Chronic Pain Clinical Trial
Official title:
Effect of Paracetamol on the Status in Glutathione for the Aged Person
Paracetamol is one of the most widely used analgesics in the world especially for chronic
pain in the elderly. The metabolism of paracetamol occurs in the liver and involves the use
of glutamyl-cysteinyl-glycine (Glutathione (GSH)). Medications such as paracetamol, may
reduce the reserves of GSH because it is used for detoxification and elimination. It is well
known that the concentration of GSH decrease after administration of paracetamol in humans
and animals.
Aging is associated with decreased concentration of GSH in cells and tissues. In the
elderly, a decrease of GSH concentration in plasma or red blood cells is associated with
decreased physical and mental health.
We wish here to determine, in subjects aged over 70 years, the blood concentration of
glutathione (GSH) and urinary loss of cysteine in the detoxification of paracetamol, when
taking paracetamol treatment repeated.
Paracetamol is one of the most widely used analgesics in the world especially for chronic
pain in the elderly. The metabolism of paracetamol occurs in the liver and involves the use
of glutamyl-cysteinyl-glycine (glutathione (GSH)). Medications such as paracetamol, may
reduce the reserves of GSH because it is used for detoxification and elimination. It is well
known that the concentration of GSH decrease after administration of paracetamol in humans
and animals.
Aging is associated with decreased concentration of GSH in cells and tissues. In the
elderly, a decrease of GSH concentration in plasma or red blood cells is associated with
decreased physical and mental health.
We wish here to determine, in subjects aged over 70 years, the blood concentration of
glutathione (GSH) and urinary loss of cysteine in the detoxification of paracetamol, when
taking paracetamol treatment repeated.
;
Allocation: Non-Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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