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Contraception clinical trials

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NCT ID: NCT04731818 Completed - Contraception Clinical Trials

An Exploratory Study of ZB-06 as a Vaginal Contraceptive Film

Start date: January 27, 2021
Phase: Early Phase 1
Study type: Interventional

This is an early Phase 1 study to establish proof-of-concept by determining whether an intravaginal film containing a human contraceptive antibody (ZB-06) shows promise to provide contraceptive efficacy using the post-coital test, a surrogate measure of efficacy. The study will also evaluate the safety and pharmacokinetics of ZB-06.

NCT ID: NCT04725643 Active, not recruiting - Contraception Clinical Trials

Keep Contraceptive Arm Long Acting-iMplant (CALM) and Carry On

CALM
Start date: February 17, 2022
Phase:
Study type: Observational

The investigators will conduct an observational study comparing the number of bleeding days before and after contraceptive implant (Nexplanon) replacement.

NCT ID: NCT04717596 Completed - Contraception Clinical Trials

Implementation and Examination of Contraception Care for Hospitalized Adolescents With Mental Health Disorders

Start date: April 7, 2021
Phase:
Study type: Observational

This study is a hybrid trial that examines both the clinical effectiveness and the implementation of BC4Teens Contraception Care. The investigators use a naturalistic one-group longitudinal study design to maximize feasibility and external validity, which is important for understanding implementation and effectiveness in real-world service delivery settings.

NCT ID: NCT04682353 Completed - Contraception Clinical Trials

A Study to Evaluate the Pharmacokinetics (PK) of Medroxyprogesterone Acetate Following an Injection of TV-46046 in Healthy Women of Reproductive Age

Start date: December 14, 2020
Phase: Phase 1
Study type: Interventional

The primary objective of this study is to evaluate and compare the pharmacokinetic profile of Medroxyprogesterone acetate following subcutaneous administration of 3 different doses of TV-46046 and a dose of Depo-subQ Provera in healthy female participants. The secondary objectives of the study are to evaluate and compare the safety, local tolerability, and acceptability of a subcutaneous injection of 3 different doses of TV-46046 and a dose of Depo-subQ Provera in healthy female participants. The total duration of the study for each participant is expected to be up to 19.5 months.

NCT ID: NCT04678817 Active, not recruiting - Contraception Clinical Trials

Same Day Oral EC and Implant Initiation

Start date: January 15, 2021
Phase:
Study type: Observational

This is a study for clients presenting for emergency contraception (EC). EC is used to prevent pregnancy after unprotected intercourse. Clients presenting for EC may be offered either the copper or hormonal IUD or oral EC. Current guidelines allow for same-day implant initiation at the time of an EC encounter, as long as oral LNG EC is co-administered. This study will look at pregnancy rates and clients willingness to receive same-day implant + oral EC and same-day IUDs.

NCT ID: NCT04676061 Terminated - Contraception Clinical Trials

Effects of a Progestin on Frequent and/or Prolonged Bleeding With Nexplanon™

Start date: February 11, 2021
Phase: Phase 4
Study type: Interventional

Effects of norethindrone acetate (NTA) in patients with Nexplanon.

NCT ID: NCT04669678 Active, not recruiting - HIV Infections Clinical Trials

Evaluation of Pharmacokinetic Drug-drug Interactions Between Hormonal Contraceptives and Doravirine-containing ART Among Women Living With HIV in South Africa

EPIC
Start date: November 17, 2021
Phase: Phase 4
Study type: Interventional

The study investigators are conducting an observational, parallel group pharmacokinetic (PK) study among women living with HIV (WLHIV) already on 1st line antiretroviral therapy (ART) and virally suppressed, 18-45 years old (inclusive), to evaluate any bidirectional drug-drug interactions (DDIs) between doravirine (DOR)-containing ART and hormonal contraceptive methods. This PK study will enroll women in five distinct groups, each with 21 participants (total of 105 participants), and follow them for approximately 18-30 weeks.

NCT ID: NCT04666792 Recruiting - HIV Infections Clinical Trials

PrEParing Family Planning Clinics to Streamline Integration of HIV Prevention Services for Young Women in Kenya

Start date: March 1, 2021
Phase: Phase 4
Study type: Interventional

This a prospective, open-label implementation project to catalyze integration of HIV prevention and PrEP care services for adolescent girls and young women in family planning clinics in Kenya.

NCT ID: NCT04627805 Terminated - Contraception Clinical Trials

Evaluating MyPath to Enhance Reproductive Autonomy and Liberate Decision-making

EMERALD
Start date: November 20, 2020
Phase: N/A
Study type: Interventional

This is a pilot study to evaluate the acceptability and feasibility of incorporating a patient-facing reproductive decision support tool, MyPath, into existing clinical pathways in a SUD treatment program. This study will be conducted virtually in partnership with a single substance use treatment program within the University of Pittsburgh Medical Center (UPMC). Aim 1: Assess the feasibility and acceptability of incorporating a patient-facing reproductive decision support tool (MyPath) into existing clinical pathways in a substance use treatment program. Aim 2: Assess preliminary efficacy of MyPath on reproductive health knowledge, self-efficacy, and decisional conflict as compared to usual care, as well comparisons between receipt of reproductive health services during the usual care period versus after implementing the intervention. The investigators hypothesize that the MyPath tool is acceptable and feasible for participants and their providers within a SUD treatment program. They also anticipate that preliminary efficacy data will show a positive correlation between the MyPath intervention and receipt of reproductive services, as well as increased knowledge and self-efficacy with decreased decision conflict. This pilot study will lay the groundwork for future larger trials in order to measure efficacy of this tool in substance use treatment settings.

NCT ID: NCT04626596 Active, not recruiting - Contraception Clinical Trials

A Study to Assess Contraceptive Efficacy and Safety of Etonogestrel (ENG) Implant Beyond 3 Years of Use (MK-8415-060)

Start date: November 19, 2020
Phase: Phase 3
Study type: Interventional

The primary purpose of this study is to assess the efficacy and safety of the etonogestrel (ENG) contraceptive implant during participants' fourth and fifth years of use when used as the only method of contraception. The ENG implant is currently approved for a 3-year duration, and this study aims to confirm available evidence suggesting that the ENG implant remains highly effective when used up to 5 years.