Clinical Trials Logo

Clinical Trial Summary

The objective of this study is to simultaneously establish the metrological characteristics of the new executive function markers (decision making and multiple flow management) derived from repeated ERP variations and to identify their ability to test whether a short treatment using Ginkgo biloba versus placebo extracts can modify the cognitive performance and functional capacity of patients in the very early stages of age-related cognitive decline. This trial, using subjects as their own control (cross-over) in repeated measurements will establish the reproducibility characteristics of the measurements and intra-individual variations of ERP over time in this population


Clinical Trial Description

This study is a single-center, randomized clinical trial testing the effects of Ginkgo biloba extracts versus placebo on event related potential ERP registration measurements in Electroencephalography (EEG) during neuropsychological tasks. The Hold-Release (HR) neuropsychological test allows the study of behavioral and neurofunctional correlates using several different techniques for online recording of brain activity. This test measures the engagement of focused attention and the loading of information into working memory, as opposed to the disengagement of attention. The study will be carried out in a randomized cross-over design, with "Ginkgo" vs. Placebo", or inversely, for 170 days each (approximately 6 months), separated by an 8-weeks wash-out period. A follow-up visit will be held 3 months after the last treatment of the study. The cross-over design uses each patient as its own control, which allows an easy comparison between the 2 groups "Placebo" vs. "Ginkgo" by limiting inter-patient variations. In addition, by doubling the number of patients per treatment compared to a classic study design in 2 groups, cross-over reduces the number of patients to be recruited, which facilitates recruitment on a single site. The study requires the recruitment of sixteen (16) informative participants with cognitive complaints. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04121728
Study type Interventional
Source University of Lausanne Hospitals
Contact
Status Active, not recruiting
Phase N/A
Start date September 9, 2019
Completion date May 31, 2024

See also
  Status Clinical Trial Phase
Enrolling by invitation NCT04641663 - Multi-target Dietary Supplement Tolerability in an Aging Population (MTDSST) N/A
Completed NCT03228446 - The Effects of Attentional Filter Training on Working Memory N/A
Completed NCT04910399 - Development of an Innovative Health Ingredient From Marine By-products for the Healthy Aging N/A
Recruiting NCT03275363 - The University of Hong Kong Neurocognitive Disorder Cohort N/A
Completed NCT02185222 - Effect of Vitamin D on Cognitive Decline of Patients With Memory Complaint Phase 3
Active, not recruiting NCT03162913 - The Effects of Strawberry Supplementation on Memory and Gait Among Over-weight Older Adults N/A
Completed NCT02416401 - Attention Training for Learning Enhancement and Resilience Trial N/A
Completed NCT02922920 - Effects of Tart Cherry Juice on the Body N/A
Completed NCT01120860 - Magnetic Resonance Imaging (MRI) and Decline of Aging Aviator Performance N/A
Recruiting NCT03702335 - Impact of Comprehensive Dietary Counseling on Dietary Quality, Mental Health, and Quality of Life in Older Adults N/A
Completed NCT05828043 - Brain Aging: Muscle-to-brain Axis Modulates Physio-cognitive Decline N/A
Recruiting NCT05348694 - OsteoPreP: Food Supplements for Postmenopausal Bone Health Phase 4
Recruiting NCT05194787 - TAS Test: Online Motor-cognitive Tests for Early Detection of Alzheimer's Disease
Recruiting NCT04184375 - Cognitive Stimulation for Elderly Bipolar Patients N/A
Recruiting NCT04171323 - The Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia N/A
Not yet recruiting NCT06248723 - ItaliaN Study With Tailored Multidomain Interventions to Prevent Functional and Cognitive Decline in Community-dwelling Older Adults N/A
Terminated NCT04732312 - Impact of Formal Home Help on Quality of Life for Caregivers of Elderly Patients With Neurocognitive Impairment
Not yet recruiting NCT04566757 - Safety and Efficacy of Human Umbilical Cord Blood Plasma Infusion for Age-Related Cognitive Decline Phase 1
Completed NCT01596205 - The Efficacy of Robot Assisted Group Cognitive Training in Elderly Adults Without Cognitive Impairment N/A
Recruiting NCT05728801 - Decoding the Cognitive Trajectory of Hong Kong SuperAgers: a Longitudinal Follow-up Study