Cognitive Enhancement in Depression (The COG-D Study)

Status Recruiting

Clinical Trial Summary

This study will investigate whether transcranial direct current stimulation (tDCS) enhances the effects of cognitive training in older adults with depression.

Clinical Trial Description

The purpose of this study is to determine whether the addition of active tDCS to computerized cognitive remediation (nCCR) enhances brain activity and cognitive functions in older adults with depression to a greater degree than nCCR with sham stimulation. The investigators will randomize 20 elderly depressed outpatients to either double-blinded active or sham bifrontal tDCS plus daily nCCR over 4-weeks. Multimodal MRI (focused on the cognitive control network; CCN) and psychiatric and neuropsychological evaluations will be obtained at baseline and following intervention completion. Long-term CCN cognitive effects will be explored 3-months post-intervention via cognitive assessments. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05400512
Study type	Interventional
Source	Vanderbilt University Medical Center
Contact	Sarah M. Szymkowicz, PhD
Phone	615-875-0032
Email	sarah.szymkowicz@vumc.org
Status	Recruiting
Phase	N/A
Start date	February 8, 2023
Completion date	September 2024

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