Coronary Arteriosclerosis Clinical Trial
Official title:
Effects of Exercise Training on Left Ventricular Function in Type 2 Diabetic Patients Post Coronary Artery Bypass Graft
The purpose of this study is to investigate the changes of cardiorespiratory fitness and
left ventricular function in type 2 diabetes after uncomplicated coronary artery bypass
graft (CABG) surgery.
We hypothesize that exercise capacity, left ventricular diastolic function, and biochemical
data improves after 12-wk exercise training in patients with type 2 diabetes underwent CABG.
Patients with type 2 diabetes mellitus have higher incidence of coronary artery disease or
left ventricular dysfunction, particularly diastolic dysfunction. Coronary artery bypass
surgery is known to decrease the mortality rate in diabetes. Further exercise training can
improve their cardiorespiratory fitness and the control of risk factors in these patients.
However, the extent of improvement and the mechanism, especially the changes in left
ventricular function, in diabetes after exercise training have not been fully explored.
Subjects will be assigned to the intervention or control group by randomization. Subjects in
the intervention group will receive 60% VO2 max moderate aerobic exercise training, twice
per week under supervision and three times per week at home, for 12 weeks. All subjects
receive left ventricular function test by echocardiography and impedance cardiography,
graded maximal exercise test, and biochemical analyses of sugar and lipid before and after
12 weeks. Their dietary intake and physical activity will be inquired every 4 weeks by
questionnaires.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Investigator, Outcomes Assessor)
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