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Conscious Sedation clinical trials

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NCT ID: NCT03886454 Completed - Bronchoscopy Clinical Trials

Incidence and Nature of Respiratory Impairment in Consecutive Patients Undergoing Bronchoscopy Under Conscious Sedation: A Pilot Study

Start date: June 19, 2017
Phase:
Study type: Observational

This study aims to characterize airflow patterns during bronchoscopy under conscious sedation, and determine the incidence of obstructive and central respiratory events. The investigators also plan to monitor the degree and frequency of oxygen desaturation throughout the procedure. To achieve this, investigators use a physiologic monitoring device (NOX T3, K082113) that has been FDA approved for the screening and diagnosis of sleep disordered breathing [1]. The results from this pilot study will be used to assess the feasibility of a prospective study utilizing continuous external negative pressure (Pneuway). This negative pressure is applied through a neck mask to alleviate upper airway collapsibility and can potentially decrease the number of apneas during bronchoscopy under conscious sedation [2].

NCT ID: NCT03885427 Completed - Clinical trials for Postoperative Analgesia

Analgo-Sedative Effects Of Oral, Or Nebulized Ketamine In Pre-schoolers Undergoing Elective Surgery.

Start date: March 27, 2019
Phase: Early Phase 1
Study type: Interventional

the primary objective of this study is to investigate the sedative, and analgesic effects of oral, or nebulized ketamine as premedication drugs, and providing postoperative analgesia for the preschoolers and decrease their need for systemic analgesia.The secondary objective is to compare each sedation technique after oral, or nebulized ketamine for safety ,and procedural outcomes.

NCT ID: NCT03735368 Completed - Conscious Sedation Clinical Trials

Dexmedetomidine and Pregabalin for Conscious Sedation During Cataract Surgery

Start date: December 10, 2018
Phase: Phase 2
Study type: Interventional

Although topical anesthesia by eye drops for cataract surgery is a non-invasive technique but it may provide insufficient anesthesia which requires the intraoperative use of additional topical local anesthetics and raises the need for sedation.

NCT ID: NCT03548493 Completed - Conscious Sedation Clinical Trials

Magnesium Sulphate Versus Fentanyl for Conscious Sedation in CSDH

CSDH
Start date: April 10, 2018
Phase: Phase 2
Study type: Interventional

The investigators hypothesize that magnesium sulphate owing to its analgesic and sedative properties is not inferior to fentanyl in providing conscious sedation as adjuvants to propofol and local injection of lidocaine in patients undergoing surgery for evacuation of subdural haematoma. Consequently, the investigators are testing this hypothesis by comparing the sedative and analgesic effects of magnesium sulphate versus fentanyl as adjuvants to propofol lidocaine admixture for conscious sedation in patients undergoing burr hole surgery for evacuation of subdural haematoma.

NCT ID: NCT03387644 Completed - Conscious Sedation Clinical Trials

Pregabalin Premedication for Conscious Sedation

Start date: April 15, 2015
Phase: N/A
Study type: Interventional

Conscious sedation is usually required during flexible bronchoscopy. Sedation should be done without causing respiratory depression or loss of consciousness. The present study was designed to evaluate the advantage of pregabalin pre-medication on reducing sedatives and respiratory depression for patients undergoing flexible bronchoscopy with dexmedetomidine and midazolam.

NCT ID: NCT03229148 Completed - Stroke Clinical Trials

Anesthesia Management in Endovascular Therapy for Ischemic Stroke

AMETIS
Start date: August 31, 2017
Phase: N/A
Study type: Interventional

Objective of the study: to assess whether pharmacological sedation or general anesthesia for treatment of anterior circulation ischemic stroke with endovascular mechanical thrombectomy is associated with difference in morbidity (neurological outcome and peri-procedural complications).

NCT ID: NCT03085563 Completed - Conscious Sedation Clinical Trials

A Comparison of Intranasal Midazolam and Nitrous Oxide (N2O) Minimal Sedation for Minor Procedures in a Pediatric Emergency Department

Start date: May 24, 2017
Phase: Phase 4
Study type: Interventional

The objective of this project is to compare the sedative effects of intranasal midazolam versus inhaled nitrous oxide (N2O) for minor procedures in the pediatric emergency department. The primary outcome will be length of stay (LOS) in the emergency department (ED) stay for minor procedures. Secondarily the investigators will compare patient/family and provider satisfaction while using either intranasal midazolam or N2O for minimal sedation. The investigators hypothesize that the total length of stay for children undergoing minor procedures in the ED will be lower for N2O, as compared to intranasal midazolam. The investigators also hypothesize that patient/family and provider satisfaction will be higher with N2O and adverse effects will not differ between N2O and intranasal midazolam. Patients will receive either intranasal midazolam or N2O for minor procedures. Following the enrollment period, data will be analyzed and the two will be compared. Total length of stay, patient/family and provider satisfaction will be studied.

NCT ID: NCT02679781 Completed - Conscious Sedation Clinical Trials

Nasal Versus Oral Midazolam Sedation in Routine Pediatric Dental Care

Start date: March 28, 2017
Phase: N/A
Study type: Interventional

The general objective of the study is to compare the efficacy of administering midazolam orally as syrup versus nasally with nasal atomizer. The specific objectives are to measure: 1) acceptability of the medication, 2) effect on behavior, 3) time of onset, 4) maximum working time.

NCT ID: NCT02518919 Completed - Conscious Sedation Clinical Trials

Procedural Sedation And Analgesia in Children in the Emergency Department: The Role of Adjunct Therapies

Start date: October 1, 2015
Phase: N/A
Study type: Interventional

The role of Adjunct therapies such as Child Life therapy and Music listening during Procedural Sedation and Analgesia(PSA) for children during painful procedures has not been studied in the Emergency Department (ED). The investigators hypothesize that there will be a reduction in sedation medication dosage without change in sedation efficacy by addition of music therapy and Child Life to standard sedation protocol in children 3-15 years of age who undergo PSA for painful (orthopedic procedures, laceration repair, incision and drainage) procedures in a Pediatric emergency Department (PED).

NCT ID: NCT01873612 Completed - Hypoxia Clinical Trials

Acute Ventilatory Response to Hypoxia During Sedation With Dexmedetomidine Compared to Propofol in Healthy Male Volunteers

Start date: May 2013
Phase: Phase 4
Study type: Interventional

The overall aim with this project is to investigate the effect of dexmedetomidine on control of breathing in healthy volunteers and to compare it with propofol at the same degree of sedation.