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Conscious Sedation clinical trials

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NCT ID: NCT01805726 Completed - Bronchoscopy Clinical Trials

Sedation During Bronchoscopy:Dexmedetomidine vs Alfentanil

Start date: February 2013
Phase: Phase 3
Study type: Interventional

The purpose of this study is to find the best sedation necessary for patients undergoing bronchoscopy. Patients are randomized to three different regimes of sedation during bronchoscopy were studied: 1. - Group standard/control: local anesthesia only(C) 2. - Group alfentanil + local anesthesia(A) 3. - Group dexmedetomidine + local anesthesia(D) The primary endpoint is the bronchoscopy score. Secondary endpoints are: Level of sedation and tolerance bronchoscopy examination. Measured parameters on the safety of examination are: the lowest saturation, needs to supplemental oxygen, amnesia , choking sensation or chest pain and if the patient is ready or not to undertake bronchoscopy second time in his life if necessary. Endtidal CO2, Respiratory rate, Blood pressure, Heart rate, level of oxygen are collected every 5 minutes before, during and after the bronchoscopy.

NCT ID: NCT01778608 Completed - Conscious Sedation Clinical Trials

Feasability Test of a Handset Device to Detect Levels of Sedation and Loss of Consciousness

Start date: January 2012
Phase:
Study type: Observational

Sedation is often administered to relieve anxiety and discomfort during uncomfortable procedures in elderly patients. Patient control of sedation offers many potential benefits for patients and healthcare professionals, including improved safety and patient satisfaction. The investigators overall goal is to develop a patient controlled intravenous sedation system that is effective but very safe for the patient, and requires minimal supervision by a doctor or nurse. To fulfill these criteria, a sedation system should incorporate fail-safe safety mechanisms. A key safety-critical component is a method of objectively assessing the degree of sedation of the patient, and of preventing him from self-administering unsafe doses of the sedative drug. The investigators have designed a new sedation system that uses a measure of the speed of response of the patient to a defined non-noxious stimulus to determine whether or not it is safe to allow him to self-administer further levels of sedation. Before being able to execute a volunteer study in order to determine a rational selection of optimal threshold response time, a feasibility test on the handset device is required.

NCT ID: NCT01143766 Completed - Conscious Sedation Clinical Trials

Gabapentin to Improve Patient Tolerance in Endoscopic Retrograde Cholangiopancreatography (ERCP)

Start date: April 2010
Phase: N/A
Study type: Interventional

The standard approach to sedation in endoscopic retrograde cholangiopancreatography (ERCP) involves the use of benzodiazepines and opiates to achieve a moderate depth of sedation. There is data to suggest supplementing this regimen with gabapentin may lead to reduced pain, higher patient satisfaction and lower opiate requirements. The investigators are conducting a clinical trial to study this hypothesis.

NCT ID: NCT01081002 Completed - Conscious Sedation Clinical Trials

Propofol Sedation During Upper Endoscopy With and Without Topical Pharyngeal Anesthesia

Start date: August 2009
Phase: Phase 4
Study type: Interventional

It is unclear whether a topical pharyngeal anesthesia adds any benefit to the upper gastrointestinal endoscopy under a propofol sedation. We hypothesize that a topical pharyngeal anesthesia does not ease the upper gastrointestinal endoscopy under propofol sedation. The aim of this study is therefore to quantify the impact of a topical pharyngeal anesthesia to the upper gastrointestinal endoscopy in patients sedated with propofol. Patients will be randomized to receive a topical pharyngeal spray containing either an anesthetic drug (lidocaine 10%) or a placebo. Thereafter the upper endoscopy will be conducted in its standard manner.

NCT ID: NCT01020643 Completed - Conscious Sedation Clinical Trials

Closed-loop Sedation of Propofol for Patients Undergoing Spinal Anesthesia

Start date: November 2009
Phase: Phase 4
Study type: Interventional

The purpose of this study is to compare the administration of a standard anesthetic drug (propofol) using an automatic, expert-based system versus a manually controlled system by the anesthesiologist. In addition, the performance of the decision support system will be evaluated.

