Apatinib for Resectable Colorectal Cancer

Colorectal Cancer Clinical Trial

Official title:

Apatinib With Postoperative Adjuvant Chemotherapy for Operable Colorectal Cancer

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT03228043
• Other study ID #: Apatinib in Colorectal Surgery
• Status: Withdrawn
• Phase: N/A
• Start date: March 1, 2020
• Est. completion date: March 1, 2023

Study information

• Verified date: January 2020
• Source: Nanchong Central Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Objective: To compare the outcome of patients with colorectal cancer who treated with adjuvant therapy or Apatinib with adjuvant therapy postoperatively.

Language: English.

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: March 1, 2023
• Est. primary completion date: March 1, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

1. ECOG performance status score: 0-1.

2. All colorectal cancer patients underwent curative intent surgery

3. Patients in stage ?(Any T, N0, M0) with multiple high-risk factors or stage ? (any T, N1-2, M0) which confirmed by pathology.

4. Patients who did not receive other treatments for colorectal adenocarcinoma after surgery;

5. The main organ function is good, patients must meet the following requirements with 14 days before using Apatinib:

• blood routine examination:

• hemoglobin> 90 g / L (14 days without blood transfusion);

• neutrophil count> 1.5 x 109 / L;

• platelet count> 100 × 109 / L;

• biochemical examination:

• total bilirubin = 1.5 × ULN (normal upper limit);

• alanine aminotransferase (ALT) or aspartate aminotransferase (AST) = 2 × ULN;

• Endogenous creatinine clearance = 60 ml / min (Cockcroft-Gault formula);

• Cardiac Doppler Ultrasonography: Left ventricular ejection fraction (LVEF) = 50%.

6. The surgical incision has been healed, and no bleeding tendency;

7. Sign informed consent;

8. Compliance is good, family members agreed to accept survival follow-up.

Exclusion Criteria:

1. Patients with other malignancies, except for cured skin basal cell carcinoma and cervical cancer in situ.

2. Participated in other drug clinical trials within four weeks.

3. Have a variety of factors that affect oral medication (such as unable to swallow, chronic diarrhea and intestinal obstruction, etc.).

4. Have a history of bleeding, screening within 4 weeks before any serious grade to CTCAE4.0 3 degrees or more bleeding events.

5. Patients with central nervous system metastases or a history of central nervous system metastases before screening. For patients with suspected central nervous system metastases, CT or MRI examinations must be performed within 28 days prior to randomization to exclude central nervous system metastasis.

6. History of high blood pressure can not be controlled with a single antihypertensive drug therapy (With a systolic blood pressure> 140 mmHg, diastolic blood pressure> 90 mmHg. A history of unstable angina within 3 months or a new diagnosis of angina within 6 months (Including QTcF: male = 450 ms, female =470 ms) required long-term use of antiarrhythmic drugs and New York Heart Association classification = Class II cardiac insufficiency.

7. Urinary protein = ++ and urine protein> 1.0 g in 24 hours.

8. Patients with anastomotic fistula, pancreatic fistula or anastomotic stenosis and other serious postoperative complications.

9. Long-term non-healing wounds or bone fractures.

10. history of organ transplantation.

11. Imaging shows that the tumor has involved important vascular. Patients in high risk of fatal bleeding during treatment.

12. coagulation abnormalities, with bleeding tendency (14 days before randomization must meet: in the absence of anticoagulants, INR in normal range). application of anticoagulants or vitamin K antagonists such as warfarin, (1 mg orally, once daily) or low-dose aspirin (1 mg or less daily) at a prokaryotic time (INR) = 1.5 Daily consumption of not more than 100 mg).

13. During the last year, the history of tachycardia / venous thrombosis events, such as cerebrovascular accident (including transient ischemic attack), deep venous thrombosis (due to pre-chemotherapy intravenous thrombosis caused by intravenous thrombosis which have been cured ) And pulmonary embolism.

14. previous thyroid dysfunction, thyroid function can not be maintained within the normal range during medication.

15. with a history of psychiatric drug abuse and can not be prevented or have mental disorders.

16. Have a history of immunodeficiency, or suffer from other acquired, congenital immunodeficiency disease, or organ transplant history.

17. According to the researcher's judgment, there is a serious risk of compromising the patient's safety or affecting the patient's completion of the study.

Related Conditions & MeSH terms

• Adjuvant Chemotherapy
• Apatinib
• Colorectal Cancer
• Colorectal Neoplasms
• Outcome, Fatal
• Surgery

Intervention

Drug:
• Apatinib
Apatinib combine with CAPEOX adjuvant chemotherapy for resectable colorectal
• CAPEOX
CAPEOX adjuvant chemotherapy for resectable colorectal

Locations

Country	Name	City	State
China	Yunhong Tian	Nanchong	Sichuan

Sponsors (1)

Lead Sponsor	Collaborator
Nanchong Central Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Number of Participants recurrence-free survival	Number of Participants recurrence-free survival in intervention group and control group.	3 years
Other	Number of Participants overall survival	Number of Participants overall survival in intervention group and control group.	3 years
Other	Number of Participants recurrence-free survival	Number of Participants recurrence-free survival in intervention group and control group.	4 years
Other	Number of Participants overall survival	Number of Participants overall survival in intervention group and control group.	4 years
Other	Number of Participants recurrence-free survival	Number of Participants recurrence-free survival in intervention group and control group.	5 years
Other	Number of Participants overall survival	Number of Participants overall survival in intervention group and control group.	5 years
Primary	Number of Participants recurrence-free survival	Number of Participants recurrence-free survival in intervention group and control group.	1 year
Primary	Number of Participants overall survival	Number of Participants overall survival in intervention group and control group.	1 year
Secondary	Number of Participants recurrence-free survival	Number of Participants recurrence-free survival in intervention group and control group.	2 years
Secondary	Number of Participants overall survival	Number of Participants overall survival in intervention group and control group.	2 years