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Propranolol, Carvedilol and Rosuvastatin in the Prevention of Variceal Bleeding in Cirrhotic Portal Hypertension — Betastatin  

Cirrhosis Clinical Trial

Official title:
Propranolol, Carvedilol and Rosuvastatin in the Prevention of Recurrent Variceal Haemorrhage in Patients With Cirrhotic Portal Hypertension

Clinical Trial Summary

Patients with hepatic cirrhosis and previous variceal bleeding will be randomly assigned to use propranolol or carvedilol. After 8 weeks, rosuvastatin or placebo will be blindly added to nonresponders (HVPG measurement > 12mmHg) for another 8 weeks and hemodynamic response will be assessed again.

Surrogate serum markers of portal hypertension will be evaluated and correlated to HVPG values and to its variations.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03720067
Study type Interventional
Source Universidade Federal do Rio de Janeiro
Contact Guilherme FM Rezende, MD, PhD
Phone (5521)999976292
Email guimottarezende@gmail.com
Status Recruiting
Phase Phase 2/Phase 3
Start date January 25, 2019
Completion date December 20, 2022
View Details
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