Motivational Behavioral and Functional MRI Impairment in Patients With Chronic Neuropathic Pain

Chronic Pain Clinical Trial

— MOTION  

Official title:

Motivational Behavioral and Functional MRI Impairment in Patients With Chronic Neuropathic Pain

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05701852
• Other study ID #: HBD_2022_6
• Status: Not yet recruiting
• Start date: December 2023
• Est. completion date: May 2025

Study information

• Verified date: December 2023
• Source: Fondation Ophtalmologique Adolphe de Rothschild
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The main hypothesis of this study is that the alteration of the reward circuitry underlying the motivational deficit in chronic pain patients compared to healthy subjects results in a decrease in the capacity for reward learning. The fMRI studies have shown that this type of learning depends on the dopaminergic system innervating key regions of the reward system.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 50
• Est. completion date: May 2025
• Est. primary completion date: May 2025
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• For cases: patients managed in the neurosurgery department or at CETD for chronic neuropathic pain, of central or peripheral origin.

• For controls: matched to a case on age (±5 years) and sex

Exclusion Criteria:

• Neurodegenerative or inflammatory neurological pathology

• Clinical depressive syndrome

• High doses of opioid treatment (greater than 100 mg/day of morphine equivalent)

• Impaired judgment or inability to receive information that does not allow the performance of behavioral tasks

• Absolute contraindication to MRI (e.g. pacemaker, implantable pacemaker, metallic intra-orbital foreign body)

Related Conditions & MeSH terms

• Chronic Pain
• Neuralgia

Intervention

Other:
• reward learning task
during usual follow-up patients will complete a remard learning task questionnaire. This questionnaire cannot be assimilated to a clinical intervention.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Fondation Ophtalmologique Adolphe de Rothschild

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	To compare reward learning ability in patients with chronic neuropathic pain compared with an age (±5 years) and gender-matched control population	the reward learning ability will be assessed using a specific task. The result of the task questionnaire is a numeric score.	Day 0