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Colorectal Cancer clinical trials

View clinical trials related to Colorectal Cancer.

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NCT ID: NCT05483179 Completed - Colorectal Cancer Clinical Trials

Association Between New Effort-independent Cardiopulmonary Exercise Test Variables and Postoperative Complications After Elective Colorectal Surgery

Start date: April 15, 2022
Study type: Observational

A cardiopulmonary exercise test (CPET) is increasingly used for preoperative risk assessment. Oxygen uptake (VO2) at peak exercise (VO2peak) and VO2 at the ventilatory anaerobic threshold (VO2VAT) are the most commonly used preoperative CPET variables that are associated with postoperative outcomes following colorectal cancer surgery. The aim of this study is to investigate the association between two relatively new preoperative submaximal and effort-independent CPET variables, the cardiopulmonary optimal point (COP) and the Oxyen uptake efficiency plateau (OUEP) and postoperative outcomes in colorectal cancer surgery. In additiion, the association between the oxygen uptake at the COP en OUEP and postoperative outcomes wil be explored.

NCT ID: NCT05462470 Completed - Colorectal Cancer Clinical Trials

Impact of Surgical Management for Relapse After Conversion Hepatectomy for Initially Unresectable Colorectal Liver Metastasis

Start date: January 1, 2008
Study type: Observational

For patients with initially unresectable colorectal liver metastasis (IU-CRLM) receiving effective conversion therapy, disease relapse after conversion hepatectomy is common due to the extensive tumor load. Yet, few studies have focused on the assessment and management of relapse after conversion hepatectomy for IU-CRLM. This study aimed to investigate the impact of surgical management for relapse after conversion hepatectomy in IU-CRLM.

NCT ID: NCT05420415 Completed - Colorectal Cancer Clinical Trials

The CSTME Associates With the Prognosis of Stage II and III Colorectal Cancer

Start date: September 1, 2018
Study type: Observational

Colorectal cancer (CRC) is the second most commonly occurring cancer worldwide. Thirty-five percent of CRC patients are diagnosed at stage II/III, and their outcome differs even if they are in the same stage. Previous study found that the microenvironmental collagen is associated with tumor progression and metastasis. Whether tumor microenvironmental collagen signature is associated with colorectal cancer prognosis still remains unknown. We hypothesize that the tumor microenvironmental collagen signature of colorectal cancer is associated with prognosis.

NCT ID: NCT05414461 Completed - Colorectal Cancer Clinical Trials

Efficacy of Combination Immunotherapy in Patients With Metastatic Colorectal Cancer

Start date: March 10, 2019
Phase: Phase 2
Study type: Interventional

Immunotherapy improved efficacy and survival in selective patients with metastatic colorectal cancer (mCRC), however, limited data revealed the landscape of immunotherapy efficacy. What's more, potential markers have not been comprehensively evaluated to identify responding patients to further improve efficacy.The investigators conducted a single-arm study to investigate the efficacy of combination immunotherapy in patients with mCRC, and the combined regimen is determined by the physician in charge.

NCT ID: NCT05374369 Completed - Colorectal Cancer Clinical Trials

Retrospective Analysis of Colorectal Cancer Screening Results

Start date: March 29, 2022
Study type: Observational

The purpose of this study is to retrospectively analyze colorectal cancer screening data of 40-74 year old population in Shipai Town, Dongguan City. In this study, the data of SDC2 Gene Methylation Test and Fecal Immunochemistry Test (Q-FIT) were screened from about 11,000 subjects who participated in Colorectal Cancer Screening in Shipai Town People's Livelihood Project from May 2021 to May 2022. Data from 822 subjects with positive SDC2 Gene Methylation Test and/or positive Fecal Immunochemistry Test (Q-FIT) results and with colonoscopy and/or pathological results were selected for retrospective analysis. This retrospective study evaluated the screening performance of SDC2 Gene Methylation Test and/or Fecal Immunochemistry Test (Q-FIT) for colorectal cancer using colonoscopy and/or pathological results as the clinical standard method.

NCT ID: NCT05290480 Completed - Colorectal Cancer Clinical Trials

Expiratory Muscle Training Versus Incentive Spirometry After Colorectal Surgery

Start date: January 1, 2018
Phase: N/A
Study type: Interventional

The aim of this study was to compare the effects of expiratory muscle training (EMT) and incentive spirometry (IS) in addition to conventional pulmonary rehabilitation after colorectal surgery. Twenty-four individuals (13 male) undergoing colorectal surgery were included. They were randomly divided into two groups. In addition to conventional chest physiotherapy, group 1 was performed EMT (n=12), group 2 was performed deep breathing exercises with incentive spirometry (IS) in postoperative period. Respiratory muscle strength, functional capacity, levels of movement and independence, and postoperative pulmonary complications (PPC) were evaluated. Length of stay in hospital (LOS) was recorded.

NCT ID: NCT05278728 Completed - Colorectal Cancer Clinical Trials

Phase IIa Study of Nimotuzumab to Treat Colorectal Cancer

Start date: July 2009
Phase: Phase 1/Phase 2
Study type: Interventional

Nimotuzumab is an IgG1 humanized monoclonal antibody that recognized an epitope located in the extra cellular domain of the human epidermal growth factor receptor (EGFR). Clinical efficacy has been shown in adult with head and neck cancer. The study assessed the safety, and efficacy of the combination of Nimotuzumab administered concomitantly with chemotherapy in patients with advanced colorectal cancer.

NCT ID: NCT05261542 Completed - Colorectal Cancer Clinical Trials

Intraoperative Flow Cytometry In Colorectal Cancer

Start date: January 26, 2017
Study type: Observational

This study was designed to investigate the efficacy of flow cytometry to accurately identify between normal and cancer cells in colon epithelium in humans diagnosed with colorectal cancer.

NCT ID: NCT05182762 Completed - Colorectal Cancer Clinical Trials

Measuring Quality in Colorectal Cancer Surgery in Low- and Middle-income Countries

Start date: February 1, 2020
Study type: Observational

To test the applicability of the Clavien-Dindo Classification (CDC) in an LMIC setting and to compare the prevalence and severity of complications in patients <60 and ≥60 years of age a retrospective medical records review is used.

NCT ID: NCT05180565 Completed - Colorectal Cancer Clinical Trials

Safe Anastomosis Feasibility Study

Start date: December 18, 2019
Phase: N/A
Study type: Interventional

A clinical trial to assess the efficacy, mechanism of action and safety of the Colovac+ Colorectal Anastomosis Protection Device in providing temporary protection of the anastomosis in subjects undergoing lower anterior resection for colorectal cancer