Colorectal Cancer Clinical Trial
Official title:
Efficacy and Safety of PIPAC/PITAC With Cisplatin and Doxorubicin in Gastric, Ovarian and Colorectal Cancer With Peritoneal Carcinomatosis and Oxaliplatin in Patients With Mesothelioma/Pleural Cancer With Pleural Carcinomatosis.
Outcome measurement for patients with gastric, ovarian, colorectal, or pleural cancer/mesothelioma with peritoneal/pleural carcinomatosis undergoing pressurized intraperitoneal/intrathoracal aerosol chemotherapy (PIPAC/PITAC) with cisplatin and doxorubicin or oxaliplatin. Record of (partial/total) tumor response rate via survival rate, time until tumor progression (according to RECIST-criteria), peritoneal carcinomatosis index (PCI) before and after therapy, histological tumor progression/regression, ascites/pleural affusion volume, degree of tumor cell apoptosis.
Outcome data for 200 patients (50 patients each of with gastric, ovarian, colorectal, or
pleural cancer/mesothelioma with peritoneal/pleural carcinomatosis) undergoing pressurized
intraperitoneal/intrathoracal aerosol chemotherapy (PIPAC/PITAC) with cisplatin and
doxorubicin or oxaliplatin.
The indication depends on the tumor entity and spread, the previous chemotherapeutic therapy
and the patient's condition. If these are matched and the indication for PIPAC/PITAC therapy
is provided by a multidisciplinary Tumorboard, the patient will be offered to undergo
PIPAC/PITAC therapy. Despite PIPAC/PITAC therapy entails an off label use of the
chemotherapeutic agents, health insurance covers the treatment for carefully selected
patients after special approval. With this observational study, the Klinik Hirslanden aims
at monitoring treated patients and to evaluate the safety and efficacy properties of
PIPAC/PITAC treatment.
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Observational Model: Cohort, Time Perspective: Prospective
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