Study of the Litx™ System Combined With Chemotherapy in Patients With Colorectal Liver Metastases

Colorectal Neoplasms Clinical Trial

Official title:

Safety and Effectiveness of Treating Cancers With the Litx™ System and Chemotherapy. Section A: Phase II Safety and Effectiveness Study in Patients With Liver Metastases From Colorectal Cancer

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00083785
• Other study ID #: LSC-OL003
• Status: Completed
• Phase: Phase 2
• First received: June 2, 2004
• Last updated: April 10, 2007
• Start date: May 2004

Study information

• Verified date: April 2007
• Source: Light Sciences LLC
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Food and Drug Administration
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine whether the Litx™ system is safe and effective in combination with chemotherapy in the treatment of liver metastasis arising from colorectal cancer. Litx™ is a next-generation photodynamic therapy platform in which the drug, talaporfin sodium (LS11), is activated by light from the light-emitting diode (LED)-based light infusion device, inserted directly into the tumor through the skin prior to treatment.

Description:

Patients that provide Informed Consent and satisfy the Eligibility Criteria will undergo CT or Ultrasound guided percutaneous placement of a single, two, three, or four Light Sources depending on their tumor characteristics. No more than 4 Light Sources will be used at a single treatment. The Light Sources may be used in a single lesion or in multiple lesions.

Following radiographic confirmation of Light Source placement, patients will receive an intravenous dose of LS11 at 40 mg/m². Fifteen minutes to 1 hour following completion of LS11 administration, delivery of 200 J/cm at 20 mW/cm light energy will begin. The Light Source will then be manually removed and the patients will be observed for acute complication of Light Source removal. Precautions for protection from external light exposure should be instituted beginning with the LS11 administration and be maintained as defined throughout the study period. On day 3 following Litx™ treatment the patient will receive a standard chemotherapy with Irinotecan or Oxaliplatin with or without 5FU and /or leucovorin for metastatic colorectal cancer. On day 30+5 and day 60+5 the patient will undergo clinical assessment and the tumor mass will be imaged using contrast enhanced spiral CT for determination of volume and radius of PDT necrosis.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 25
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients with metastatic liver lesions from colorectal disease

• Biopsy proven evidence of colorectal cancer

• Patients with 4 or fewer lesions greater than 1 cm and with no single lesion greater than 7 cm in maximum diameter

• Age greater than or equal to 18 years

• Patients must be able to sign informed consent

• Life expectancy greater than or equal to 3 months

• ECOG performance status 0-2

• Patients with extrahepatic disease in addition to their hepatic metastases may be eligible

• Must have recovered from the toxicity from any prior antineoplastic therapy

Exclusion Criteria:

• Patients who are candidates for complete surgical resection

• Pregnancy or breast-feeding. A negative pregnancy test (urine or serum) is required prior to enrollment

• Known uncontrollable serious reactions such as anaphylaxis, to the contrast agents used in this study

• PT or PTT greater than 1.5X control

• Platelet count less than 100,000

• WBC less than 2500/mm

• Neutrophils less than 2000/mm

• Hemoglobin less than 9 g/dL

• Liver enzymes (AST, ALT, GGT, alkaline phosphatase) greater than 3 X ULN

• Total bilirubin greater than 1.5 X ULN

• Serum creatinine greater than 2.5 X ULN

• Patients who have been treated with either AVASTIN™ (Bevacizumab) or ERBITUX™ (Cetuximab) within the previous 4 weeks (28 days)

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Colorectal Neoplasms
• Liver Metastasis
• Liver Neoplasms
• Neoplasm Metastasis
• Neoplasms
• Neoplasms, Second Primary

Intervention

Drug:
• Talaporfin sodium (LS11)

Device:
• LED-based light infusion device

• Light emitting diodes (LED)

Procedure:
• Photodynamic therapy

• Phototherapy

• Chemotherapy

Locations

Country	Name	City	State
United States	Virginia Mason Medical Center	Seattle	Washington

Sponsors (1)

Lead Sponsor	Collaborator
Light Sciences LLC

Country where clinical trial is conducted

United States, 

References & Publications (2)

Chen J, Keltner L, Christophersen J, Zheng F, Krouse M, Singhal A, Wang SS. New technology for deep light distribution in tissue for phototherapy. Cancer J. 2002 Mar-Apr;8(2):154-63. — View Citation

Lustig RA, Vogl TJ, Fromm D, Cuenca R, Alex Hsi R, D'Cruz AK, Krajina Z, Turic M, Singhal A, Chen JC. A multicenter Phase I safety study of intratumoral photoactivation of talaporfin sodium in patients with refractory solid tumors. Cancer. 2003 Oct 15;98(8):1767-71. — View Citation