NCT ID: NCT00959062 Completed - Critical Illness Clinical Trials

Adjunctive Clonidine in the Sedation of Mechanically Ventilated Children

NAPS Pilot
Start date: January 2010
Phase: Phase 4
Study type: Interventional

Almost all critically ill children who are mechanically ventilated require sedation and analgesia. Providing effective sedation for children in the PICU requires careful balancing of the need for sedation with the adverse effects associated with sedative medications. Clonidine is often used as an adjunctive sedative and analgesic in children but a well designed and adequately powered randomized trial is required to test the effect of clonidine-based sedation. Because there are no large randomized trials of sedation related interventions among critically ill children there are many unknown factors. This pilot trial, focussing on feasibility outcomes will assess the feasibility of, and inform the design of, a larger randomized controlled trial which will focus on clinically important outcomes.

NCT ID: NCT00834470 Completed - Conscious Sedation Clinical Trials

Adjunctive Atropine During Ketamine Sedation

Start date: August 2008
Phase: Phase 4
Study type: Interventional

- Ketamine seems an obvious choice in the setting of an emergency department - Ketamine leads to increased production of salivary and tracheal secretions - Antisialagogues(atropine)therefore have been recommended as a routine adjunct - We compare atropine with placebo as an adjunct to ketamine sedation in children undergoing primary closure of lacerated wound

NCT ID: NCT00665119 Completed - Clinical trials for Respiratory Insufficiency

Effects of Remifentanil on Respiratory Function in Mechanically Ventilated Patients

Start date: April 2008
Phase: Phase 4
Study type: Interventional

Sedation is widely used in mechanically ventilated patients. Propofol, benzodiazepines and opioids are the most used drugs. The study hypothesis is that sedation with remifentanil (an opioid drug) could improved respiratory pattern and effort in mechanically ventilated patients with rapid shallow breathing or high respiratory rate.

NCT ID: NCT00641563 Completed - Critical Care Clinical Trials

Effects of Two Different Sedation Regimes on Auditory Evoked Potentials and Electroencephalogram (EEG)

Start date: March 2004
Phase: N/A
Study type: Interventional

Sedation may be necessary in intensive care to facilitate diverse therapeutic interventions, but the use of sedative drugs may increase the risk of delirium and long-term cognitive impairment. Thus the implementation and monitoring of sedation remains difficult despite the use of sedation protocols and clinical sedation scores. Attempts to improve sedation monitoring through the use of the electroencephalogram(EEG) have been disappointing. Derived variables based on the unstimulated EEG fail to predict the response to external stimuli at the clinically most relevant light-to-moderate sedation levels, and the overlap between moderate and deep sedation levels is wide. We have demonstrated that long-latency auditory evoked potentials (ERPs)can be used to avoid deep levels of sedation in healthy volunteers during propofol sedation, independent of the concomitant administration of remifentanil. This approach has a potential clinical application for improved monitoring of sedation. Since the effects of different sedative drugs on the EEG may vary widely, the use of ERPs to monitor sedation needs to be evaluated with different sedative drugs. Therefore we will administer two widely used drug combinations (dexmedetomidine/remifentanil and midazolam/remifentanil) in healthy volunteers and record ERPS and processed EEG during clinical relevant sedation levels

NCT ID: NCT00452426 Completed - Colonoscopy Clinical Trials

Safety and Effectiveness of a Computer-Assisted Personalized Sedation (CAPS) Device for Propofol Delivery During Endoscopy

Start date: March 2007
Phase: Phase 3
Study type: Interventional

Patients routinely receive sedation during a colonoscopy or upper endoscopy (esophagogastroduodenoscopy; EGD) procedure. Propofol is a sedative that can be used during these procedures. The purpose of this study is to determine if this CAPS device enables a physician/registered nurse (RN) team to safely and effectively administer propofol sedation during colonoscopy or EGD procedures relative to current sedation practices.