Effects of Transcranial Magnetic Stimulation to the Cerebellum on Cognition

Cognitive Performance Clinical Trial

Official title:

fMRI and TMS Analysis of Cerebellar Cognitive Function

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00740701
• Other study ID #: NA_00044841
• Secondary ID: R01MH060234
• Status: Completed
• Phase: N/A
• Start date: April 2000
• Est. completion date: January 2005

Study information

• Verified date: August 2018
• Source: Johns Hopkins University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Functional neuroimaging studies have shown that the cerebellum is active during cognitive performance. The investigators hypothesize that stimulation of the cerebellum with transcranial magnetic stimulation will produce brief changes in performance of the task, suggesting that cerebellar activation is necessary for normal cognitive function.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 17
• Est. completion date: January 2005
• Est. primary completion date: January 2005
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 19 Years to 30 Years

Eligibility

Inclusion Criteria:

• 19-30 years of age

• Informed consent

Exclusion Criteria:

• History of seizure or a family history of epilepsy

• History of stroke

• Presence of metal anywhere in the head except the mouth

• Presence of cardiac pacemakers

• Presence of cochlear implants

• Presence of implanted medication pump

• History of heart disease

• Presence of intracardiac lines

• Increased intracranial pressure, such as after infarctions or trauma

• Children, or outside of age range

• Pregnancy

• Currently taking tricyclic anti-depressants or neuroleptic medication

• History of head trauma

• History of respiratory disease

Related Conditions & MeSH terms

• Cognitive Performance

Intervention

Device:
• Cerebellar transcranial magnetic stimulation
single pulse TMS or repetitive TMS at 1 Hz frequency

Locations

Country	Name	City	State
United States	Kennedy Krieger Institute	Baltimore	Maryland

Sponsors (3)

Lead Sponsor	Collaborator
Johns Hopkins University	National Institute of Mental Health (NIMH), National Institute on Aging (NIA)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Behavioral performance (accuracy, or rate of conditioned responses)		during computerized task performance (2 hours)
Secondary	Reaction time		during performance of computerized task (2 hours)