Immune Mechanisms of Vitamin D to Reduce Chronic Pain After Burn

Status Recruiting

Clinical Trial Summary

The goal of this pilot clinical trial is to learn whether vitamin D is able to prevent chronic pain following burn injury and to determine what biological mechanisms are engaged by Vitamin D following burn injury. The main question[s] it aims to answer are: - Is the clinical trial protocol feasible? - Is Vitamin D administration following burn injury safe? - How does vitamin D cause changes in the immune system in the aftermath of burn injury? Following informed consent, participants will be asked to: - Take 6 capsules by mouth one time following burn injury (Vitamin D or Placebo) - Provide a blood sample at baseline and 6 weeks following injury - Fill out surveys daily while in the hospital, weekly through 6 weeks, and at 3 months and 6 months. Researchers will compare Vitamin D and placebo groups to see if there are differences in adverse effects (side effects), chronic pain, and profiles of immune cells from collected blood samples.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05619289
Study type	Interventional
Source	University of North Carolina, Chapel Hill
Contact	Matthew Mauck
Phone	919-966-5136
Email	matt_mauck@med.unc.edu
Status	Recruiting
Phase	Phase 2
Start date	April 12, 2023
Completion date	July 2025

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