Hypertension Clinical Trial
Official title:
Effects of an Exercise Program in Patients With Hypertensive Chronic Kidney Disease: a Randomized Clinical Trial
Introduction: Chronic kidney disease (CKD) is now an important public health issue. While
0.1% of the population is on dialysis, approximately 4.5% of subjects have renal dysfunction
(glomerular filtration rate <60 ml/min/1.73 m2). These patients have a high mortality of
cardiovascular disease (CVD) with low quality of life and survival, despite high expenditure
on their treatment. Hypertension (SAH) is both a cause and a complication of CKD. In
addition, CKD and hypertension are risk factors for CVD. The nephropathy that are not on
dialysis are less studied than those on dialysis. Strategies are needed to maintain renal
function in these patients and mitigate the risk factors for CVD. A sedentary lifestyle can
be an important determinant of morbidity of mortality. This study aims to determine the
effect of exercise in patients with CKD not yet on dialysis.
Methodology: A randomized clinical trial in hypertensive patients with CRF. After
recruitment of participants and completed baseline surveys, those eligible for inclusion and
consented to participate in the study will be randomly assigned. We use the technique of
randomization in blocks of fixed size of six persons.
Variables to be collected: demographic, socioeconomic, behavioral, anthropometric, blood
pressure, laboratory tests (anemia, the lipid profile, blood glucose, inflammatory markers
and number of peripheral endothelial progenitor cells) and quality of life. These patients
will be re-interviewed in the middle period of the study (10 weeks) at the end of the
intervention (20 weeks) and 10 weeks after the end of the intervention. The intervention
group will participate in two weekly sessions of exercise.
Therefore, facing the epidemic of CKD, this study intends to fill the data gaps about the
impact of physical activity in patients with CKD on dialysis.
Eligibility:
Individuals hypertensives diagnosed with GFR between 15 and 59 ml/min./1.73m2
Will be excluded from the study following patients:
- Diabetes mellitus;
- Severe physical disability
- Acute myocardial infarction in the last six months;
- Uncontrolled hypertension (systolic pressure> 180 mmHg and / or diastolic pressure> 110
mmHg);
- Angina at rest (unstable) or triggered by exercise;
- Congestive heart failure (> class II New York Heart Association; table X);
- Cardiac arrhythmias (> Lown class II,> 30 premature beats per minute);
- Subjects with prior renal transplant or dialysis.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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