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Clinical Trial Summary

This study is a single-arm, open-label, dose-escalating + dose-expansion clinical study, aiming to evaluate the safety and efficacy of CEA-targeted CAR-T cell preparations, and to preliminarily observe the study drug in CEA-positive advanced malignant tumors. The pharmacokinetic characteristics of CAR-T cell preparations for the treatment of patients with CEA-positive advanced malignancies were obtained and the recommended dose and infusion schedule.


Clinical Trial Description

According to the different infusion methods, it is divided into two subgroups: intravenous infusion and local infusion through the peritoneal cavity. Each subgroup includes a dose exploration stage (Part A) and a dose expansion stage (Part B). 3 patients were explored, starting from the low-dose group, and in the dose expansion phase, the safety and efficacy were further verified according to the safe recommended dose obtained in the dose exploration phase. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06006390
Study type Interventional
Source Chongqing Precision Biotech Co., Ltd
Contact Qi Mei, M.D
Phone 15871708675
Email borismq@hotmail.com
Status Recruiting
Phase Phase 1/Phase 2
Start date September 7, 2023
Completion date August 31, 2026

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