Insomnia and Cognitive Performance in Chronic Pain

Chronic Pain Clinical Trial

Official title:

Distinct Effect of Insomnia on Cognitive Performance in Individuals With Complex Chronic Pain

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03072745
• Other study ID #: 2010/182
• Status: Completed
• Phase: N/A
• First received: March 2, 2017
• Last updated: March 2, 2017
• Start date: January 1, 2011
• Est. completion date: June 1, 2012

Study information

• Verified date: March 2017
• Source: Uppsala University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of the present study is to examine cognitive function in a patient population with complex chronic pain to test the hypothesis that insomnia severity on its own predicts objective cognitive function, and that a correlation is not better explained by comorbid depression or anxiety, morphine equivalent daily dose, or the level of pain itself.

Description:

Almost 20 % of the adult European population suffers from chronic pain of moderate to severe intensity, and clinical insomnia has been reported in 53-73% of chronic pain patients. Insomnia seems to be correlated with small to moderate impairments in several cognitive functions involved in working and episodic memory and in attention tasks, and chronic pain has been shown to be associated with objective deficits in memory and executive functioning. The aim of the present study is to examine cognitive function in a patient population with complex chronic pain to test the hypothesis that insomnia severity on its own predicts objective cognitive function, and that a correlation is not better explained by comorbid depression or anxiety, morphine equivalent daily dose, or the level of pain itself.

Inividuals with complex chronic pain are assessed with a neuropsychological test battery examining different aspects of memory and executive functioning:

The Digit Span subtest from Wechsler's Adult Intelligence Scale III (WAIS-III): Verbal working memory.

Claeson-Dahl Inventory of Learning and Memory (CD): Verbal retention. The Rey Complex Figure Test (RCFT): Visuospatial retention. The Wisconsin Card Sorting Test (WCST): Cognitive flexibility. The Trail-Making Test (TMT): Sustained attention.

The presence of insomnia is examined with the Bergen Insomnia Scale (BIS) , and insomnia severity with the Insomnia Severity Index (ISI). Present pain level at the time of the neuropsychological assessment is quantified using the Visual Analogue Scale (VAS). Pain medication is transformed to the morphine equivalent daily dose (MEDD). Anxiety and depression are assessed with the Hospital Anxiety and Depression Scale.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 22
• Est. completion date: June 1, 2012
• Est. primary completion date: May 1, 2012
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• Attending tertiary chronic pain management

Exclusion Criteria:

Related Conditions & MeSH terms

• Chronic Pain
• Insomnia
• Sleep Initiation and Maintenance Disorders

Intervention

Diagnostic Test:
• Neuropsychological assessment
Assessment with a neuropsychological test battery examining different aspects of memory and executive functioning

Locations

Country	Name	City	State
Sweden	Uppsala University	Uppsala

Sponsors (1)

Lead Sponsor	Collaborator
Uppsala University

Country where clinical trial is conducted

Sweden, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Memory impairment	Composite score comprising verbal working memory, verbal retention, and visuospatial retention.	1 day
Secondary	Executive functioning impairment	Composite score comprising cognitive flexibility and sustained attention.	1 day