EUS vs TJ for Liver Biopsy and Portal Pressure Gradient Measurement

Cirrhosis Clinical Trial

Official title: Endoscopic Ultrasound Guided Liver Biopsy and Portal Pressure Gradient Measurement Compared to the Transjugular Approach: a Randomized Controlled Trial

Status Recruiting

Clinical Trial Summary

This study will directly compare the endoscopic ultrasound guided approach to obtain adequate liver biopsies and portal pressure gradient measurements to the current standard of care which uses the transjugular approach.

Clinical Trial Description

Current guidelines recommend that when a hepatic venous pressure gradient and a liver biopsy are needed, the liver biopsy should be done by the transjugular approach during the same session. A major limitation is that liver biopsies obtained by the transjugular approach meet quality criteria proposed by the American Association for the Study of Liver Diseases (at least 2-3cm with at least 11 complete portal tracts) in only 40% of cases.

Recent studies have shown that endoscopic ultrasound-guided liver biopsy (EUS-LB) can achieve a high rate of adequate liver biopsies using the same strict criteria described above. In addition, a novel endoscopic-ultrasound adapted manometer allows the safe and accurate measurement of portal pressure gradient (PPG) which correlates well with hepatic venous pressures (HVPG) obtained by the transjugular approach. Unfortunately to this day, no randomized controlled trials has compared the EUS-LB and PPG vs TJ-LB and HVPG directly. ;

Related Conditions & MeSH terms

• Chronic Liver Disease
• Cirrhosis
• Hypertension, Portal
• Liver Diseases
• Portal Hypertension

• NCT number: NCT05118308
• Study type: Interventional
• Source: McGill University Health Centre/Research Institute of the McGill University Health Centre
• Contact: Amine Benmassaoud, MD
• Phone: 514-843-1421
• Email: amine.benmassaoud@mcgill.ca
• Status: Recruiting
• Phase: N/A
• Start date: November 4, 2021
• Completion date: December 4, 2023