Effects of Transcranial Magnetic Stimulation (TMS) and Stimulus Controllability on Pain Perception

Chronic Pain Clinical Trial

Official title:

Effects of TMS and Stimulus Controllability on Pain Perception

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01030133
• Other study ID #: Borckardt_19079
• Status: Completed
• Phase: N/A
• Start date: October 2009
• Est. completion date: February 2010

Study information

• Verified date: August 2018
• Source: Medical University of South Carolina
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Although transcranial magnetic stimulation (TMS) is now considered a minimal risk intervention, is approved for the treatment of depression, and is widely used around the world, little is known about mechanisms of action of prefrontal rTMS for depression or pain. There is some evidence that the prefrontal cortex is involved in perception of control and may moderate the effects of perceived controllability on emotional reactivity to painful stimuli. The present study aims to investigate the effects of prefrontal rTMS and perceived controllability on pain perception in healthy adults.

Description:

Transcranial magnetic stimulation (TMS) is a minimally invasive brain stimulation technology that can focally stimulate the brain of an awake individual.1,2 A localized pulsed magnetic field transmitted through a figure-8 coil (lasting only microseconds) is able to focally stimulate the cortex by depolarizing superficial neurons3,4 which induces electrical currents in the brain.5 If TMS pulses are delivered repetitively and rhythmically, the process is called repetitive TMS (rTMS).

rTMS over the prefrontal cortex has been shown to produce temporary analgesic effects in healthy adults using laboratory pain methods and in patients with chronic pain of various etiologies. However, little is known about mechanisms of action.

Evidence from functional MRI studies suggests that participants' perceived controllability over pain stimuli is associated with decreased pain experience and decreased activation of cortical and subcortical areas involved with pain perception.6 Perceived controllability may involved prefrontal cortical circuits and may be involved in inhibition of limbic system responses to painful stimuli.

To date, no studies have investigated the interaction between prefrontal TMS and perceived controllability on pain perception in healthy adults. Building on extensive pilot work and experience in the area of laboratory pain assessment and TMS in the Brain Stimulation Laboratory at MUSC, the investigators propose to investigate the effects of perceived controllability and prefrontal TMS on pain perception in healthy adults. This study may help determine whether TMS can be used to stimulate a cortical area thought to be involved in perceived controllability, thus enhancing one's sense of controllability and thereby substantially reduce pain intensity and unpleasantness.

Although transcranial magnetic stimulation (TMS) is now considered a minimal risk intervention, is approved for the treatment of depression, and is widely used around the world, little is known about mechanisms of action of prefrontal rTMS for depression or pain. There is some evidence that the prefrontal cortex is involved in perception of control and may moderate the effects of perceived controllability on emotional reactivity to painful stimuli. The present study aims to investigate the effects of prefrontal rTMS and perceived controllability on pain perception in healthy adults.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 28
• Est. completion date: February 2010
• Est. primary completion date: January 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• 18-75 years of age

Exclusion Criteria:

