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NCT02289261 Clinical Trial

A Comparison of Morphine and Morphine Plus Dexmedetomidine in Chronic Cancer Pain

Chronic Pain Clinical Trial

Official title:
A Comparison of Morphine and Morphine Plus Dexmedetomidine in Chronic Cancer Pain

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02289261
Other study ID # MDICP01
Secondary ID
Status Completed
Phase Phase 4
First received
Last updated
Start date November 2014
Est. completion date February 2015

Study information
Verified date June 2018
Source Cukurova University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The purpose of this study is to determine whether dexmedetomidine added to morphine is effective in the treatment of chronic cancer pain.

Description:

We conduct the study in Cukurova University Faculty of Medicine Research Hospital after obtaining ethics committee approval and patient's informed consent. Patients with cancer pain are allocated into two group to receive Patient Controlled Analgesia with morphine or morphine plus dexmedetomidine.

Recruitment information / eligibility
Status Completed
Enrollment 40
Est. completion date February 2015
Est. primary completion date February 2015
Accepts healthy volunteers No
Gender All
Age group 20 Years to 80 Years
Eligibility Inclusion Criteria:

- patients with chronic cancer pain

- between 20-80 years old age

Exclusion Criteria:

- the presence of severe systemic disease(cardiac, pulmonary, hepatic or renal)

- psychiatric or neurologic disease

- unable to communicate verbally

- nausea and vomiting

- patient's refusal

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Morphine
Morphine, 0.02 mg/kg PCA bolus dose with 10 minutes lock-out interval
• Morphine plus dexmedetomidine
Morphine 0.02 mg/kg plus dexmedetomidine 0.1 microgram/kg PCA bolus dose with 10 minutes lock-out interval

Locations
Country Name City State
Turkey Cukurova University Faculty of Medicine Research Hospital Adana

Sponsors (1)
Lead Sponsor Collaborator
Cukurova University

Country where clinical trial is conducted

Turkey, 

References & Publications (2)

Blaudszun G, Lysakowski C, Elia N, Tramèr MR. Effect of perioperative systemic a2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials. Anesthesiology. 2012 Jun;116(6):1312-22. doi: 10.1097/ALN.0b013e31825681cb. Review. — View Citation

Lin TF, Yeh YC, Lin FS, Wang YP, Lin CJ, Sun WZ, Fan SZ. Effect of combining dexmedetomidine and morphine for intravenous patient-controlled analgesia. Br J Anaesth. 2009 Jan;102(1):117-22. doi: 10.1093/bja/aen320. Epub 2008 Nov 5. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary Morphine consumption (mg) cumulative morphine consumption for 24 hours 24 hours
Secondary Pain score visual analog scale to assess pain degree 24 hours
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