Chronic Pain Clinical Trial
Official title:
A Pilot fMRI Study of Fibromyalgia: Tai Chi Intervention
This exploratory study proposal is the first pilot brain imaging study to determine if Tai Chi can modulate brain resting state functional connectivity (rsFC) and brain morphometry among fibromyalgia (FM) patients and healthy controls.
Twenty-four FM patients and 24 age matched healthy control will be recruited. All FM
patients will undergo Tai Chi intervention twice weekly for 12 weeks of practice. fMRI
resting state and brain structure data will be collected before and after treatment. For the
healthy control group, the fMRI and structure data will only be collected once,
contemporaneous with the 12 week scan for the fibromyalgia patients.
The primary outcome will be rsFC of rostral anterior cingulate cortex (rACC), a key region
in descending pain modulatory system (DPMS). The secondary outcome include change of the
cortical thickness changes, fibromyalgia symptom severity, widespread pain index,
depression, stress/anxiety, sleep quality, and quality of life. Covariates include age,
gender, body mass index, disease duration, depression, and comorbidities. Clinical outcome
measurements will be collected at baseline and after 12 weeks of intervention for the
fibromyalgia cohort and at a single visit for the healthy controls. The Tai Chi classes will
be taught at Tufts Medical Center and the fMRI scans will be performed at Massachusetts
General Hospital Martinos Center.
The project will advance science in the field of mind-body medicine for chronic pain
management, both mechanistically and clinically.
;
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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