Chronic Pain Clinical Trial
Official title:
Predictive Markers of the Effects of Opioid Therapy in Opioid naïve Patients With Chronic Pain: an International, Multi-centre, Observational Cohort Study (ABILITY)
The overall goal of the ABILITY study is to help improve pain diagnostics and treatment by
developing an implementable clinical computerised decision support system based on
individual patient characteristics.
The investigators hypothesize that successful pain control with opioids can be predicted
before treatment initiation with advanced data analyses of data originating from
pre-treatment EEG, QST and pain-related catastrophic thinking.
The primary objective of this study is the identification of markers that can be used to
individualize treatment recommendations, i.e. to reliably predict the response of pain to
opioids.
Markers are selected among the most promising data and machine-learning methods are used for
the prediction. This includes determining the associations between a battery of selected
pre-treatment clinical predictive markers and the analgesic effect of opioid treatment in
opioid naïve chronic pain patients, including indication and responder identification.
The key secondary objectives are as follows: to investigate pre-treatment clinical
predictive markers as predictors of opioid treatment efficacy and effectiveness in terms of
the following:
- Pain intensity and unpleasantness
- Use of rescue analgesics
- Physical functioning
- Global improvement and satisfaction with treatment
n/a
Observational Model: Cohort, Time Perspective: Prospective
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