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Colon Cancer clinical trials

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NCT ID: NCT03475680 Terminated - Colon Cancer Clinical Trials

Mechanical Bowel Preparation and Oral Antibiotics Before Colon Cancer Surgery

COLONPREP
Start date: August 8, 2018
Phase: Phase 3
Study type: Interventional

This study aims to demonstrate that a preoperative combination of mechanical bowel preparation and oral antibiotics, before elective laparoscopic colon cancer surgery, is associated with a reduction of postoperative surgical site infection rate, as compared to mechanical bowel preparation alone, oral antibiotics alone, or no colonic preparation. Our Hypothesis is that a preoperative colonic preparation including a combination of mechanical bowel preparation and oral antibiotics before elective laparoscopic colon cancer surgery is associated with a reduced rate of 30-day postoperative surgical site infection, as compared to mechanical bowel preparation alone, oral antibiotics alone, or no colonic preparation.

NCT ID: NCT03471494 Completed - Gastric Cancer Clinical Trials

GlobalSurg 3: Quality and Outcomes in Global Cancer Surgery

GS3
Start date: April 1, 2018
Phase:
Study type: Observational

Aim The aim is to determine the variation in quality of cancer surgery worldwide. Quality will be determined using measures covering infrastructure, care processes, and outcomes. The study will concentrate on the most common surgically treated cancers worldwide: breast, gastric and colorectal cancer. The primary aim focusses on 30-day mortality and complication rates after cancer surgery. The secondary aim is to characterise infrastructure and care processes in the treatment of these cancers worldwide. Primary outcome measure 30-day mortality and complication rates after cancer surgery. Primary comparison Between country groups defined by human development index. Hospital eligibility Any hospital in the world performing surgery for breast, gastric or colorectal cancer. Patient eligibility Consecutive patients undergoing surgery for breast, gastric, or colorectal cancer. Surgery can be with palliative or curative intent. Team Individual hospital teams with up to three people, collecting data for four weeks. Several teams collecting data over multiple four-week periods is encouraged. Time period Patients will be identified, and data collected on all patients during the time-period with follow-up to 30-days. The study will run from 1st April 2018 to 31st October 2018 (with follow-up of the last period to 30th November 2018). Validation Data validation will be in two parts. First, centres will self-report the key processes used to identify and follow-up patients. Second, independent validators will quantitatively report case ascertainment and sampled data accuracy.

NCT ID: NCT03464305 Active, not recruiting - Colon Cancer Clinical Trials

ASPIRIN Trial Belgium

ASPIRIN
Start date: February 22, 2018
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether acetylsalicylic acid is effective on the recurrence and survival of colon cancer patients.

NCT ID: NCT03462706 Completed - Colon Cancer Clinical Trials

Quad Resection (Hot Snare vs Cold Snare vs Hot EMR vs Cold EMR)

Start date: February 6, 2018
Phase: N/A
Study type: Interventional

The study will compare the use of cold snare, hot snare, cold EMR, and hot EMR for polyp resection. Although previous studies have compared two of the potential resection methods, no previous study has evaluated all four of the resection methods.

NCT ID: NCT03457454 Completed - Colon Cancer Clinical Trials

Reducing Rural Colon Cancer Disparities

Start date: September 8, 2017
Phase:
Study type: Observational

The investigators will conduct pre-implementations assessments of primary care clinics within a rural health system to determine current practices and capacities regarding colorectal cancer (CRC) screening and follow-up, preferred evidence-based interventions (EBIs) to improve follow-up, and factors that could influence successful implementation and eventual impact of a multi-level intervention to increase timely and complete follow-up after positive fecal occult blood test (FOBT) in rural patients.

NCT ID: NCT03446157 Active, not recruiting - Colon Cancer Clinical Trials

Palbociclib and Cetuximab in Metastatic Colorectal Cancer

Start date: March 13, 2018
Phase: Phase 2
Study type: Interventional

This research study is designed to provide a better understanding of study drugs cetuximab (Erbitux®) and palbociclib when used in combination to treat patients with metastatic colon cancer.

NCT ID: NCT03442569 Active, not recruiting - Colon Cancer Clinical Trials

PhII Trial Panitumumab, Nivolumab, Ipilimumab in Kras/Nras/BRAF Wild-type MSS Refractory mCRC

Start date: March 9, 2018
Phase: Phase 2
Study type: Interventional

To investigate the combination of nivolumab and ipilimumab with panitumumab in subjects with unresectable, refractory, KRAS/NRAS/BRAF wild-type, microsatellite stable (MSS) metastatic colorectal cancer.

NCT ID: NCT03435666 Not yet recruiting - Breast Cancer Clinical Trials

A Bioequivalence Study of Capecitabine Tablets 500 mg in Adult Cancer Patients Under Fed Condition

Capecitabine
Start date: May 2018
Phase: Phase 1
Study type: Interventional

Purpose: To demonstrate the bioequivalence between Capecitabine Tablets 500 mg of Qilu Pharmaceutical Co., Ltd, China in comparison with XELODA® (Capecitabine) Tablets 500 mg, Distributed by Genentech USA, Inc. Design: two treatment, three period, three sequence, reference replicate crossover, single dose. Test Drug: Capecitabine Tablets; Reference drug: XELODA Sample size: Around 45 patients will be enrolled to have at least 39 evaluable patients in the study.

NCT ID: NCT03434925 Recruiting - Colon Cancer Clinical Trials

Multi Parametric Test Predicting the Risk of Colorectal Neoplasia Recurrence

Start date: April 1, 2017
Phase: N/A
Study type: Interventional

This project is dedicated to identify the patients with possible higher risk of adenoma recurrence who should have follow-up colonoscopy in yearly interval. As a result, it can lead to optimizing the of follow-up colonoscopies intervals in real-world practice.

NCT ID: NCT03432806 Active, not recruiting - Colon Cancer Clinical Trials

A Study of Imaging, Blood, and Tissue Samples to Guide Treatment of Colon Cancer and Related Liver Tumors

Start date: November 28, 2017
Phase:
Study type: Observational

The purpose of this study is to explore novel ways of diagnosing colon cancer and predicting its propensity to spread to other organs such as the liver.