Chronic Pain Clinical Trial
Official title:
Impact of Dexamethasone on the Post Operative Inflammatory Response and on the Occurrence of Post Thoracotomy Pain Syndrome
NCT number | NCT02112864 |
Other study ID # | dexaPTPS |
Secondary ID | |
Status | Recruiting |
Phase | N/A |
First received | |
Last updated | |
Start date | May 2014 |
Est. completion date | July 2025 |
Post thoracotomy pain syndrome still affects 50% of patients after a thoracic surgery. Pathogenesis is unclear but there is growing evidence that neuro inflammation may play a significant role. Dexamethasone is a very potent anti-inflammatory drug. The hypothesis of this study is that dexamethasone, given pre operatively, would help reduce the incidence of post thoracotomy pain syndrome 3 months after surgery, by reducing the inflammatory response, in patients undergoing elective thoracic surgery that includes thoracic epidural analgesia.
Status | Recruiting |
Enrollment | 60 |
Est. completion date | July 2025 |
Est. primary completion date | December 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 75 Years |
Eligibility | Inclusion Criteria: - elective thoracic surgery using a thoracotomy incision and thoracic epidural analgesia - ASA I-III - age 18-75 yo Exclusion Criteria: - contra-indication to thoracic epidural analgesia - patient refusal - patients already taking cortisone or dexamethasone - patients on chronic opioid medication |
Country | Name | City | State |
---|---|---|---|
Canada | Maisonneuve-Rosemont Hospital | Montreal | Quebec |
Lead Sponsor | Collaborator |
---|---|
Maisonneuve-Rosemont Hospital |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | cytokine elevation | 24 h after surgery | ||
Secondary | incidence of post thoracotomy pain syndrome | 3 months after surgery | ||
Secondary | incidence of post thoracotomy pain syndrome | 6 months after surgery | ||
Secondary | incisional and shoulder pain | acute post operative period | ||
Secondary | Brief pain inventory questionnaire | three months after surgery | ||
Secondary | Brief pain inventory questionnaire | 6 months after surgery | ||
Secondary | Leeds Assessment of Neuropathic Signs and Symptoms questionnaire | three and six months after surgery | ||
Secondary | cytokine elevation | 1h after surgery | ||
Secondary | cytokine elevation | 48 h after surgery |
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