• history of seizures or epilepsy

• family history of seizures

• history of chronic pain conditions

• current depression

• anxiety disorders

• taking any medications shown to lower seizure threshold

• metal implants above the waist

• pregnant

• brain tumors or lesions

• pacemaker

Related Conditions & MeSH terms

• Chronic Pain

Intervention

Device:
• Operator Role Real TMS
In two of the four visits, the participant will be assigned to the operator condition receiving Real TMS. The participant will be assigned a partner and both participants will participate in a numeric-combination-guessing task. Performance on this task will be directly related to the painfulness of a series of thermal stimuli that participants receive. The "operator's" performance will control the painfulness delivered to both participants. Each participant will play each role twice.
• Receiver Role Real TMS
In two of the four visits, the participant will be assigned to the receiver condition receiving Real TMS. The participant will be assigned a partner and both participants will participate in a numeric-combination-guessing task. Performance on this task will be directly related to the painfulness of a series of thermal stimuli that participants receive. The "receiver's" performance on the task will be unrelated to his/her stimulus painfulness. Each participant will play each role twice.
• Operator Role Sham TMS
In two of the four visits, the participant will be assigned to the operator condition receiving Sham TMS. The participant will be assigned a partner and both participants will participate in a numeric-combination-guessing task. Performance on this task will be directly related to the painfulness of a series of thermal stimuli that participants receive. The "operator's" performance will control the painfulness delivered to both participants. Each participant will play each role twice.
• Receiver Role Sham TMS
In two of the four visits, the participant will be assigned to the receiver condition receiving Sham TMS. The participant will be assigned a partner and both participants will participate in a numeric-combination-guessing task. Performance on this task will be directly related to the painfulness of a series of thermal stimuli that participants receive. The "receiver's" performance on the task will be unrelated to his/her stimulus painfulness. Each participant will play each role twice.
• All Participants Operator Role
All participants in Operator Role (Receiving real or sham TMS)

Locations

Country	Name	City	State
United States	Brain Stimulation Laboratory, Institute of Psychiatry	Charleston	South Carolina

Sponsors (1)

Lead Sponsor	Collaborator
Medical University of South Carolina

Country where clinical trial is conducted

United States, 

References & Publications (1)

Borckardt JJ, Reeves ST, Frohman H, Madan A, Jensen MP, Patterson D, Barth K, Smith AR, Gracely R, George MS. Fast left prefrontal rTMS acutely suppresses analgesic effects of perceived controllability on the emotional component of pain experience. Pain. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Pain Unpleasantness During Perceived Control Condition	The perceived control condtion of the pain task consisted of 30 trials of 1 to 4 seconds of thermal stimulus accompanied by 5 seconds of real or sham TMS). The entire pain task (perceived control condition and no control condition) consisted of 60 trials. Participants in the operator role group rated the unpleasantness of each thermal stimulus on a computerized visual analog scale (VAS). Unpleasantness ratings are on a scale of 0 to 100. 0=not unpleasant. 100=extremely unpleasant. The ratings were averaged over all trials for the perceived control condition for the Real TMS and Sham TMS group. The results below, report the mean unpleasantness rating for both groups during the perceived control condition.	30 trials of 1 to 4 seconds of thermal stimulus accompanied by 5 seconds of real or sham TMS
Primary	Pain Intensity During Perceived Control Condition	The perceived control condtion of the pain task consisted of 30 trials of 1 to 4 seconds of thermal stimulus accompanied by 5 seconds of real or sham TMS). The entire pain task (perceived control condition and no control condition) consisted of 60 trials.), participants in the operator role group rated the pain intensity of each thermal stimulus on a computerized visual analog scale (VAS). Pain intensity ratings are on a scale of 0 to 100. 0=not painful. 100=extremely painful. The ratings were averaged over all trials for the perceived control condition for the Real TMS and Sham TMS group. The results below, report the mean pain intensity rating for both groups during the perceived control condition.	30 trials of 1 to 4 seconds of thermal stimulus accompanied by 5 seconds of real or sham TMS
Secondary	Number of Participants That Correctly Guessed Their TMS Condition Assignment	After each participant completed the experiment, they guessed their TMS Condition, whether they received real or sham TMS.; Results below report the number of participants in each group that guessed their TMS condition correctly.	After Pain Control Paradigm
Secondary	Confidence Ratings of Guessing TMS Condition Assignment	After participants guessed their TMS condition; whether they received real or sham TMS, They were then asked to rate the confidence in their guess. Ratings were on a scale of 0-10 where 0=complete guess and 10=absolutely sure.; Results below include the mean confidence ratings of those that guessed the TMS condition correctly and those that guessed incorrectly.	After Pain Control Paradigm

External Links

•   Article titled Fast left prefrontal rTMS acutely suppresses analgesic effects of perceived controllability on the emotional component of pain experience