Chronic Pain Clinical Trial
Official title:
Investigating Pain Processing in the Brain, Brainstem, and Spinal Cord With fMRI
Verified date | December 2015 |
Source | Northwestern University |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Institutional Review Board |
Study type | Observational |
New advances in medical imaging have allowed for the measurement of brain activity related to chronic pain. In addition to the brain, the investigators aim to use functional magnetic resonance imaging to investigate pain processing in the brainstem and spinal cord in healthy subjects and chronic neck pain patients. The information gained from this study will increase the investigators understanding of how chronic pain is encoded in the nervous system and assist in developing more effective treatment strategies.
Status | Completed |
Enrollment | 13 |
Est. completion date | December 2015 |
Est. primary completion date | December 2015 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 21 Years to 60 Years |
Eligibility |
Healthy subjects must meet all of the following inclusion criteria to participate in this
study: 1. Age between 21 and 60 years old 2. Right-handed; not currently experiencing significant pain 3. No history of a chronic pain syndrome such as fibromyalgia, complex regional pain syndrome, chronic low back pain, etc. Chronic neck pain patients must meet all of the following inclusion criteria to participate in this study: 1. Age between 21 and 60 years old 2. Right handed; neck pain > 3 months duration; moderate neck pain score > 30 on VAS (0-100) 3) No history of a chronic pain syndrome (fibromyalgia, complex regional pain syndrome, chronic low back pain, etc.) other than chronic neck pain and its associated symptoms. Participants meeting any of the following exclusion criteria at baseline will be excluded from study participation: 1. Non-English speaking 2. Signs of upper extremity sensation loss; history of significant cerebrovascular disease including (but not limited to) epilepsy, stroke, tumor, multiple sclerosis, meningitis 3. History of major head trauma with sustained loss of consciousness; history of neurosurgery, ENT surgery, spine surgery, or cardiac surgery 4. History of cardiac pacemaker or neurostimulator implantation 5. History of significant medical illness including cardiovascular disease, uncontrolled diabetes, uncontrolled hypertension, cancer, chronic obstructive pulmonary disease, severe asthma requiring hospitalization for treatment, renal insufficiency requiring dialysis, etc. 6. History of alcoholism or consistent drug use; current infection or fever; pregnancy (or possible pregnancy) 7. History of metal working or injury with shrapnel or metal slivers 8. Claustrophobia 9. Piercings that are unable to be removed and tattoos older than 30 years |
Observational Model: Case Control, Time Perspective: Cross-Sectional
Country | Name | City | State |
---|---|---|---|
United States | Center for Translational Imaging, Northwestern University | Chicago | Illinois |
Lead Sponsor | Collaborator |
---|---|
Northwestern University | National Center for Complementary and Integrative Health (NCCIH) |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Functional magnetic resonance imaging | Use functional magnetic resonance imaging to characterize brain, brainstem, and spinal cord pain processing in healthy subjects (thermal pain) and chronic neck pain patients (thermal pain and spontaneous clinical pain). | 1.5-2.25 hours | No |
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