesion. Adverse transfusion events are known to increase with time of PRBC storage. The explanation for this is not known. HYPOTHESIS. Based on their findings and those of others, the investigators propose to test the hypothesis that MP in stored PRBC contribute to adverse effects of transfusion. Specifically, MP in stored blood: (1) increase procoagulant activity, expression of pro-inflammatory mediators, immune suppression, and endothelial disturbance; and (2) increase the risk of transfusion and post-operative complications in patients undergoing coronary artery bypass grafting (CABG). AIMS & PROCEDURES. The aim of this study is to assess the clinical significance of MPs in PRBC-related transfusion complications utilizing washed PRBC. Packed red blood cells (PRBC) will be washed at the blood bank to obtain MP depleted PRBC (PRBC-MP). A total of 500 patients undergoing CABG will be initially randomized to 2 groups: one to receive PRBC-MP, and the other conventional PRBC (PRBC+MP). Using a panel of lab tests/biomarkers selected for high sensitivity the investigators will compare the 2 groups with respect to subclinical physiologic host responses including (i) endothelial disturbances, (ii) inflammatory, and (iii) procoagulant responses. In addition, clinically evident transfusion complications and short term (<=30 days) surgical complications will be assessed and compared. Patients who are randomized but end up not requiring transfusion at surgery will serve as controls. Laboratory and clinical results will also be evaluated to elucidate which tests are significantly associated with clinically adverse effects. SIGNIFICANCE. This study will shed new light on the biochemical and clinical effects of transfusion of MP. The findings of this investigation could significantly improve transfusion practice and safety.

NCT ID: NCT01118468 Recruiting - Clinical trials for Coronary Artery Bypass

Systematic Assessment of Competitive Flow in Coronary Artery Bypass Grafts by Wave Intensity Analysis

Start date: January 2010
Phase: N/A
Study type: Observational

Narrowing of the arteries that supply blood to the heart can lead to heart attacks and death. One way of treating this is to use artery and vein grafts from other parts of the body to bypass the narrowing. However, the blood flow from these grafts "competes" with flow through the natural coronary artery. This may contribute to grafts narrowing with time. This protocol aims to determine the pressure changes responsible for this effect. This could improve our understanding of why some grafts last longer than others.

NCT ID: NCT01033916 Completed - Coronary Disease Clinical Trials

Strict or Liberal Insulin Protocol Following Coronary Artery Bypass Graft (CABG) Surgery

SLIP
Start date: December 1, 2009
Phase: N/A
Study type: Interventional

This research study is designed to better understand post-operative complications as related to the tightness of blood sugar control. It is also hoped that we may learn that a more liberal control of your blood sugars is not inferior to the current strict glucose control. Our ultimate goal is to evaluate if there is any change in the rates of complications between the two groups. We will be comparing the current strict blood glucose control with a more liberal target for blood sugars.

NCT ID: NCT00911976 Completed - Atherosclerosis Clinical Trials

Study of the Xience V Everolimus-eluting Stent in Saphenous Vein Graft Lesions

SOS-Xience V
Start date: May 2009
Phase: Phase 4
Study type: Interventional

The specific aim of the SOS-Xience V study is to examine the 12-month incidence of binary angiographic in-stent restenosis after implantation of the Xience V stent in aortocoronary saphenous vein bypass graft lesions.

NCT ID: NCT00872001 Terminated - Stroke Clinical Trials

The Effect Of Acadesine On Reducing Cardiovascular and Cerebrovascular Adverse Events In Coronary Artery Bypass Graft (CABG) Surgery (Study P05633 AM1)(TERMINATED)

RED-CABG
Start date: April 2009
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether acadesine is effective in reducing the cardiovascular and cerebrovascular adverse events in high-risk participants undergoing CABG surgery.

NCT ID: NCT00823082 Completed - Clinical trials for Coronary Artery Bypass

Use of Antithrombin in Cardiac Surgery With Cardiopulmonary Bypass

Start date: May 2009
Phase: Phase 2
Study type: Interventional

The purpose of this trial is to study the effects of preoperative antithrombin supplementation in patients undergoing cardiac surgery with cardiopulmonary bypass in order to maintain antithrombin levels in a range greater than 58% and, eventually, to decrease negative clinical outcomes during the ICU stay.

NCT ID: NCT00707044 Completed - Clinical trials for Coronary Artery Bypass

Short-Stay Intensive Care for Coronary Artery Bypass Patients

Start date: January 2001
Phase: Phase 3
Study type: Interventional

Objective: To evaluate the safety and cost-effectiveness of Short Stay Intensive Care (SSIC) treatment for low-risk coronary artery bypass patients Design: Randomized clinical equivalence trial Setting: University Hospital Maastricht, the Netherlands Patients: low-risk coronary artery bypass patients Interventions: 600 patients were randomly assigned to undergo either SSIC treatment (8 hours Intensive Care) or control treatment (care as usual, overnight Intensive Care). Measurements: The primary outcome measures were Intensive Care (IC) readmissions and total hospital stay. The secondary outcome measures were total hospital costs, Quality of Life (QoL), postoperative morbidity and mortality. Hospital costs consisted of the cost of hospital admission(s) and outpatient costs.